5OPH

G-quadruplex structure of DNA oligonucleotide containing GGGGCC repeats linked to ALS and FTD

Summary for 5OPH

• Entry DOI: 10.2210/pdb5oph/pdb
• NMR Information: BMRB: 34168
• Descriptor: DNA (5'-D(*GP*GP*GP*GP*CP*CP*GP*GP*GP*GP*CP*CP*GP*GP*GP*GP*CP*CP*GP*GP*(BGM)P*G)-3') (1 entity in total)
• Functional Keywords: g-quadruplex, dna, nucelar magnetic resonance, k+ solution, antiparallel, four g-quartets, edgewise loops, stacking, ggggcc-repat, als and ftd, neurodegenerative disorders, repetitive sequences, nucleic acid, 8br-dg, modified residue
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 7036.32

Authors

Brcic, J.,Plavec, J. (deposition date: 2017-08-09, release date: 2018-08-29, Last modification date: 2019-06-19)

• Primary citation: Brcic, J.,Plavec, J.; NMR structure of a G-quadruplex formed by four d(G4C2) repeats: insights into structural polymorphism.; Nucleic Acids Res., 46:11605-11617, 2018; PubMed: 30277522; DOI: 10.1093/nar/gky886

Experimental method

SOLUTION NMR