PDB: 287 resultsInfo pagesStatus searchChemie searchBIRD

---

1ZYR	Structure of Thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic streptolydigin Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase omega chain, ... Authors: Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E. Deposit date: 2005-06-10 Release date: 2005-09-13 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (3 Å) Cite: Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation. Cell(Cambridge,Mass.), 122, 2005
5XJ0	T. thermophilus RNA polymerase holoenzyme bound with gp39 and gp76 Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Ooi, W.Y, Murayama, Y, Mekler, V, Minakhin, L, Severinov, K, Yokoyama, S, Sekine, S. Deposit date: 2017-04-28 Release date: 2017-12-20 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (4.004 Å) Cite: A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation Nucleic Acids Res., 46, 2018
4MEY	Crystal structure of Escherichia coli RNA polymerase holoenzyme Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Feng, Y, Zhang, Y, Arnold, E, Ebright, R.H. Deposit date: 2013-08-27 Release date: 2014-05-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.948 Å) Cite: Transcription inhibition by the depsipeptide antibiotic salinamide A. Elife, 3, 2014
8AD1	RNA polymerase at U-rich pause bound to RNA putL triple mutant - pause prone, closed clamp state Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Dey, S, Weixlbaumer, A. Deposit date: 2022-07-07 Release date: 2022-10-19 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structural insights into RNA-mediated transcription regulation in bacteria. Mol.Cell, 82, 2022
7P5X	Mycobacterial RNAP with transcriptional activator PafBC Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Mueller, A.U, Kummer, E, Schilling, C.M, Ban, N, Weber-Ban, E. Deposit date: 2021-07-15 Release date: 2021-12-22 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Transcriptional control of mycobacterial DNA damage response by sigma adaptation. Sci Adv, 7, 2021
1L9Z	Thermus aquaticus RNA Polymerase Holoenzyme/Fork-Junction Promoter DNA Complex at 6.5 A Resolution Descriptor: MAGNESIUM ION, RNA POLYMERASE, ALPHA SUBUNIT, ... Authors: Murakami, K.S, Masuda, S, Campbell, E.A, Muzzin, O, Darst, S.A. Deposit date: 2002-03-27 Release date: 2002-05-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (6.5 Å) Cite: Structural basis of transcription initiation: an RNA polymerase holoenzyme-DNA complex. Science, 296, 2002
4X8K	Mycobacterium tuberculosis RbpA-SID in complex with SigmaA domain 2 Descriptor: 1,2-ETHANEDIOL, RNA polymerase sigma factor SigA, RNA polymerase-binding protein RbpA, ... Authors: Hubin, E.A, Flack, J.E, Tabib-Salazar, A, Paget, M.S, Darst, S.A, Campbell, E.A. Deposit date: 2014-12-10 Release date: 2015-06-03 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.202 Å) Cite: Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA. Proc.Natl.Acad.Sci.USA, 112, 2015
8FTD	Structure of Escherichia coli CedA in complex with transcription initiation complex Descriptor: CHAPSO, Cell division activator CedA, DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, M, Vassyliev, N, Nudler, E. Deposit date: 2023-01-11 Release date: 2024-01-10 Last modified: 2024-01-31 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: General transcription factor from Escherichia coli with a distinct mechanism of action. Nat.Struct.Mol.Biol., 31, 2024
1SMY	Structural basis for transcription regulation by alarmone ppGpp Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... Authors: Artsimovitch, I, Patlan, V, Sekine, S, Vassylyeva, M.N, Hosaka, T, Ochi, K, Yokoyama, S, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2004-03-10 Release date: 2004-05-18 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural basis for transcription regulation by alarmone ppGpp Cell(Cambridge,Mass.), 117, 2004
3LEV	HIV-1 antibody 2F5 in complex with epitope scaffold ES2 Descriptor: 2F5 ANTIBODY HEAVY CHAIN, 2F5 ANTIBODY LIGHT CHAIN, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Ofek, G, Guenaga, F.J, Schief, W.R, Skinner, J, Baker, D, Wyatt, R, Kwong, P.D. Deposit date: 2010-01-15 Release date: 2010-09-29 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Elicitation of structure-specific antibodies by epitope scaffolds. Proc.Natl.Acad.Sci.USA, 107, 2010
3LES	2F5 Epitope scaffold ES2 Descriptor: RNA polymerase sigma factor, SULFATE ION Authors: Ofek, G, Guenaga, F.J, Schief, W.R, Skinner, J, Wyatt, R, Baker, D, Kwong, P.D. Deposit date: 2010-01-15 Release date: 2010-09-29 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.77 Å) Cite: Elicitation of structure-specific antibodies by epitope scaffolds. Proc.Natl.Acad.Sci.USA, 107, 2010
1SIG	CRYSTAL STRUCTURE OF A SIGMA70 SUBUNIT FRAGMENT FROM ESCHERICHIA COLI RNA POLYMERASE Descriptor: RNA POLYMERASE PRIMARY SIGMA FACTOR Authors: Malhotra, A, Severinova, E, Darst, S.A. Deposit date: 1997-02-18 Release date: 1997-05-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase. Cell(Cambridge,Mass.), 87, 1996
