7O4R
 
 | | Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme with Coenzyme A bound at the thiolase active sites and additional binding site (CoA(HAD/KAT)) | | Descriptor: | 3-hydroxyacyl-CoA dehydrogenase, COENZYME A, GLYCEROL, ... | | Authors: | Dalwani, S, Wierenga, R.K, Venkatesan, R. | | Deposit date: | 2021-04-07 | | Release date: | 2021-08-25 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | Substrate specificity and conformational flexibility properties of the Mycobacterium tuberculosis beta-oxidation trifunctional enzyme.
J.Struct.Biol., 213, 2021
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1ZL5
 | | Crystal structure of Glu335Gln mutant of Clostridium botulinum neurotoxin E catalytic domain | | Descriptor: | CHLORIDE ION, botulinum neurotoxin type E | | Authors: | Agarwal, R, Binz, T, Swaminathan, S. | | Deposit date: | 2005-05-05 | | Release date: | 2005-07-05 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Analysis of Active Site Residues of Botulinum Neurotoxin E by Mutational, Functional, and Structural Studies: Glu335Gln Is an Apoenzyme.
Biochemistry, 44, 2005
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2E9X
 | | The crystal structure of human GINS core complex | | Descriptor: | DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, GINS complex subunit 3, ... | | Authors: | Kamada, K, Hanaoka, F. | | Deposit date: | 2007-01-27 | | Release date: | 2007-04-10 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of the human GINS complex and its assembly and functional interface in replication initiation
Nat.Struct.Mol.Biol., 14, 2007
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3HNK
 | | Crystal structure of the dimeric assembly of the cyt cb562 variant RIDC-1 | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Soluble cytochrome b562 | | Authors: | Salgado, E.N, Lewis, R.A, Brodin, J, Tezcan, F.A. | | Deposit date: | 2009-05-31 | | Release date: | 2010-02-09 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Metal templated design of protein interfaces.
Proc.Natl.Acad.Sci.USA, 107, 2010
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7A0L
 | | Joint neutron/X-ray room temperature structure of perdeuterated Aspergillus flavus urate oxidase in complex with the 8-azaxanthine inhibitor and catalytic water bound in the peroxo hole | | Descriptor: | 8-AZAXANTHINE, SODIUM ION, Uricase | | Authors: | McGregor, L, Bui, S, Blakeley, M.P, Steiner, R.A. | | Deposit date: | 2020-08-09 | | Release date: | 2020-12-09 | | Last modified: | 2024-05-01 | | Method: | NEUTRON DIFFRACTION (1.33 Å), X-RAY DIFFRACTION | | Cite: | Joint neutron/X-ray crystal structure of a mechanistically relevant complex of perdeuterated urate oxidase and simulations provide insight into the hydration step of catalysis.
Iucrj, 8, 2021
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5VBX
 | | Crystal structure of holo-[acyl-carrier-protein] synthase (AcpS) from Escherichia coli | | Descriptor: | 1,2-ETHANEDIOL, Holo-[acyl-carrier-protein] synthase, SODIUM ION | | Authors: | Marcella, A.M, Barb, A.W. | | Deposit date: | 2017-03-30 | | Release date: | 2017-11-01 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structure, High Affinity, and Negative Cooperativity of the Escherichia coli Holo-(Acyl Carrier Protein):Holo-(Acyl Carrier Protein) Synthase Complex.
J. Mol. Biol., 429, 2017
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5VCF
 | | RNA hairpin structure containing tetraloop/receptor motif, complexed with 2-MeImpG analogue | | Descriptor: | 5'-O-[(S)-hydroxy(4-methyl-1H-imidazol-5-yl)phosphoryl]guanosine, RNA (5'-R(*CP*UP*AP*UP*GP*CP*CP*UP*GP*CP*UP*G)-3'), RNA (5'-R(*CP*UP*GP*CP*UP*GP*GP*CP*UP*AP*AP*GP*GP*CP*CP*CP*GP*AP*AP*AP*GP*G)-3') | | Authors: | Zhang, W, Szostak, J.W. | | Deposit date: | 2017-03-31 | | Release date: | 2018-02-21 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide.
