4BEW
| SERCA bound to phosphate analogue | Descriptor: | (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, ACETATE ION, MAGNESIUM ION, ... | Authors: | Drachmann, N.D, Mattle, D, Laursen, M, Bublitz, M, Olesen, C, Moeller, J.V, Nissen, P, Morth, J.P. | Deposit date: | 2013-03-12 | Release date: | 2014-02-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Serca Bound to Phosphate Analogue To be Published
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6A69
| Cryo-EM structure of a P-type ATPase | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Neuroplastin, Plasma membrane calcium-transporting ATPase 1 | Authors: | Gong, D.S, Chi, X.M, Ren, K, Huang, G.X.Y, Zhou, G.W, Yan, N, Lei, J.L, Zhou, Q. | Deposit date: | 2018-06-27 | Release date: | 2018-09-19 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.11 Å) | Cite: | Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin. Nat Commun, 9, 2018
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8WA5
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7QTV
| Beryllium fluoride form of the Na+,K+-ATPase (E2-BeFx) | Descriptor: | 1-O-decanoyl-beta-D-tagatofuranosyl beta-D-allopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Fruergaard, M.U, Dach, I, Andersen, J.L, Ozol, M, Shahsavar, A, Quistgaard, E.M, Poulsen, H, Fedosova, N.U, Nissen, P. | Deposit date: | 2022-01-16 | Release date: | 2022-11-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (4.05 Å) | Cite: | The Na + ,K + -ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state. J.Biol.Chem., 298, 2022
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6YAA
| Structure of the (SR) Ca2+-ATPase bound to the inhibitor compound CAD204520 and TNP-ATP | Descriptor: | 4-[2-[(2~{R})-2-[3-propyl-6-(trifluoromethyloxy)-1~{H}-indol-2-yl]piperidin-1-yl]ethyl]morpholine, POTASSIUM ION, SPIRO(2,4,6-TRINITROBENZENE[1,2A]-2O',3O'-METHYLENE-ADENINE-TRIPHOSPHATE, ... | Authors: | Heit, S, Marchesini, M, Gherli, A, Montanaro, A, Patrizi, L, Sorrentino, C, Pagliaro, L, Rompietti, C, Kitara, S, Olesen, C.E, Moller, J.V, Savi, M, Bocchi, L, Vilella, R, Rizzi, F, Baglione, M, Rastelli, G, Loiacona, C, La Starza, R, Mecucci, C, Stegmair, K, Aversa, F, Stilli, D, Lund Winther, A.M, Sportoletti, P, Dalby-Brown, W, Roti, G, Bublitz, M. | Deposit date: | 2020-03-11 | Release date: | 2020-05-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia. Cell Chem Biol, 27, 2020
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6RB2
| Structure of the (SR)Ca2+-ATPase mutant E340A in the Ca2-E1-CaAMPPCP form | Descriptor: | CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, POTASSIUM ION, ... | Authors: | Clausen, J.D, Montigny, C, Lenoir, G, Arnou, B, Jaxel, C, Moller, J.V, Nissen, P, Andersen, J.P, Le Maire, M, Bublitz, M. | Deposit date: | 2019-04-09 | Release date: | 2020-05-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.20001125 Å) | Cite: | The SERCA residue Glu340 mediates interdomain communication that guides Ca 2+ transport. Proc.Natl.Acad.Sci.USA, 117, 2020
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5MPM
| SERCA2a from pig heart | Descriptor: | (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Drachmann, N.D, Sitsel, A, Andersen, J.L, Nissen, P, Olesen, C. | Deposit date: | 2016-12-16 | Release date: | 2018-01-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structures of the heart specific SERCA2a Ca2+-ATPase. Embo J., 38, 2019
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2O9J
| Crystal structure of calcium atpase with bound magnesium fluoride and cyclopiazonic acid | Descriptor: | (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, MAGNESIUM ION, SODIUM ION, ... | Authors: | Young, H.S, Moncoq, K.A. | Deposit date: | 2006-12-13 | Release date: | 2007-02-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The molecular basis for cyclopiazonic Acid inhibition of the sarcoplasmic reticulum calcium pump. J.Biol.Chem., 282, 2007
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7YZR
