4IQX
| Mutant P44S P169S M296I of Foot-and-mouth disease Virus RNA-dependent RNA polymerase | Descriptor: | 3D polymerase, RNA (5'-R(*AP*UP*GP*GP*GP*CP*C)-3'), RNA (5'-R(*GP*GP*CP*CP*C)-3') | Authors: | Ferrer-Orta, C, Verdaguer, N, Agudo, R, Perez-Luque, R. | Deposit date: | 2013-01-14 | Release date: | 2013-02-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape. Plos Pathog., 6, 2010
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3VNU
| Complex structure of viral RNA polymerase I | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Elongation factor Ts, ... | Authors: | Takeshita, D, Tomita, K. | Deposit date: | 2012-01-18 | Release date: | 2012-08-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Mechanism for template-independent terminal adenylation activity of Q beta replicase Structure, 20, 2012
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8QJ7
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5UH5
| Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 3 nt of RNA | Descriptor: | DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Lin, W, Das, K, Feng, Y, Ebright, R.H. | Deposit date: | 2017-01-10 | Release date: | 2017-04-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.746 Å) | Cite: | Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
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5UHD
| Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 4nt RNA in complex with Rifampin | Descriptor: | DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Lin, W, Das, K, Feng, Y, Ebright, R.H. | Deposit date: | 2017-01-11 | Release date: | 2017-04-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (4.01 Å) | Cite: | Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
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7DKH
| Crystal structure of the Ctr9/Paf1/Cdc73/Rtf1 quaternary complex | Descriptor: | Cell division control protein 73, RNA polymerase II-associated protein 1, RNA polymerase-associated protein CTR9, ... | Authors: | Chen, F.L, Liu, B.B, Guo, L, Li, D.F, Zhou, H, Long, J.F. | Deposit date: | 2020-11-24 | Release date: | 2021-11-24 | Last modified: | 2022-01-05 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structure of the Core Module of the Yeast Paf1 Complex. J.Mol.Biol., 434, 2021
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8P7D
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8P7B
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8P7C
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8G9F
| Complete auto-inhibitory complex of Xenopus laevis DNA polymerase alpha-primase | Descriptor: | DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Mullins, E.A, Chazin, W.J, Eichman, B.F. | Deposit date: | 2023-02-21 | Release date: | 2023-04-12 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 31, 2024
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5FJ6
| Structure of the P2 polymerase inside in vitro assembled bacteriophage phi6 polymerase complex | Descriptor: | MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE | Authors: | Ilca, S, Kotecha, A, Sun, X, Poranen, M.P, Stuart, D.I, Huiskonen, J.T. | Deposit date: | 2015-10-06 | Release date: | 2015-11-04 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (7.9 Å) | Cite: | Localized Reconstruction of Subunits from Electron Cryomicroscopy Images of Macromolecular Complexes. Nat.Commun., 6, 2015
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5FJ7
| Structure of the P2 polymerase inside in vitro assembled bacteriophage phi6 polymerase complex, with P1 included | Descriptor: | MAJOR INNER PROTEIN P1, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE | Authors: | Ilca, S, Kotecha, A, Sun, X, Poranen, M.P, Stuart, D.I, Huiskonen, J.T. | Deposit date: | 2015-10-06 | Release date: | 2015-11-04 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (7.9 Å) | Cite: | Localized Reconstruction of Subunits from Electron Cryomicroscopy Images of Macromolecular Complexes. Nat.Commun., 6, 2015
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3VBB
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3T72
| PhoB(E)-Sigma70(4)-(RNAP-Betha-flap-tip-helix)-DNA Transcription Activation Sub-Complex | Descriptor: | PHO BOX DNA (STRAND 1), PHO BOX DNA (STRAND 2), Phosphate regulon transcriptional regulatory protein phoB, ... | Authors: | Blanco, A.G, Canals, A, Bernues, J, Sola, M, Coll, M. | Deposit date: | 2011-07-29 | Release date: | 2011-09-21 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (4.33 Å) | Cite: | The structure of a transcription activation subcomplex reveals how sigma (70) is recruited to PhoB promoters. Embo J., 30, 2011
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7OM9
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8V5M
