6KBR
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5L1F
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![BU of 5l1f by Molmil](/molmil-images/mine/5l1f) | AMPA subtype ionotropic glutamate receptor GluA2 in complex with noncompetitive inhibitor Perampanel | Descriptor: | 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2 | Authors: | Yelshanskaya, M.V, Singh, A.K, Sampson, J.M, Sobolevsky, A.I. | Deposit date: | 2016-07-29 | Release date: | 2016-10-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs. Neuron, 91, 2016
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6S2J
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8TT1
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6B9E
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![BU of 6b9e by Molmil](/molmil-images/mine/6b9e) | Human ATL1 mutant - R77A / F151S bound to GDP | Descriptor: | Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | O'Donnell, J.P, Sondermann, H. | Deposit date: | 2017-10-10 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core. J. Biol. Chem., 293, 2018
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1GUN
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8B9W
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![BU of 8b9w by Molmil](/molmil-images/mine/8b9w) | Cysteine Synthase from Trypanosoma theileri with PLP bound | Descriptor: | CHLORIDE ION, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Sowerby, K.V, Pohl, E. | Deposit date: | 2022-10-10 | Release date: | 2023-05-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis. Acta Crystallogr D Struct Biol, 79, 2023
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8B9M
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![BU of 8b9m by Molmil](/molmil-images/mine/8b9m) | Cysteine Synthase from Leishmania Infantum | Descriptor: | CHLORIDE ION, Cysteine synthase, GLYCEROL | Authors: | Sowerby, K.V, Pohl, E. | Deposit date: | 2022-10-06 | Release date: | 2023-05-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis. Acta Crystallogr D Struct Biol, 79, 2023
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5N6X
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![BU of 5n6x by Molmil](/molmil-images/mine/5n6x) | Crystal structure of the Legionella effector WipA | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, BETA-MERCAPTOETHANOL, BROMIDE ION, ... | Authors: | Pinotsis, N, Waksman, G. | Deposit date: | 2017-02-16 | Release date: | 2017-04-19 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure of the WipA protein reveals a novel tyrosine protein phosphatase effector from Legionella pneumophila. J. Biol. Chem., 292, 2017
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8BLQ
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5L0D
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![BU of 5l0d by Molmil](/molmil-images/mine/5l0d) | Human Metavinculin(residues 959-1130) in complex with PIP2 | Descriptor: | Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Chinthalapudi, K, Izard, T. | Deposit date: | 2016-07-27 | Release date: | 2016-08-31 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization. Proc.Natl.Acad.Sci.USA, 113, 2016
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2OFQ
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![BU of 2ofq by Molmil](/molmil-images/mine/2ofq) | NMR Solution Structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system | Descriptor: | TraN, TraO | Authors: | Harris, R, Bayliss, R, Driscoll, P.C, Waksman, G. | Deposit date: | 2007-01-04 | Release date: | 2007-01-23 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system Proc.Natl.Acad.Sci.Usa, 104, 2007
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6OAX
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![BU of 6oax by Molmil](/molmil-images/mine/6oax) | Structure of the hyperactive ClpB mutant K476C, bound to casein, pre-state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Alpha-S1-casein, Hyperactive disaggregase ClpB, ... | Authors: | Rizo, A.R, Lin, J.-B, Gates, S.N, Tse, E, Bart, S.M, Castellano, L.M, Dimaio, F, Shorter, J, Southworth, D.R. | Deposit date: | 2019-03-18 | Release date: | 2019-06-12 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase. Nat Commun, 10, 2019
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2GJ3
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![BU of 2gj3 by Molmil](/molmil-images/mine/2gj3) | Crystal structure of the FAD-containing PAS domain of the protein NifL from Azotobacter vinelandii. | Descriptor: | ETHANOL, FLAVIN-ADENINE DINUCLEOTIDE, Nitrogen fixation regulatory protein, ... | Authors: | Key, J, Hefti, M, Purcell, E, Moffat, K. | Deposit date: | 2006-03-30 | Release date: | 2007-03-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.04 Å) | Cite: | Structure of the redox sensor domain of Azotobacter vinelandii NifL at atomic resolution: signaling, dimerization, and mechanism. Biochemistry, 46, 2007
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1CR5
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![BU of 1cr5 by Molmil](/molmil-images/mine/1cr5) | N-TERMINAL DOMAIN OF SEC18P | Descriptor: | 1-ETHYL-PYRROLIDINE-2,5-DIONE, SEC18P (RESIDUES 22 - 210) | Authors: | Babor, S.M, Fass, D. | Deposit date: | 1999-08-13 | Release date: | 1999-12-22 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the Sec18p N-terminal domain. Proc.Natl.Acad.Sci.USA, 96, 1999
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6RKT
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![BU of 6rkt by Molmil](/molmil-images/mine/6rkt) | Crystal Structure of TGT in complex with N2-methyl-1H,7H,8H-imidazo[4,5-g]quinazoline-2,6-diamine | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | Authors: | Hassaan, E, Heine, A, Klebe, G. | Deposit date: | 2019-04-30 | Release date: | 2020-06-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.746 Å) | Cite: | Fragment Screening Hit Draws Attention to a Novel Transient Pocket Adjacent to the Recognition Site of the tRNA-Modifying Enzyme TGT. J.Med.Chem., 63, 2020
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8IQY
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8R3L
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![BU of 8r3l by Molmil](/molmil-images/mine/8r3l) | Influenza A/H7N9 polymerase in pre-initiation state, intermediate conformation (I) with PB2-C(I), ENDO(T), and Pol II pS5 CTD peptide mimic bound in site 1A/2A | Descriptor: | 3' vRNA end (51-mer vRNA loop), Polymerase acidic protein, Polymerase basic protein 2, ... | Authors: | Arragain, B, Cusack, S. | Deposit date: | 2023-11-09 | Release date: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
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8IQW
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8IQV
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8IQZ
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6RUU
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![BU of 6ruu by Molmil](/molmil-images/mine/6ruu) | Pseudokinase domain of human IRAK3 | Descriptor: | GLYCEROL, Interleukin-1 receptor-associated kinase 3, MERCURY (II) ION, ... | Authors: | Lange, S.M, Kulathu, Y, Cohen, P. | Deposit date: | 2019-05-29 | Release date: | 2020-09-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation. Structure, 29, 2021
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6OJT
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![BU of 6ojt by Molmil](/molmil-images/mine/6ojt) | Crystal structure of Sphingomonas paucimobilis TMY1009 LsdA phenylazophenol complex | Descriptor: | 4-Hydroxyazobenzene, FE (III) ION, Lignostilbene-alpha,beta-dioxygenase isozyme I | Authors: | Kuatsjah, E, Verstraete, M.M, Kobylarz, M.J, Liu, A.K.N, Murphy, M.E.P, Eltis, L.D. | Deposit date: | 2019-04-12 | Release date: | 2019-07-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Identification of functionally important residues and structural features in a bacterial lignostilbene dioxygenase. J.Biol.Chem., 294, 2019
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6RX3
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![BU of 6rx3 by Molmil](/molmil-images/mine/6rx3) | Crystal structure of human syncytin 2 in post-fusion conformation | Descriptor: | CHLORIDE ION, Syncytin-2 | Authors: | Ruigrok, K, Backovic, M, Vaney, M.C, Rey, F.A. | Deposit date: | 2019-06-07 | Release date: | 2019-11-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | X-ray Structures of the Post-fusion 6-Helix Bundle of the Human Syncytins and their Functional Implications. J.Mol.Biol., 431, 2019
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5IIR
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