7N4L
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibody WRAIR-2125.
Summary for 7N4L
Entry DOI | 10.2210/pdb7n4l/pdb |
Descriptor | Spike protein S1, WRAIR-2125 antibody Fab heavy chain, WRAIR-2125 antibody Fab light chain (3 entities in total) |
Functional Keywords | neutralizing antibody, sars-cov-2, wrair-2125, receptor binding domain, antiviral protein, viral protein-immune system complex, viral protein/immune system |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) More |
Total number of polymer chains | 3 |
Total formula weight | 71341.34 |
Authors | Sankhala, R.S.,Joyce, M.G. (deposition date: 2021-06-04, release date: 2021-11-10, Last modification date: 2023-10-18) |
Primary citation | Dussupt, V.,Sankhala, R.S.,Mendez-Rivera, L.,Townsley, S.M.,Schmidt, F.,Wieczorek, L.,Lal, K.G.,Donofrio, G.C.,Tran, U.,Jackson, N.D.,Zaky, W.I.,Zemil, M.,Tritsch, S.R.,Chen, W.H.,Martinez, E.J.,Ahmed, A.,Choe, M.,Chang, W.C.,Hajduczki, A.,Jian, N.,Peterson, C.E.,Rees, P.A.,Rutkowska, M.,Slike, B.M.,Selverian, C.N.,Swafford, I.,Teng, I.T.,Thomas, P.V.,Zhou, T.,Smith, C.J.,Currier, J.R.,Kwong, P.D.,Rolland, M.,Davidson, E.,Doranz, B.J.,Mores, C.N.,Hatziioannou, T.,Reiley, W.W.,Bieniasz, P.D.,Paquin-Proulx, D.,Gromowski, G.D.,Polonis, V.R.,Michael, N.L.,Modjarrad, K.,Joyce, M.G.,Krebs, S.J. Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations. Nat.Immunol., 22:1503-1514, 2021 Cited by PubMed: 34716452DOI: 10.1038/s41590-021-01068-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.601 Å) |
Structure validation
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