| Tetramer core subcomplex (conformation 1) of Xenopus laevis DNA polymerase alpha-primase | Descriptor: | DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Mullins, E.A, Chazin, W.J, Eichman, B.F. | Deposit date: | 2023-11-30 | Release date: | 2023-12-20 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (9.22 Å) | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 31, 2024
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8V5O
| Tetramer core subcomplex (conformation 3) of Xenopus laevis DNA polymerase alpha-primase | Descriptor: | DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Mullins, E.A, Chazin, W.J, Eichman, B.F. | Deposit date: | 2023-11-30 | Release date: | 2023-12-20 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (8.99 Å) | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 31, 2024
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8V5N
| Tetramer core subcomplex (conformation 2) of Xenopus laevis DNA polymerase alpha-primase | Descriptor: | DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Mullins, E.A, Chazin, W.J, Eichman, B.F. | Deposit date: | 2023-11-30 | Release date: | 2023-12-20 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (8.56 Å) | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 31, 2024
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6XQB
| SARS-CoV-2 RdRp/RNA complex | Descriptor: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | Authors: | Liu, B, Shi, W, Yang, Y. | Deposit date: | 2020-07-09 | Release date: | 2020-07-29 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of SARS-CoV-2 RdRp/RNA complex at 3.4 Angstroms resolution To Be Published
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2Q66
| Structure of Yeast Poly(A) Polymerase with ATP and oligo(A) | Descriptor: | 1,2-ETHANEDIOL, 5'-R(P*AP*AP*AP*AP*A)-3', ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Bohm, A, Balbo, P. | Deposit date: | 2007-06-04 | Release date: | 2007-08-28 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Mechanism of poly(A) polymerase: structure of the enzyme-MgATP-RNA ternary complex and kinetic analysis. Structure, 15, 2007
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8PPV
| Intermediate conformer of Pyrococcus abyssi DNA polymerase D (PolD) bound to a primer/template substrate containing three consecutive mismatches | Descriptor: | DNA (5'-D(*P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*(GS)P*(G7P)P*(PST)P*(PST)P*(PST))-3'), DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA polymerase II small subunit, ... | Authors: | Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. | Deposit date: | 2023-07-10 | Release date: | 2023-12-20 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023
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8PPT
| Pyrococcus abyssi DNA polymerase D (PolD) in its editing mode bound to a primer/template substrate containing a mismatch | Descriptor: | DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*GP*CP*TP*TP*T)-3'), DNA polymerase II small subunit, ... | Authors: | Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. | Deposit date: | 2023-07-10 | Release date: | 2023-12-20 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023
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8PPU
| Pyrococcus abyssi DNA polymerase D (PolD) in its editing mode bound to a primer/template substrate containing three consecutive mismatches | Descriptor: | DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*(GS)P*(C7R)P*(PST)P*(PST)P*(PST))-3'), DNA polymerase II small subunit, ... | Authors: | Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. | Deposit date: | 2023-07-10 | Release date: | 2023-12-20 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023
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6DVC
| Crystal structure of Mycobacterium tuberculosis transcription initiation complex(ECF sigma factor L) containing 5nt RNA with 6nt spacer | Descriptor: | DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(P*CP*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Lin, W, Das, K, Feng, Y, Ebright, R.H. | Deposit date: | 2018-06-23 | Release date: | 2019-02-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural basis of ECF-sigma-factor-dependent transcription initiation. Nat Commun, 10, 2019
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6DVB
| Crystal structure of Mycobacterium tuberculosis transcription initiation complex(ECF sigma factor L) containing 5nt RNA with 5nt spacer | Descriptor: | DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(P*CP*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Lin, W, Das, K, Feng, Y, Ebright, R.H. | Deposit date: | 2018-06-23 | Release date: | 2019-02-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural basis of ECF-sigma-factor-dependent transcription initiation. Nat Commun, 10, 2019
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