7CD0

Crystal structure of the 2-iodoporphobilinogen-bound ES2 intermediate form of human hydroxymethylbilane synthase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Porphobilinogen deaminase	polymer	361	39383.0	2	UniProt (P08397) Pfam (PF01379) Pfam (PF03900)	Homo sapiens (Human)	PBG-D,Hydroxymethylbilane synthase,HMBS,Pre-uroporphyrinogen synthase
2	C, D (A, B)	3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid	non-polymer		838.8	2	Chemie (7J8)
3	E (B)	3-[5-(aminomethyl)-4-(carboxymethyl)-2-iodo-1H-pyrrol-3-yl]propanoic acid	non-polymer		352.1	1	Chemie (FWL)
4	F, G (A, B)	water	water		18.0	76	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	78766.0
Non-Polymers*	Number of molecules	3
	Total formula weight	2029.7
All*	Total formula weight	80795.8

*Water molecules are not included.