6YF0
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![BU of 6yf0 by Molmil](/molmil-images/mine/6yf0) | FKBP12 in complex with the BMP potentiator compound 9 at 1.55 A resolution | Descriptor: | 18-HYDROXYASCOMYCIN, Peptidyl-prolyl cis-trans isomerase FKBP1A, SULFATE ION | Authors: | Kallen, J. | Deposit date: | 2020-03-25 | Release date: | 2021-03-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury. Cell Chem Biol, 28, 2021
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6MRD
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![BU of 6mrd by Molmil](/molmil-images/mine/6mrd) | ADP-bound human mitochondrial Hsp60-Hsp10 half-football complex | Descriptor: | 10 kDa heat shock protein, mitochondrial, 60 kDa heat shock protein, ... | Authors: | Gomez-Llorente, Y, Jebara, F, Patra, M, Malik, R, Nissemblat, S, Azem, A, Hirsch, J.A, Ubarretxena-Belandia, I. | Deposit date: | 2018-10-12 | Release date: | 2020-04-15 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.82 Å) | Cite: | Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin. Nat Commun, 11, 2020
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1F40
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![BU of 1f40 by Molmil](/molmil-images/mine/1f40) | SOLUTION STRUCTURE OF FKBP12 COMPLEXED WITH GPI-1046, A NEUROTROPHIC LIGAND | Descriptor: | (2S)-[3-PYRIDYL-1-PROPYL]-1-[3,3-DIMETHYL-1,2-DIOXOPENTYL]-2-PYRROLIDINECARBOXYLATE, FK506 BINDING PROTEIN (FKBP12) | Authors: | Sich, C, Improta, S, Cowley, D.J, Guenet, C, Merly, J.P, Teufel, M, Saudek, V. | Deposit date: | 2000-06-07 | Release date: | 2000-11-08 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of a neurotrophic ligand bound to FKBP12 and its effects on protein dynamics. Eur.J.Biochem., 267, 2000
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6MQ6
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![BU of 6mq6 by Molmil](/molmil-images/mine/6mq6) | Mapping the binding trajectory of a suicide inhibitor in human indoleamine 2,3-dioxygenase 1 | Descriptor: | (2R)-N-(4-chlorophenyl)-2-[cis-4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide, GLYCEROL, Indoleamine 2,3-dioxygenase 1, ... | Authors: | Pham, K.N, Yeh, S.R. | Deposit date: | 2018-10-09 | Release date: | 2018-11-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Mapping the Binding Trajectory of a Suicide Inhibitor in Human Indoleamine 2,3-Dioxygenase 1. J. Am. Chem. Soc., 140, 2018
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2YRW
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![BU of 2yrw by Molmil](/molmil-images/mine/2yrw) | Crystal structure of GAR synthetase from Geobacillus kaustophilus | Descriptor: | PHOSPHATE ION, Phosphoribosylglycinamide synthetase | Authors: | Baba, S, Kanagawa, M, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-03 | Release date: | 2007-10-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of glycinamide ribonucleotide synthetase, PurD, from thermophilic eubacteria J.Biochem., 148, 2010
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2YS6
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![BU of 2ys6 by Molmil](/molmil-images/mine/2ys6) | Crystal structure of GAR synthetase from Geobacillus kaustophilus | Descriptor: | ADENOSINE MONOPHOSPHATE, GLYCINE, Phosphoribosylglycinamide synthetase | Authors: | Baba, S, Kanagawa, M, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-03 | Release date: | 2007-10-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Crystal structures of glycinamide ribonucleotide synthetase, PurD, from thermophilic eubacteria J.Biochem., 148, 2010
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2YS7
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![BU of 2ys7 by Molmil](/molmil-images/mine/2ys7) | Crystal structure of GAR synthetase from Geobacillus kaustophilus | Descriptor: | Phosphoribosylglycinamide synthetase | Authors: | Baba, S, Kanagawa, M, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-03 | Release date: | 2007-10-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Crystal structures of glycinamide ribonucleotide synthetase, PurD, from thermophilic eubacteria J.Biochem., 148, 2010
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2Z02
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![BU of 2z02 by Molmil](/molmil-images/mine/2z02) | Crystal structure of phosphoribosylaminoimidazolesuccinocarboxamide synthase wit ATP from Methanocaldococcus jannaschii | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CITRIC ACID, Phosphoribosylaminoimidazole-succinocarboxamide synthase, ... | Authors: | Kanagawa, M, Baba, S, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-05-06 | Release date: | 2007-11-06 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Crystal structure of phosphoribosylaminoimidazolesuccinocarboxamide synthase from Methanocaldococcus jannaschii To be Published