8DY7	Streptomyces venezuelae RNAP transcription open promoter complex with WhiA and WhiB transcription factors Descriptor: DNA (71-MER), DNA (78-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Lilic, M, Campbell, E.A. Deposit date: 2022-08-03 Release date: 2023-03-01 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB. Proc.Natl.Acad.Sci.USA, 120, 2023
8DY9	Streptomyces venezuelae RNAP unconstrained open promoter complex with WhiA and WhiB transcription factors Descriptor: DNA (38-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Lilic, M, Campbell, E.A. Deposit date: 2022-08-03 Release date: 2023-03-01 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB. Proc.Natl.Acad.Sci.USA, 120, 2023
3DXJ	Crystal structure of thermus thermophilus rna polymerase holoenzyme in complex with the antibiotic myxopyronin Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, BACTERIAL RNA POLYMERASE BETA SUBUNIT; CHAIN C, M, ... Authors: Das, K, Arnold, E. Deposit date: 2008-07-24 Release date: 2008-10-14 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: The RNA polymerase "switch region" is a target for inhibitors. Cell(Cambridge,Mass.), 135, 2008
3EQL	Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic myxopyronin Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Vassylyev, D.G, Vassylyeva, M.N, Artsimovitch, I. Deposit date: 2008-09-30 Release date: 2008-10-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Transcription inactivation through local refolding of the RNA polymerase structure. Nature, 457, 2009
1IW7	Crystal structure of the RNA polymerase holoenzyme from Thermus thermophilus at 2.6A resolution Descriptor: LEAD (II) ION, MAGNESIUM ION, RNA polymerase alpha subunit, ... Authors: RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2002-04-22 Release date: 2002-06-26 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution NATURE, 417, 2002
4G7H	Crystal structure of Thermus thermophilus transcription initiation complex Descriptor: 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', DNA-directed RNA polymerase subunit alpha, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2012-07-20 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis of transcription initiation. Science, 338, 2012
4G7O	Crystal structure of Thermus thermophilus transcription initiation complex containing 2 nt of RNA Descriptor: 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', 5'-R(*GP*A)-3', ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2012-07-20 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.993 Å) Cite: Structural basis of transcription initiation. Science, 338, 2012
4G7Z	Crystal structure of Thermus thermophilus transcription initiation complex containing 5-BrU at template-strand position +1 Descriptor: 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*(BRU)P*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', DNA-directed RNA polymerase subunit alpha, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2012-07-20 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.815 Å) Cite: Structural basis of transcription initiation. Science, 338, 2012
3UGP	Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TATAAT) Descriptor: 5'-D(*TP*GP*TP*AP*TP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor Authors: Feklistov, A, Darst, S.A. Deposit date: 2011-11-02 Release date: 2011-12-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.697 Å) Cite: Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.), 147, 2011
3UGO	Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TACAAT) Descriptor: 5'-D(*TP*GP*TP*AP*CP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor Authors: Feklistov, A, Darst, S.A. Deposit date: 2011-11-02 Release date: 2011-12-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.096 Å) Cite: Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.), 147, 2011
1KU2	Crystal Structure of Thermus aquaticus RNA Polymerase Sigma Subunit Fragment Containing Regions 1.2 to 3.1 Descriptor: SULFATE ION, sigma factor sigA Authors: Campbell, E.A, Muzzin, O, Chlenov, M, Sun, J.L, Olson, C.A, Weinman, O, Trester-Zedlitz, M.L, Darst, S.A. Deposit date: 2002-01-21 Release date: 2002-04-03 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure of the bacterial RNA polymerase promoter specificity sigma subunit. Mol.Cell, 9, 2002
1L9U	THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME AT 4 A RESOLUTION Descriptor: MAGNESIUM ION, RNA POLYMERASE, ALPHA SUBUNIT, ... Authors: Murakami, K.S, Masuda, S, Darst, S.A. Deposit date: 2002-03-26 Release date: 2002-05-22 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (4 Å) Cite: Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 A resolution. Science, 296, 2002
3WOD	RNA polymerase-gp39 complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Tagami, S, Sekine, S, Minakhin, L, Esyunina, D, Akasaka, R, Shirouzu, M, Kulbachinskiy, A, Severinov, K, Yokoyama, S. Deposit date: 2013-12-26 Release date: 2014-03-12 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural basis for promoter specificity switching of RNA polymerase by a phage factor. Genes Dev., 28, 2014

 

123456789101112>