J. Am. Chem. Soc., 140, 2018
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5X5I
 | | The X-ray crystal structure of a TetR family transcription regulator RcdA involved in the regulation of biofilm formation in Escherichia coli | | Descriptor: | HTH-type transcriptional regulator RcdA | | Authors: | Sugino, H, Usui, M, Shimada, T, Nakano, M, Ogasawara, H, Ishihama, A, Hirata, A. | | Deposit date: | 2017-02-16 | | Release date: | 2017-12-27 | | Method: | X-RAY DIFFRACTION (2.554 Å) | | Cite: | A structural sketch of RcdA, a transcription factor controlling the master regulator of biofilm formation.
FEBS Lett., 591, 2017
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1CX9
 | | CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-AMINOPHENYLTHIO)-BUTYLPHOSPHONIC ACID | | Descriptor: | 4-(2-AMINOPHENYLTHIO)-BUTYLPHOSPHONIC ACID, PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, ... | | Authors: | Sachpatzidis, A, Dealwis, C, Lubetsky, J.B, Liang, P.H, Anderson, K.S, Lolis, E. | | Deposit date: | 1999-08-29 | | Release date: | 1999-12-29 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase.
Biochemistry, 38, 1999
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1D9E
 | | STRUCTURE OF E. COLI KDO8P SYNTHASE | | Descriptor: | 3-DEOXY-D-MANNO-OCTULOSONATE 8-PHOSPHATE SYNTHASE, SULFATE ION | | Authors: | Radaev, S, Dastidar, P, Patel, M, Woodard, R.W, Gatti, D.L. | | Deposit date: | 1999-10-27 | | Release date: | 2000-05-10 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure and mechanism of 3-deoxy-D-manno-octulosonate 8-phosphate synthase.
J.Biol.Chem., 275, 2000
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1CJX
 | | CRYSTAL STRUCTURE OF PSEUDOMONAS FLUORESCENS HPPD | | Descriptor: | 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE, ACETATE ION, ETHYL MERCURY ION, ... | | Authors: | Serre, L, Sailland, A, Sy, D, Boudec, P, Rolland, A, Pebay-Peroulla, E, Cohen-Addad, C. | | Deposit date: | 1999-04-20 | | Release date: | 2000-04-26 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: an enzyme involved in the tyrosine degradation pathway.
Structure Fold.Des., 7, 1999
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1CMX
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2AXU
 | | Structure of PrgX | | Descriptor: | PrgX | | Authors: | Shi, K, Brown, C.K, Gu, Z.Y, Kozlowicz, B.K, Dunny, G.M, Ohlendorf, D.H, Earhart, C.A. | | Deposit date: | 2005-09-06 | | Release date: | 2005-12-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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7AOI
 | | Trypanosoma brucei mitochondrial ribosome large subunit assembly intermediate | | Descriptor: | 50S ribosomal protein L13, 50S ribosomal protein L14, 50S ribosomal protein L17, ... | | Authors: | Tobiasson, V, Gahura, O, Aibara, S, Baradaran, R, Zikova, A, Amunts, A. | | Deposit date: | 2020-10-14 | | Release date: | 2020-12-02 | | Last modified: | 2021-03-24 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit.
Embo J., 40, 2021
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5OPH
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1APZ
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7CD0
 | | Crystal structure of the 2-iodoporphobilinogen-bound ES2 intermediate form of human hydroxymethylbilane synthase | | Descriptor: | 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid, 3-[5-(aminomethyl)-4-(carboxymethyl)-2-iodo-1H-pyrrol-3-yl]propanoic acid, Porphobilinogen deaminase | | Authors: | Sato, H, Sugishima, M, Wada, K, Hirabayashi, K, Tsukaguchi, M. | | Deposit date: | 2020-06-18 | | Release date: | 2021-03-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps.