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1KJX
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![BU of 1kjx by Molmil](/molmil-images/mine/1kjx) | IMP Complex of E. Coli Adenylosuccinate Synthetase | Descriptor: | Adenylosuccinate Synthetase, INOSINIC ACID | Authors: | Hou, Z, Wang, W, Fromm, H.J, Honzatko, R.B. | Deposit date: | 2001-12-05 | Release date: | 2002-03-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | IMP Alone Organizes the Active Site of Adenylosuccinate Synthetase from Escherichia coli. J.Biol.Chem., 277, 2002
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2AEE
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![BU of 2aee by Molmil](/molmil-images/mine/2aee) | Crystal structure of Orotate phosphoribosyltransferase from Streptococcus pyogenes | Descriptor: | CHLORIDE ION, GLYCEROL, Orotate phosphoribosyltransferase, ... | Authors: | Chang, C, Li, H, Collart, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2005-07-22 | Release date: | 2005-09-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of Orotate phosphoribosyltransferase from Streptococcus pyogenes To be Published
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2YWR
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![BU of 2ywr by Molmil](/molmil-images/mine/2ywr) | Crystal structure of GAR transformylase from Aquifex aeolicus | Descriptor: | COBALT (II) ION, MAGNESIUM ION, Phosphoribosylglycinamide formyltransferase | Authors: | Kanagawa, M, Baba, S, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-23 | Release date: | 2007-10-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Structures and reaction mechanisms of the two related enzymes, PurN and PurU. J.Biochem., 154, 2013
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2YWX
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![BU of 2ywx by Molmil](/molmil-images/mine/2ywx) | Crystal structure of phosphoribosylaminoimidazole carboxylase catalytic subunit from Methanocaldococcus jannaschii | Descriptor: | Phosphoribosylaminoimidazole carboxylase catalytic subunit | Authors: | Kanagawa, M, Baba, S, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-23 | Release date: | 2007-10-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Crystal structure of phosphoribosylaminoimidazole carboxylase catalytic subunit from Methanocaldococcus jannaschii To be Published
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2YX5
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![BU of 2yx5 by Molmil](/molmil-images/mine/2yx5) | Crystal Structure of Methanocaldococcus jannaschii PurS, One of the Subunits of Formylglycinamide Ribonucleotide Amidotransferase in the Purine Biosynthetic Pathway | Descriptor: | UPF0062 protein MJ1593 | Authors: | Kanagawa, M, Baba, S, Agari, Y, Chen, L.Q, Fu, Z.-Q, Chrzas, J, Wang, B.C, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-24 | Release date: | 2007-10-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of Methanocaldococcus jannaschii PurS, One of the Subunits of Formylglycinamide Ribonucleotide Amidotransferase in the Purine Biosynthetic Pathway To be Published
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2AD5
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![BU of 2ad5 by Molmil](/molmil-images/mine/2ad5) | Mechanisms of feedback regulation and drug resistance of CTP synthetases: structure of the E. coli CTPS/CTP complex at 2.8-Angstrom resolution. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CTP synthase, CYTIDINE-5'-TRIPHOSPHATE, ... | Authors: | Endrizzi, J.A, Kim, H, Anderson, P.M, Baldwin, E.P. | Deposit date: | 2005-07-19 | Release date: | 2005-11-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Mechanisms of Product Feedback Regulation and Drug Resistance in Cytidine Triphosphate Synthetases from the Structure of a CTP-Inhibited Complex(,). Biochemistry, 44, 2005
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1MC4
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![BU of 1mc4 by Molmil](/molmil-images/mine/1mc4) | |
1MEZ
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![BU of 1mez by Molmil](/molmil-images/mine/1mez) | Structure of the Recombinant Mouse-Muscle Adenylosuccinate Synthetase Complexed with SAMP, GDP, SO4(2-), and Mg(2+) | Descriptor: | 2-[9-(3,4-DIHYDROXY-5-PHOSPHONOOXYMETHYL-TETRAHYDRO-FURAN-2-YL)-9H-PURIN-6-YLAMINO]-SUCCINIC ACID, Adenylosuccinate Synthetase, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Iancu, C.V, Borza, T, Fromm, H.J, Honzatko, R.B. | Deposit date: | 2002-08-09 | Release date: | 2002-10-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Feedback inhibition and product complexes of recombinant mouse muscle adenylosuccinate synthetase. J.Biol.Chem., 277, 2002