| 50 mM Rb+ soak of beryllium fluoride inhibited Na+,K+-ATPase, E2-BeFx (rigid body model) | Descriptor: | BERYLLIUM TRIFLUORIDE ION, FXYD domain-containing ion transport regulator, MAGNESIUM ION, ... | Authors: | Fruergaard, M.U, Dach, I, Andersen, J.L, Ozol, M, Shasavar, A, Quistgaard, E.M, Poulsen, H, Fedosova, N.U, Nissen, P. | Deposit date: | 2022-02-21 | Release date: | 2022-11-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (6.92 Å) | Cite: | The Na + ,K + -ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state. J.Biol.Chem., 298, 2022
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7Z04
| 10 mM Rb+ soak of beryllium fluoride inhibited Na+,K+-ATPase, E2-BeFx (rigid body model) | Descriptor: | BERYLLIUM TRIFLUORIDE ION, FXYD domain-containing ion transport regulator, MAGNESIUM ION, ... | Authors: | Fruergaard, M.U, Dach, I, Andersen, J.L, Ozol, M, Shasavar, A, Quistgaard, E.M, Poulsen, H, Fedosova, N.U, Nissen, P. | Deposit date: | 2022-02-22 | Release date: | 2022-11-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (7.5 Å) | Cite: | The Na + ,K + -ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state. J.Biol.Chem., 298, 2022
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1IWO
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2OA0
| Crystal structure of Calcium ATPase with bound ADP and cyclopiazonic acid | Descriptor: | (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Young, H.S, Moncoq, K.A. | Deposit date: | 2006-12-14 | Release date: | 2007-02-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | The molecular basis for cyclopiazonic Acid inhibition of the sarcoplasmic reticulum calcium pump. J.Biol.Chem., 282, 2007
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5NCQ
| Structure of the (SR) Ca2+-ATPase bound to a Tetrahydrocarbazole and TNP-ATP | Descriptor: | (1~{S})-~{N}-[(4-bromophenyl)methyl]-7-(trifluoromethyloxy)-2,3,4,9-tetrahydro-1~{H}-carbazol-1-amine, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, POTASSIUM ION, ... | Authors: | Bublitz, M, Kjellerup, L, O'Hanlon Cohrt, K, Gordon, S, Mortensen, A.L, Clausen, J.D, Pallin, D, Hansen, J.B, Brown, W.D, Fuglsang, A, Winther, A.-M.L. | Deposit date: | 2017-03-06 | Release date: | 2018-01-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity. PLoS ONE, 13, 2018
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6HXB
| SERCA2a from pig heart | Descriptor: | CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, POTASSIUM ION, ... | Authors: | Sitsel, A, Andersen, J.L, Nissen, P, Olesen, C. | Deposit date: | 2018-10-16 | Release date: | 2019-02-27 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Structures of the heart specific SERCA2a Ca 2+ -ATPase. Embo J., 38, 2019
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6HEF
| Room temperature structure of the (SR)Ca2+-ATPase Ca2-E1-CaAMPPCP form | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Hjorth-Jensen, S, Sorensen, T.L.M, Oksanen, E, Andersen, J.L, Olesen, C, Moller, J.V, Nissen, P. | Deposit date: | 2018-08-20 | Release date: | 2018-08-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.538 Å) | Cite: | Membrane-protein crystals for neutron diffraction. Acta Crystallogr D Struct Biol, 74, 2018
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1KJU
| Ca2+-ATPase in the E2 State | Descriptor: | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1a | Authors: | Xu, C, Rice, W.J, He, W, Stokes, D.L. | Deposit date: | 2001-12-05 | Release date: | 2001-12-19 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (6 Å) | Cite: | A structural model for the catalytic cycle of Ca(2+)-ATPase. J.Mol.Biol., 316, 2002
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4UU1
| CRYSTAL STRUCTURE OF (SR) CALCIUM-ATPASE E2(TG) IN THE PRESENCE OF DOPC | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Drachmann, N.D, Olesen, C, Moeller, J.V, Guo, Z, Nissen, P, Bublitz, M. | Deposit date: | 2014-07-24 | Release date: | 2014-10-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Comparing Crystal Structures of Ca(2+) -ATPase in the Presence of Different Lipids. FEBS J., 281, 2014
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4NAB
