7CD0

Crystal structure of the 2-iodoporphobilinogen-bound ES2 intermediate form of human hydroxymethylbilane synthase

Summary for 7CD0

• Entry DOI: 10.2210/pdb7cd0/pdb
• Descriptor: Porphobilinogen deaminase, 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid, 3-[5-(aminomethyl)-4-(carboxymethyl)-2-iodo-1H-pyrrol-3-yl]propanoic acid, ... (4 entities in total)
• Functional Keywords: porphyrin synthesis, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 80795.77

Authors

Sato, H.,Sugishima, M.,Wada, K.,Hirabayashi, K.,Tsukaguchi, M. (deposition date: 2020-06-18, release date: 2021-03-17, Last modification date: 2023-11-29)

• Primary citation: Sato, H.,Sugishima, M.,Tsukaguchi, M.,Masuko, T.,Iijima, M.,Takano, M.,Omata, Y.,Hirabayashi, K.,Wada, K.,Hisaeda, Y.,Yamamoto, K.; Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps.; Biochem.J., 478:1023-1042, 2021; PubMed: 33600566; DOI: 10.1042/BCJ20200996

Experimental method

X-RAY DIFFRACTION (2.31 Å)