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2A1F
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![BU of 2a1f by Molmil](/molmil-images/mine/2a1f) | |
1MF0
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![BU of 1mf0 by Molmil](/molmil-images/mine/1mf0) | Structure of the Recombinant Mouse-Muscle Adenylosuccinate Synthetase Complexed with AMP, GDP, HPO4(2-), and Mg(2+) | Descriptor: | ADENOSINE MONOPHOSPHATE, Adenylosuccinate Synthetase, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Iancu, C.V, Borza, T, Fromm, H.J, Honzatko, R.B. | Deposit date: | 2002-08-09 | Release date: | 2002-10-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Feedback inhibition and product complexes of recombinant mouse muscle adenylosuccinate synthetase. J.Biol.Chem., 277, 2002
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1MF1
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![BU of 1mf1 by Molmil](/molmil-images/mine/1mf1) | Structure of the Recombinant Mouse-Muscle Adenylosuccinate Synthetase Complexed with AMP | Descriptor: | ACETATE ION, ADENOSINE MONOPHOSPHATE, Adenylosuccinate Synthetase | Authors: | Iancu, C.V, Borza, T, Fromm, H.J, Honzatko, R.B. | Deposit date: | 2002-08-09 | Release date: | 2002-10-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Feedback inhibition and product complexes of recombinant mouse muscle adenylosuccinate synthetase. J.Biol.Chem., 277, 2002
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1GRC
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![BU of 1grc by Molmil](/molmil-images/mine/1grc) | |
6O3I
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![BU of 6o3i by Molmil](/molmil-images/mine/6o3i) | Crystal Structure of Human IDO1 bound to navoximod (NLG-919) | Descriptor: | Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, trans-4-{(1R)-2-[(5S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl]-1-hydroxyethyl}cyclohexan-1-ol | Authors: | Harris, S.F, Oh, A. | Deposit date: | 2019-02-26 | Release date: | 2019-07-17 | Last modified: | 2019-08-07 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Discovery of Clinical Candidate (1R,4r)-4-((R)-2-((S)-6-Fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a Potent and Selective Inhibitor of Indoleamine 2,3-Dioxygenase 1. J.Med.Chem., 62, 2019
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2YZL
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![BU of 2yzl by Molmil](/molmil-images/mine/2yzl) | Crystal structure of phosphoribosylaminoimidazole-succinocarboxamide synthase with ADP from Methanocaldococcus jannaschii | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Phosphoribosylaminoimidazole-succinocarboxamide synthase, SULFATE ION | Authors: | Kanagawa, M, Baba, S, Fukui, K, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-05-06 | Release date: | 2007-11-06 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of phosphoribosylaminoimidazole-succinocarboxamide synthase with ADP from Methanocaldococcus jannaschii To be Published
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1FKH
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![BU of 1fkh by Molmil](/molmil-images/mine/1fkh) | DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12 | Descriptor: | 1-CYCLOHEXYL-3-PHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE CARBOXYLATE, FK506 BINDING PROTEIN | Authors: | Holt, D.A, Luengo, J.I, Yamashita, D.S, Oh, H.-J, Konialian, A.L, Yen, H.-K, Rozamus, L.W, Brandt, M, Bossard, M.J, Levy, M.A, Eggleston, D.S, Stout, T.J, Liang, J, Schultz, L.W, Clardy, J. | Deposit date: | 1993-08-05 | Release date: | 1994-01-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12. J.Am.Chem.Soc., 115, 1993
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2YWV
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![BU of 2ywv by Molmil](/molmil-images/mine/2ywv) | Crystal structure of SAICAR synthetase from Geobacillus kaustophilus | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Phosphoribosylaminoimidazole succinocarboxamide synthetase, ... | Authors: | Kanagawa, M, Baba, S, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-23 | Release date: | 2007-10-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structure of SAICAR synthetase from Geobacillus kaustophilus To be Published
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6O55
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![BU of 6o55 by Molmil](/molmil-images/mine/6o55) | |