PDB: 302 resultsInfo pagesStatus searchChemie searchBIRD

---

6G0A	The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution. Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*TP*AP*AP*CP*CP*GP*CP*GP*TP*TP*DC)-3'), ... Authors: Parkash, V, Johansson, E. Deposit date: 2018-03-16 Release date: 2019-01-30 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.62 Å) Cite: Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon. Nat Commun, 10, 2019
8B79	The crystal structure of M644G variant of DNA Pol Epsilon containing UTP in the polymerase active site Descriptor: ACETATE ION, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-29 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.65 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
2DY4	Crystal structure of RB69 GP43 in complex with DNA containing Thymine Glycol Descriptor: 5'-D(*CP*GP*(CTG)P*GP*GP*AP*AP*TP*GP*A*CP*AP*GP*CP*CP*GP*CP*G)-3', 5'-D(*GP*CP*GP*GP*CP*TP*GP*T*CP*AP*TP*TP*CP*CP*A)-3', DNA polymerase Authors: Aller, P, Rould, M.A, Hogg, M, Wallace, S.S, Doublie, S. Deposit date: 2006-09-06 Release date: 2007-01-09 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.65 Å) Cite: A structural rationale for stalling of a replicative DNA polymerase at the most common oxidative thymine lesion, thymine glycol. