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1KV3
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BU of 1kv3 by Molmil
HUMAN TISSUE TRANSGLUTAMINASE IN GDP BOUND FORM
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase
Authors:Liu, S, Cerione, R.A, Clardy, J.
Deposit date:2002-01-24
Release date:2002-03-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity.
Proc.Natl.Acad.Sci.USA, 99, 2002
4YT6
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BU of 4yt6 by Molmil
Factor VIIa in complex with the inhibitor 4-{[(R)-[5-ethoxy-2-fluoro-3-(propan-2-yloxy)phenyl](4-phenyl-1H-imidazol-2-yl)methyl]amino}benzenecarboximidamide
Descriptor: 4-[[(R)-(5-ethoxy-2-fluoranyl-3-propan-2-yloxy-phenyl)-(4-phenyl-1H-imidazol-2-yl)methyl]amino]benzenecarboximidamide, CALCIUM ION, Coagulation factor VII (heavy chain), ...
Authors:Wei, A.
Deposit date:2015-03-17
Release date:2015-04-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
4YT7
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BU of 4yt7 by Molmil
Factor VIIa in complex with the inhibitor 2-(2-{(R)-[(4-carbamimidoylphenyl)amino][5-ethoxy-2-fluoro-3-(propan-2-yloxy)phenyl]methyl}-1H-imidazol-4-yl)benzamide
Descriptor: 2-[2-[(R)-[(4-carbamimidoylphenyl)amino]-(5-ethoxy-2-fluoranyl-3-propan-2-yloxy-phenyl)methyl]-1H-imidazol-4-yl]benzamide, CALCIUM ION, Coagulation factor VII (heavy chain), ...
Authors:Wei, A.
Deposit date:2015-03-17
Release date:2015-04-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
3OJM
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BU of 3ojm by Molmil
Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation
Descriptor: Fibroblast growth factor receptor 2, Heparin-binding growth factor 1, SULFATE ION
Authors:Beenken, A, Mohammadi, M.
Deposit date:2010-08-23
Release date:2011-08-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1.
J.Biol.Chem., 287, 2012
3OJ2
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BU of 3oj2 by Molmil
Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer syndrome mutation
Descriptor: Fibroblast growth factor receptor 2, Heparin-binding growth factor 1, SULFATE ION
Authors:Beenken, A, Mohammadi, M.
Deposit date:2010-08-20
Release date:2011-08-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1.
J.Biol.Chem., 287, 2012
3OJV
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BU of 3ojv by Molmil
Crystal Structure of FGF1 complexed with the ectodomain of FGFR1c exhibiting an ordered ligand specificity-determining betaC'-betaE loop
Descriptor: 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Basic fibroblast growth factor receptor 1, Heparin-binding growth factor 1
Authors:Beenken, A, Mohammadi, M.
Deposit date:2010-08-23
Release date:2011-12-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1.
J.Biol.Chem., 287, 2012
4NG9
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BU of 4ng9 by Molmil
Factor viia in complex with the inhibitor (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-n-(3-sulfamoylbenzyl)ethanamide
Descriptor: (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-N-(3-sulfamoylbenzyl)ethanamide, CALCIUM ION, Factor VIIa (Heavy Chain), ...
Authors:Wei, A, Anumula, R.
Deposit date:2013-11-01
Release date:2014-01-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors.
ACS Med Chem Lett, 5, 2014
5ZXE
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BU of 5zxe by Molmil
Structure of a consensus sequence derived from the FGF family
Descriptor: CHLORIDE ION, Consensus sequence based basic form of fibroblast growth factor, GLYCEROL, ...
Authors:Tripathi, S.K, Mandalaparthy, V, Ramaswamy, S, Gosavi, S.
Deposit date:2018-05-19
Release date:2019-07-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of a consensus sequence derived from the FGF family
To be published
7S7M
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BU of 7s7m by Molmil
Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66D/T98G/P131S/Q153N) with matrix metalloproteinase-3 catalytic domain (MMP-3cd)
Descriptor: CALCIUM ION, Metalloproteinase inhibitor 1, Stromelysin-1, ...
Authors:Coban, M, Raeeszadeh-Sarmazdeh, M, Sankaran, B, Hockla, A, Radisky, E.S.
Deposit date:2021-09-16
Release date:2022-03-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10.
J.Biol.Chem., 298, 2022
7S7L
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BU of 7s7l by Molmil
Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66S/E67Y/L133N/S155L) with matrix metalloproteinase-3 catalytic domain (MMP-3cd)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CALCIUM ION, ...
Authors:Coban, M, Raeeszadeh-Sarmazdeh, M, Hockla, A, Sankaran, B, Radisky, E.S.
Deposit date:2021-09-16
Release date:2022-03-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10.
J.Biol.Chem., 298, 2022
5VQP
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BU of 5vqp by Molmil
Crystal structure of human pro-TGF-beta1
Descriptor: Transforming growth factor beta-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Zhao, B, Xu, S, Dong, X, Lu, C, Springer, T.A.
Deposit date:2017-05-09
Release date:2017-11-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Prodomain-growth factor swapping in the structure of pro-TGF-beta 1.
J. Biol. Chem., 293, 2018
2G7R
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BU of 2g7r by Molmil
X-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1
Descriptor: Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Authors:Walker, J.R, Wybenga-Groot, L, Newman, E.M, Finerty Jr, P.J, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2006-02-28
Release date:2006-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1
To be Published
7U8D
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BU of 7u8d by Molmil
FKBP12 mutant V55G bound to Rapa*-3Z
Descriptor: (3S,5Z,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5-(ethoxyimino)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP1A
Authors:Wassarman, D.R, Shokat, K.M.
