PDB: 224004 resultsInfo pagesStatus searchChemie searchBIRD

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4OME	X-ray structure of human glutamate carboxypeptidase II in complex with DCCBL, a urea based inhibitor with distal carborane moiety Descriptor: (S)-2-(3-((S)-1-carboxy-5-(1,2-dicarba-closo-dodecarboranylamido) pentyl)ureido)pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Barinka, C, Ptacek, J, Novakova, Z, Byun, Y. Deposit date: 2014-01-27 Release date: 2015-02-18 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.79 Å) Cite: X-ray structure of human glutamate carboxypeptidase II in complex with DCCBL, a urea based inhibitor with distal carborane moiety To be Published
3UQO	Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor Descriptor: 3-(3-carbamimidoylphenyl)-N-(2'-sulfamoylbiphenyl-4-yl)-1,2-oxazole-4-carboxamide, CALCIUM ION, Cationic trypsin Authors: Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. Deposit date: 2011-11-21 Release date: 2012-11-21 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
4OLV	Crystal structure of antibody VRC07-G54F in complex with clade A/E 93TH057 HIV-1 gp120 core Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ... Authors: Kwon, Y.D, Kwong, P.D. Deposit date: 2014-01-25 Release date: 2014-09-03 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo. J.Virol., 88, 2014
3UQZ	X-ray structure of DNA processing protein A (DprA) from Streptococcus pneumoniae Descriptor: DNA processing protein DprA, SULFATE ION Authors: Quevillon-Cheruel, S, Brooks, M.A, Li de la Sierra-Gallay, I. Deposit date: 2011-11-21 Release date: 2012-08-29 Last modified: 2012-09-26 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structure-function analysis of pneumococcal DprA protein reveals that dimerization is crucial for loading RecA recombinase onto DNA during transformation. Proc.Natl.Acad.Sci.USA, 109, 2012
2RG0	Crystal structure of cellobiohydrolase from Melanocarpus albomyces complexed with cellotetraose Descriptor: Cellulose 1,4-beta-cellobiosidase, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose Authors: Parkkinen, T, Koivula, A, Vehmaanper, J, Rouvinen, J. Deposit date: 2007-10-02 Release date: 2008-09-16 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of Melanocarpus albomyces cellobiohydrolase Cel7B in complex with cello-oligomers show high flexibility in the substrate binding Protein Sci., 17, 2008
4OMH	Crystal structure of the bacterial diterpene cyclase COTB2 variant F149L Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Geranylgeranyl diphosphate cyclase, SODIUM ION Authors: Janke, R, Goerner, C, Hirte, M, Brueck, T, Loll, B. Deposit date: 2014-01-27 Release date: 2014-06-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.64 Å) Cite: The first structure of a bacterial diterpene cyclase: CotB2. Acta Crystallogr.,Sect.D, 70, 2014
3URB	Crystal Structure of PTE mutant H254G/H257W/L303T/M317L/I106C/F132I/L271I/K185R/I274N/A80V/R67H Descriptor: COBALT (II) ION, DIETHYL HYDROGEN PHOSPHATE, IMIDAZOLE, ... Authors: Tsai, P, Fox, N.G, Li, Y, Barondeau, D.P, Raushel, F.M. Deposit date: 2011-11-21 Release date: 2012-08-01 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Enzymes for the homeland defense: optimizing phosphotriesterase for the hydrolysis of organophosphate nerve agents. Biochemistry, 51, 2012
4OMZ	Crystal Structure of NolR from Sinorhizobium fredii Descriptor: NolR, PHOSPHATE ION Authors: Lee, S.G, Krishnan, H.B, Jez, J.M. Deposit date: 2014-01-28 Release date: 2014-04-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.64 Å) Cite: Structural basis for regulation of rhizobial nodulation and symbiosis gene expression by the regulatory protein NolR. Proc.Natl.Acad.Sci.USA, 111, 2014
3UMY	Crystal structure of mutant ribosomal protein T217A TthL1 in complex with 80nt 23S RNA from Thermus thermophilus Descriptor: 50S ribosomal protein L1, CHLORIDE ION, MAGNESIUM ION, ... Authors: Gabdulkhakov, A.G, Nevskaya, N.A, Nikonov, S.V. Deposit date: 2011-11-15 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of mutant ribosomal protein T217A TthL1 in complex with 80nt 23S RNA from Thermus thermophilus To be Published
4OO7	THE 1.55A CRYSTAL STRUCTURE of NAF1 (MINER1): THE REDOX-ACTIVE 2FE-2S PROTEIN Descriptor: CDGSH iron-sulfur domain-containing protein 2, FE2/S2 (INORGANIC) CLUSTER Authors: Tamir, S, Eisenberg-Domovich, Y, Colman, A.R, Stofleth, J.T, Lipper, C.H, Paddock, M.L, Jenning, P.A, Livnah, O, Nechushtai, R. Deposit date: 2014-01-31 Release date: 2014-07-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.65 Å) Cite: A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties. Acta Crystallogr.,Sect.D, 70, 2014
3URO	Poliovirus receptor CD155 D1D2 Descriptor: Poliovirus receptor Authors: Zhang, P, Mueller, S, Morais, M.C, Bator, C.M, Bowman, V.D, Hafenstein, S, Wimmer, E, Rossmann, M.G. Deposit date: 2011-11-22 Release date: 2011-12-07 Method: X-RAY DIFFRACTION (3.5005 Å) Cite: Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses. Proc.Natl.Acad.Sci.USA, 105, 2008
3US1	Structure of p63 DNA Binding Domain in Complex with a 22 Base Pair Response Element Containing a Two Base Pair "GC" Spacer Between Half Sites Descriptor: 5'-D(*AP*AP*AP*CP*AP*TP*GP*TP*TP*TP*GP*CP*AP*AP*AP*CP*AP*TP*GP*TP*TP*T)-3', Tumor protein 63, ZINC ION Authors: Chen, C, Herzberg, O. Deposit date: 2011-11-22 Release date: 2012-02-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Pliable DNA Conformation of Response Elements Bound to Transcription Factor p63. J.Biol.Chem., 287, 2012
