2AD5

Mechanisms of feedback regulation and drug resistance of CTP synthetases: structure of the E. coli CTPS/CTP complex at 2.8-Angstrom resolution.

Summary for 2AD5

Entry DOI	10.2210/pdb2ad5/pdb
Related	1S1M 1VCM
Descriptor	CTP synthase, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	rossmann fold, p-loop atpase, interfacial active site, ligase
Biological source	Escherichia coli K12
Total number of polymer chains	2
Total formula weight	122763.28
Authors	Endrizzi, J.A.,Kim, H.,Anderson, P.M.,Baldwin, E.P. (deposition date: 2005-07-19, release date: 2005-11-01, Last modification date: 2023-08-23)
Primary citation	Endrizzi, J.A.,Kim, H.,Anderson, P.M.,Baldwin, E.P. Mechanisms of Product Feedback Regulation and Drug Resistance in Cytidine Triphosphate Synthetases from the Structure of a CTP-Inhibited Complex(,). Biochemistry, 44:13491-13499, 2005 Cited by PubMed: 16216072 DOI: 10.1021/bi051282o PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation