PDB: 45953 resultsInfo pagesStatus searchChemie searchBIRD

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8GCJ	PCNA Descriptor: Proliferating cell nuclear antigen Authors: Vandborg, B.C, Bruning, J.B. Deposit date: 2023-03-01 Release date: 2024-05-29 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Crystal structure of apo pcna To Be Published
6R6P	Structure of XBP1u-paused ribosome nascent chain complex (rotated state) Descriptor: 18S rRNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... Authors: Shanmuganathan, V, Cheng, J, Berninghausen, O, Beckmann, R. Deposit date: 2019-03-27 Release date: 2019-07-10 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
6R6G	Structure of XBP1u-paused ribosome nascent chain complex with SRP. Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... Authors: Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. Deposit date: 2019-03-27 Release date: 2019-07-10 Last modified: 2019-10-30 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
6R7Q	Structure of XBP1u-paused ribosome nascent chain complex with Sec61. Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... Authors: Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. Deposit date: 2019-03-29 Release date: 2019-07-10 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
6R5Q	Structure of XBP1u-paused ribosome nascent chain complex (post-state) Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... Authors: Shanmuganathan, V, Cheng, J, Berninghausen, O, Beckmann, R. Deposit date: 2019-03-25 Release date: 2019-07-10 Last modified: 2019-10-30 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
4V9O	Control of ribosomal subunit rotation by elongation factor G Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... Authors: Pulk, A, Cate, J.H.D. Deposit date: 2013-05-03 Release date: 2014-07-09 Last modified: 2014-12-17 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Control of ribosomal subunit rotation by elongation factor G. Science, 340, 2013
8B54	CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR6768 Descriptor: 1,2-ETHANEDIOL, Cyclin-A2, Cyclin-dependent kinase 2, ... Authors: Djukic, S, Skerlova, J, Rezacova, P. Deposit date: 2022-09-21 Release date: 2023-03-29 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7. Biomed Pharmacother, 161, 2023
4UXN	LSD1(KDM1A)-CoREST in complex with Z-Pro derivative of MC2580 Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, ... Authors: Rodriguez, V, Valente, S, Stazi, G, Lucidi, A, Mercurio, C, Vianello, P, Ciossani, G, Mattevi, A, Botrugno, O.A, Dessanti, P, Minucci, S, Varasi, M, Mai, A. Deposit date: 2014-08-27 Release date: 2015-02-25 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Pyrrole- and Indole-Containing Tranylcypromine Derivatives as Novel Lysine-Specific Demethylase 1 Inhibitors Active on Cancer Cells Chemmedchem, 6, 2015
4V9P	Control of ribosomal subunit rotation by elongation factor G Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... Authors: Pulk, A, Cate, J.H.D. Deposit date: 2013-05-03 Release date: 2014-07-09 Last modified: 2014-12-17 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Control of ribosomal subunit rotation by elongation factor G. Science, 340, 2013
7R3W	Crystal structure of the albicidin resistance protein STM3175 from Salmonella typhimurium Descriptor: Putative bacterial regulatory helix-turn-helix protein Authors: Dimos, N, Kosol, S, Suessmuth, R, Loll, B. Deposit date: 2022-02-08 Release date: 2022-09-28 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Gene amplifications cause high-level resistance against albicidin in gram-negative bacteria. Plos Biol., 21, 2023
1VQA	GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ALA 35 AND ILE 47 REPLACED BY LEU 47 (V35A, I47L) Descriptor: GENE V PROTEIN Authors: Skinner, M.M, Terwilliger, T.C. Deposit date: 1996-08-14 Release date: 1997-02-12 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Potential use of additivity of mutational effects in simplifying protein engineering. Proc.Natl.Acad.Sci.USA, 93, 1996
1VQH	GENE V PROTEIN MUTANT WITH ILE 47 REPLACED BY MET 47 (I47M) Descriptor: GENE V PROTEIN Authors: Skinner, M.M, Terwilliger, T.C. Deposit date: 1996-08-14 Release date: 1997-02-12 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Potential use of additivity of mutational effects in simplifying protein engineering. Proc.Natl.Acad.Sci.USA, 93, 1996
1W0X	Crystal structure of human CDK2 in complex with the inhibitor olomoucine. Descriptor: CYCLIN-DEPENDENT KINASE 2, OLOMOUCINE Authors: Schulze-Gahmen, U, Meijer, L, Kim, S.-H. Deposit date: 2004-06-14 Release date: 2005-01-14 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Multiple Modes of Ligand Recognition: Crystal Structures of Cyclin-Dependent Protein Kinase 2 in Complex with ATP and Two Inhibitors, Olomoucine and Isopentenyladenine. Proteins, 22, 1995
1VQG	GENE V PROTEIN MUTANT WITH ILE 47 REPLACED BY LEU 47 (I47L) Descriptor: GENE V PROTEIN Authors: Skinner, M.M, Terwilliger, T.C. Deposit date: 1996-08-14 Release date: 1997-02-12 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Potential use of additivity of mutational effects in simplifying protein engineering. Proc.Natl.Acad.Sci.USA, 93, 1996