3UNB	Mouse constitutive 20S proteasome in complex with PR-957 Descriptor: 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ... Authors: Huber, E, Basler, M, Schwab, R, Heinemeyer, W, Kirk, C, Groettrup, M, Groll, M. Deposit date: 2011-11-15 Release date: 2012-02-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity. Cell(Cambridge,Mass.), 148, 2012
3USR	Structure of Y194F glycogenin mutant truncated at residue 270 Descriptor: CHLORIDE ION, GLYCEROL, Glycogenin-1 Authors: Issoglio, F.M, Carrizo, M.E, Romero, J.M, Curtino, J.A. Deposit date: 2011-11-23 Release date: 2011-12-14 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Mechanisms of monomeric and dimeric glycogenin autoglucosylation. J.Biol.Chem., 287, 2012
4OOK	Third Metal bound M.tuberculosis methionine aminopeptidase Descriptor: COBALT (II) ION, Methionine aminopeptidase 2, SODIUM ION Authors: Reddi, R, Addlagatta, A. Deposit date: 2014-02-03 Release date: 2015-02-04 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents Febs J., 281, 2014
3USW	Crystal structure of FliG (residues 86-343) from H. pylori Descriptor: Flagellar motor switch protein Authors: Au, S.W.N, Lam, K.H. Deposit date: 2011-11-24 Release date: 2011-12-14 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.601 Å) Cite: Multiple conformations of the FliG C-terminal domain provide insight into flagellar motor switching Structure, 20, 2012
4OOT	X-ray structure of the protein-gold adduct formed upon reaction of Aubipic with hen egg white lysozyme Descriptor: 1,2-ETHANEDIOL, GOLD ION, Lysozyme C, ... Authors: Merlino, A. Deposit date: 2014-02-04 Release date: 2014-12-17 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Protein Recognition of Gold-Based Drugs: 3D Structure of the Complex Formed When Lysozyme Reacts with Aubipy(c.). ACS Med Chem Lett, 5, 2014
3USO	Crystal structure of LeuT bound to L-selenomethionine in space group P21212 from lipid bicelles Descriptor: SELENOMETHIONINE, SODIUM ION, Transporter Authors: Wang, H, Elferich, J, Gouaux, E. Deposit date: 2011-11-23 Release date: 2012-01-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (4.5 Å) Cite: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
4OP5	Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, Extended spectrum beta-lactamase TEM-63, ... Authors: Dellus-Gur, E, Elias, M, Fraser, J.S, Tawfik, D.S. Deposit date: 2014-02-05 Release date: 2015-05-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Negative Epistasis and Evolvability in TEM-1 beta-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder. J. Mol. Biol., 427, 2015
3UTW	Crystal structure of bacteriorhodopsin mutant P50A/Y57F Descriptor: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Bacteriorhodopsin, RETINAL, ... Authors: Cao, Z, Bowie, J.U. Deposit date: 2011-11-27 Release date: 2012-05-09 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Shifting hydrogen bonds may produce flexible transmembrane helices. Proc.Natl.Acad.Sci.USA, 109, 2012
4OPD	Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase. Descriptor: Conserved Archaeal protein, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, GERANYLGERANYL DIPHOSPHATE Authors: McAndrew, R.P, Kung, Y, Xie, X, Liu, C, Pereira, J.H, Keasling, J.D, Adams, P.D. Deposit date: 2014-02-05 Release date: 2014-07-09 Last modified: 2014-07-23 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase. Structure, 22, 2014
3UT4	Structural view of a non Pfam singleton and crystal packing analysis Descriptor: Putative uncharacterized protein Authors: Cheng, C, Shaw, N, Zhang, X, Zhang, M, Ding, W, Wang, B.C, Liu, Z.J. Deposit date: 2011-11-25 Release date: 2012-03-28 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Structural view of a non pfam singleton and crystal packing analysis. Plos One, 7, 2012
2RIS	Crystal structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase of candida albicans- alternate interpretation Descriptor: 3,4-dihydroxy-2-butanone 4-phosphate synthase Authors: Stenkamp, R.E, Le Trong, I. Deposit date: 2007-10-12 Release date: 2008-01-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Alternative models for two crystal structures of Candida albicans 3,4-dihydroxy-2-butanone 4-phosphate synthase. Acta Crystallogr.,Sect.D, 64, 2008
4OP2	GKRP bound to AMG-0471 and Sorbitol-6-Phosphate Descriptor: (2S)-2-{4'-[(6-aminopyridin-3-yl)sulfonyl]biphenyl-4-yl}-1,1,1-trifluoropropan-2-ol, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... Authors: Jordan, S.R, Chmait, S. Deposit date: 2014-02-04 Release date: 2014-07-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis. J.Med.Chem., 58, 2015
3UU3	The GLIC pentameric Ligand-Gated Ion Channel Loop2-20' oxidized mutant in a locally-closed conformation (LC1 subtype) Descriptor: DODECYL-BETA-D-MALTOSIDE, Glr4197 protein Authors: Sauguet, L, Nury, H, Corringer, P.J, Delarue, M. Deposit date: 2011-11-28 Release date: 2012-05-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.15 Å) Cite: A locally closed conformation of a bacterial pentameric proton-gated ion channel. Nat.Struct.Mol.Biol., 19, 2012

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