| Structure of the (SR)Ca2+-ATPase mutant E309Q in the Ca2-E1-MgAMPPCP form | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, POTASSIUM ION, ... | Authors: | Bublitz, M, Clausen, J.D, Arnou, B, Montigny, C, Jaxel, C, Nissen, P, Moller, J.V, Andersen, J.P, le Maire, M. | Deposit date: | 2013-10-22 | Release date: | 2013-12-18 | Last modified: | 2017-08-09 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | SERCA mutant E309Q binds two Ca(2+) ions but adopts a catalytically incompetent conformation. Embo J., 32, 2013
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4XOU
| Crystal structure of the SR Ca2+-ATPase in the Ca2-E1-MgAMPPCP form determined by serial femtosecond crystallography using an X-ray free-electron laser. | Descriptor: | CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, POTASSIUM ION, ... | Authors: | Bublitz, M, Nass, K, Drachmann, N.D, Markvardsen, A.J, Gutmann, M.J, Barends, T.R.M, Mattle, D, Shoeman, R.L, Doak, R.B, Boutet, S, Messerschmidt, M, Seibert, M.M, Williams, G.J, Foucar, L, Reinhard, L, Sitsel, O, Gregersen, J.L, Clausen, J.D, Boesen, T, Gotfryd, K, Wang, K.-T, Olesen, C, Moller, J.V, Nissen, P, Schlichting, I. | Deposit date: | 2015-01-16 | Release date: | 2015-06-10 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural studies of P-type ATPase-ligand complexes using an X-ray free-electron laser. Iucrj, 2, 2015
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1VFP
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3IXZ
| Pig gastric H+/K+-ATPase complexed with aluminium fluoride | Descriptor: | Potassium-transporting ATPase alpha, Potassium-transporting ATPase subunit beta | Authors: | Abe, K, Tani, K, Nishizawa, T, Fujiyoshi, Y. | Deposit date: | 2009-03-09 | Release date: | 2009-06-23 | Last modified: | 2024-02-21 | Method: | ELECTRON CRYSTALLOGRAPHY (6.5 Å) | Cite: | Inter-subunit interaction of gastric H+,K+-ATPase prevents reverse reaction of the transport cycle Embo J., 28, 2009
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4XE5
| Crystal structure of the Na,K-ATPase from bovine | Descriptor: | CHOLESTEROL, MAGNESIUM ION, OUABAIN, ... | Authors: | Gregersen, J.L, Mattle, D, Fedosova, N.U, Nissen, P, Reinhard, L. | Deposit date: | 2014-12-22 | Release date: | 2016-03-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.901 Å) | Cite: | Isolation, crystallization and crystal structure determination of bovine kidney Na(+),K(+)-ATPase. Acta Crystallogr.,Sect.F, 72, 2016
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4UX2
| Cryo-EM structure of antagonist-bound E2P gastric H,K-ATPase (SCH.E2. MgF) | Descriptor: | POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 1, POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA | Authors: | Abe, K, Tani, K, Fujiyoshi, Y. | Deposit date: | 2014-08-18 | Release date: | 2014-09-17 | Last modified: | 2014-11-12 | Method: | ELECTRON CRYSTALLOGRAPHY (7 Å) | Cite: | Systematic Comparison of Molecular Conformations of H+,K+-ATPase Reveals an Important Contribution of the A-M2 Linker for the Luminal Gating. J.Biol.Chem., 289, 2014
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4UU0
| CRYSTAL STRUCTURE OF (SR) CALCIUM-ATPASE E2(TG) IN THE PRESENCE OF 14:1 PC | Descriptor: | GLYCEROL, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | Authors: | Drachmann, N.D, Olesen, C, Moeller, J.V, Guo, Z, Nissen, P, Bublitz, M. | Deposit date: | 2014-07-24 | Release date: | 2014-10-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Comparing Crystal Structures of Ca(2+) -ATPase in the Presence of Different Lipids. FEBS J., 281, 2014
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4UX1
| Cryo-EM structure of antagonist-bound E2P gastric H,K-ATPase (SCH.E2. AlF) | Descriptor: | POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 1, POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA | Authors: | Abe, K, Tani, K, Fujiyoshi, Y. | Deposit date: | 2014-08-18 | Release date: | 2014-09-17 | Last modified: | 2014-11-12 | Method: | ELECTRON CRYSTALLOGRAPHY (8 Å) | Cite: | Systematic Comparison of Molecular Conformations of H+,K+-ATPase Reveals an Important Contribution of the A-M2 Linker for the Luminal Gating. J.Biol.Chem., 289, 2014
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