1VQD	GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY LEU 47 (V35I, I47L) Descriptor: GENE V PROTEIN Authors: Skinner, M.M, Terwilliger, T.C. Deposit date: 1996-08-14 Release date: 1997-02-12 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Potential use of additivity of mutational effects in simplifying protein engineering. Proc.Natl.Acad.Sci.USA, 93, 1996
1VQI	GENE V PROTEIN MUTANT WITH ILE 47 REPLACED BY VAL 47 (I47V) Descriptor: GENE V PROTEIN Authors: Zhang, H, Skinner, M.M, Sandberg, W.S, Wang, A.H.-J, Terwilliger, T.C. Deposit date: 1996-08-14 Release date: 1997-02-12 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Context dependence of mutational effects in a protein: the crystal structures of the V35I, I47V and V35I/I47V gene V protein core mutants. J.Mol.Biol., 259, 1996
1VQE	GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY MET 47 (V35I, I47M) Descriptor: GENE V PROTEIN Authors: Skinner, M.M, Terwilliger, T.C. Deposit date: 1996-08-14 Release date: 1997-02-12 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Potential use of additivity of mutational effects in simplifying protein engineering. Proc.Natl.Acad.Sci.USA, 93, 1996
1VQF	GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY VAL 47 (V35I, I47V) Descriptor: GENE V PROTEIN Authors: Zhang, H, Skinner, M.M, Sandberg, W.S, Wang, A.H.-J, Terwilliger, T.C. Deposit date: 1996-08-14 Release date: 1997-02-12 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Context dependence of mutational effects in a protein: the crystal structures of the V35I, I47V and V35I/I47V gene V protein core mutants. J.Mol.Biol., 259, 1996
1VQC	GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY PHE 47 (V35I, I47F) Descriptor: GENE V PROTEIN Authors: Skinner, M.M, Terwilliger, T.C. Deposit date: 1996-08-14 Release date: 1997-02-12 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Potential use of additivity of mutational effects in simplifying protein engineering. Proc.Natl.Acad.Sci.USA, 93, 1996
1W98	The structural basis of CDK2 activation by cyclin E Descriptor: CELL DIVISION PROTEIN KINASE 2, G1/S-SPECIFIC CYCLIN E1 Authors: Lowe, E.D, Honda, R, Dubinina, E, Skamnaki, V, Cook, A, Johnson, L.N. Deposit date: 2004-10-07 Release date: 2005-02-02 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: The Structure of Cyclin E1/Cdk2: Implications for Cdk2 Activation and Cdk2-Independent Roles Embo J., 24, 2005
3UNJ	CDK2 in complex with inhibitor YL1-038-31 Descriptor: 4-{[4-(phenylamino)pyrimidin-2-yl]amino}benzoic acid, Cyclin-dependent kinase 2, PHOSPHATE ION Authors: Zhu, J.-Y, Martin, M.P, Alam, R, Schonbrunn, E. Deposit date: 2011-11-15 Release date: 2012-01-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9001 Å) Cite: A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A. Acs Chem.Biol., 7, 2012
3ULI	Human Cyclin Dependent Kinase 2 (CDK2) bound to azabenzimidazole derivative Descriptor: 1-(aminomethyl)-N-(3-{[6-bromo-2-(4-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-7-yl]amino}propyl)cyclopropanecarboxamide, Cyclin-dependent kinase 2 Authors: Larsen, N.A, Tucker, J.A, Wang, T. Deposit date: 2011-11-10 Release date: 2013-08-14 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKK epsilon kinases. Bioorg.Med.Chem.Lett., 22, 2012
1W8C	CO-CRYSTAL STRUCTURE OF 6-CYCLOHEXYLMETHOXY-8-ISOPROPYL-9H-PURIN-2- YLAMINE AND MONOMERIC CDK2 Descriptor: 6-(CYCLOHEXYLMETHOXY)-8-ISOPROPYL-9H-PURIN-2-AMINE, CELL DIVISION PROTEIN KINASE 2 Authors: Pratt, D.J, Endicott, J.A, Noble, M.E.M. Deposit date: 2004-09-20 Release date: 2006-08-30 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.05 Å) Cite: 8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode. J.Med.Chem., 57, 2014
1VYW	Structure of CDK2/Cyclin A with PNU-292137 Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, N-(3-CYCLOPROPYL-1H-PYRAZOL-5-YL)-2-(2-NAPHTHYL)ACETAMIDE, ... Authors: Pevarello, P, Brasca, M.G, Amici, R, Orsini, P, Traquandi, G, Corti, L, Piutti, C, Sansonna, P, Villa, M, Pierce, B.S, Pulici, M, Giordano, P, Martina, K, Fritzen, E.L, Nugent, R.A, Casale, E, Cameron, A, Ciomei, M, Roletto, F, Isacchi, A, Fogliatto, G, Pesenti, E, Pastori, W, Marsiglio, A, Leach, K.L, Clare, P.M, Fiorentini, F, Varasi, M, Vulpetti, A, Warpehoski, M.A. Deposit date: 2004-05-07 Release date: 2004-06-10 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: 3-Aminopyrazole Inhibitors of Cdk2/Cyclin a as Antitumor Agents. Part 1. Lead Finding J.Med.Chem., 47, 2004
1VYZ	Structure of CDK2 complexed with PNU-181227 Descriptor: CELL DIVISION PROTEIN KINASE 2, N-(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)BENZAMIDE Authors: Pevarello, P, Brasca, M.G, Amici, R, Orsini, P, Traquandi, G, Corti, L, Piutti, C, Sansonna, P, Villa, M, Pierce, B.S, Pulici, M, Giordano, G, Martina, K, Lfritzen, E, Nugent, R.A, Casale, E, Cameron, A, Ciomei, M, Roletto, F, Isacchi, A, Fogliatto, G, Pesenti, E, Pastori, W, Marsiglio, W, Leach, K.L, Clare, P.M, Fiorentini, F, Varasi, M, Vulpetti, A, Warpehoski, M.A. Deposit date: 2004-05-07 Release date: 2004-06-17 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.21 Å) Cite: 3-Aminopyrazole Inhibitors of Cdk2/Cyclin a as Antitumor Agents. 1. Lead Finding J.Med.Chem., 47, 2004

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