Biochem.J., 478, 2021
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7CCZ
 | | Crystal structure of the ES2 intermediate form of human hydroxymethylbilane synthase | | Descriptor: | 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid, Porphobilinogen deaminase | | Authors: | Sato, H, Sugishima, M, Wada, K, Hirabayashi, K, Tsukaguchi, M. | | Deposit date: | 2020-06-18 | | Release date: | 2021-03-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps.
Biochem.J., 478, 2021
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7CCX
 | | Crystal structure of the holo form of human hydroxymethylbilane synthase | | Descriptor: | 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, Porphobilinogen deaminase | | Authors: | Sato, H, Sugishima, M, Wada, K, Hirabayashi, K, Tsukaguchi, M. | | Deposit date: | 2020-06-18 | | Release date: | 2021-03-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps.
Biochem.J., 478, 2021
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1ZZJ
 | | Structure of the third KH domain of hnRNP K in complex with 15-mer ssDNA | | Descriptor: | 5'-D(*TP*TP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*TP*TP*T)-3', Heterogeneous nuclear ribonucleoprotein K | | Authors: | Backe, P.H, Messias, A.C, Ravelli, R.B, Sattler, M, Cusack, S. | | Deposit date: | 2005-06-14 | | Release date: | 2005-08-09 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | X-Ray Crystallographic and NMR Studies of the Third KH Domain of hnRNP K in Complex with Single-Stranded Nucleic Acids
STRUCTURE, 13, 2005
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7CCY
 | | Crystal structure of the 2-iodoporphobilinogen-bound holo form of human hydroxymethylbilane synthase | | Descriptor: | 3-[5-(aminomethyl)-4-(carboxymethyl)-2-iodo-1H-pyrrol-3-yl]propanoic acid, 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, Porphobilinogen deaminase | | Authors: | Sato, H, Sugishima, M, Wada, K, Hirabayashi, K, Tsukaguchi, M. | | Deposit date: | 2020-06-18 | | Release date: | 2021-03-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps.
Biochem.J., 478, 2021
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6HOF
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6RL2
 | | The crystal structure of AbnE, an arabino-oligosaccharide binding protein, in complex with arabinotetraose | | Descriptor: | Arabino-oligosaccharids-binding protein, CALCIUM ION, GLYCEROL, ... | | Authors: | Lansky, S, Salama, R, Shoham, Y, Shoham, G. | | Deposit date: | 2019-05-01 | | Release date: | 2020-04-15 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Carbohydrate-Binding Capability and Functional Conformational Changes of AbnE, an Arabino-oligosaccharide Binding Protein.
J.Mol.Biol., 432, 2020
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5TGZ
 | | Crystal Structure of the Human Cannabinoid Receptor CB1 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-[4-[2-(2,4-dichlorophenyl)-4-methyl-5-(piperidin-1-ylcarbamoyl)pyrazol-3-yl]phenyl]but-3-ynyl nitrate, Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, ... | | Authors: | Hua, T, Vemuri, K, Pu, M, Qu, L, Han, G.W, Wu, Y, Zhao, S, Shui, W, Li, S, Korde, A, Laprairie, R.B, Stahl, E.L, Ho, J.H, Zvonok, N, Zhou, H, Kufareva, I, Wu, B, Zhao, Q, Hanson, M.A, Bohn, L.M, Makriyannis, A, Stevens, R.C, Liu, Z.J. | | Deposit date: | 2016-09-28 | | Release date: | 2016-11-02 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal Structure of the Human Cannabinoid Receptor CB1.
Cell, 167, 2016
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2AWI
 | | Structure of PrgX Y153C mutant | | Descriptor: | PrgX | | Authors: | Shi, K, Brown, C.K, Gu, Z.Y, Kozlowicz, B.k, Dunny, G.M, Ohlendorf, D.H, Earhart, C.A. | | Deposit date: | 2005-09-01 | | Release date: | 2005-12-06 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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