Deposit date:2022-03-08
Release date:2022-09-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Tissue-restricted inhibition of mTOR using chemical genetics.
Proc.Natl.Acad.Sci.USA, 119, 2022
7AAO
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BU of 7aao by Molmil
Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2
Descriptor: U2 snRNP auxiliary factor large subunit
Authors:Kawale, A.A, Kang, H.S, Sattler, M.
Deposit date:2020-09-04
Release date:2021-10-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2
To Be Published
7AAF
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BU of 7aaf by Molmil
Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2
Descriptor: U2 snRNP auxiliary factor large subunit
Authors:Kawale, A.A, Kang, H.S, Sattler, M.
Deposit date:2020-09-04
Release date:2021-10-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2
To Be Published
1WYR
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BU of 1wyr by Molmil
Solution structure of the CH domain of human Rho guanine nucleotide exchange factor 6
Descriptor: Rho guanine nucleotide exchange factor 6
Authors:Tomizawa, T, Kigawa, T, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-02-15
Release date:2005-08-15
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the CH domain of human Rho guanine nucleotide exchange factor 6
To be Published
1TPG
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BU of 1tpg by Molmil
F1-G MODULE PAIR RESIDUES 1-91 (C83S) OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (T-PA) (NMR, 298K, PH2.95, REPRESENTATIVE STRUCTURE)
Descriptor: T-PLASMINOGEN ACTIVATOR F1-G
Authors:Smith, B.O, Downing, A.K, Driscoll, P.C, Dudgeon, T.J, Campbell, I.D.
Deposit date:1995-06-14
Release date:1995-09-15
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:The solution structure and backbone dynamics of the fibronectin type I and epidermal growth factor-like pair of modules of tissue-type plasminogen activator.
Structure, 3, 1995
1WI8
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BU of 1wi8 by Molmil
Solution structure of the RNA binding domain of eukaryotic initiation factor 4B
Descriptor: Eukaryotic translation initiation factor 4B
Authors:Suzuki, S, Muto, Y, Nagata, T, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-05-28
Release date:2004-11-28
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the RNA binding domain of eukaryotic initiation factor 4B
To be Published
3LGD
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BU of 3lgd by Molmil
Crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ADA2)
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Adenosine deaminase CECR1, ...
Authors:Zavialov, A.V.
Deposit date:2010-01-20
Release date:2010-02-09
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the growth factor activity of human adenosine deaminase ADA2.
J.Biol.Chem., 285, 2010
2G97
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BU of 2g97 by Molmil
Crystal Structure of Visfatin/Pre-B Cell Colony Enhancing Factor 1/Nicotinamide Phosphoribosyltransferase In Complex with the Specific Inhibitor FK-866
Descriptor: (2E)-N-{4-[1-(benzenecarbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide, Nicotinamide phosphoribosyltransferase
Authors:Kim, M.-K, Eom, S.H.
Deposit date:2006-03-05
Release date:2006-08-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of Visfatin/Pre-B Cell Colony-enhancing Factor 1/Nicotinamide Phosphoribosyltransferase, Free and in Complex with the Anti-cancer Agent FK-866
J.Mol.Biol., 362, 2006
1F9P
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BU of 1f9p by Molmil
CRYSTAL STRUCTURE OF CONNECTIVE TISSUE ACTIVATING PEPTIDE-III(CTAP-III) COMPLEXED WITH POLYVINYLSULFONIC ACID
Descriptor: CONNECTIVE TISSUE ACTIVATING PEPTIDE-III, ETHANESULFONIC ACID
Authors:Yang, J, Faulk, T, Aster, R, Visentin, G, Edwards, B, Castor, C.
Deposit date:2000-07-11
Release date:2003-08-26
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structure of the CXC Chemokine, Connective Tissue Activating Peptide-III, Complexed with the Heparin Analogue, Polyvinylsulfonic Acid
To be Published
4RU2
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BU of 4ru2 by Molmil
Crystal structure of a RNA-binding protein 39 (RBM39) in complex with fragment of splicing factor (U2AF) from Mus musculus at 2.20 A resolution
Descriptor: RNA-binding protein 39 (RBM39), Splicing factor U2AF 65 kDa subunit
Authors:Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL)
Deposit date:2014-11-17
Release date:2015-02-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of a RNA-binding protein 39 (RBM39) in complex with fragment of splicing factor (U2AF) from Mus musculus at 2.20 A resolution
To be published
5NTU
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BU of 5ntu by Molmil
Crystal Structure of human Pro-myostatin Precursor at 2.6 A Resolution
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Growth/differentiation factor 8
Authors:Cotton, T.R, Fischer, G, Hyvonen, M.
Deposit date:2017-04-28
Release date:2018-01-17
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structure of the human myostatin precursor and determinants of growth factor latency.
EMBO J., 37, 2018
5NXS
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BU of 5nxs by Molmil
Crystal Structure of Human Pro-myostatin Precursor at 4.2 A Resolution with Experimental Phases from SeMet labelling
Descriptor: Growth/differentiation factor 8
Authors:Cotton, T.R, Fischer, G, Hyvonen, M.
Deposit date:2017-05-10
Release date:2018-01-17
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (4.19 Å)
Cite:Structure of the human myostatin precursor and determinants of growth factor latency.
EMBO J., 37, 2018
5VQF
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BU of 5vqf by Molmil
Crystal Structure of pro-TGF-beta 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Transforming growth factor beta-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Zhao, B, Xu, S, Dong, X, Lu, C, Springer, T.A.
Deposit date:2017-05-08
Release date:2017-11-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Prodomain-growth factor swapping in the structure of pro-TGF-beta 1.
J. Biol. Chem., 293, 2018

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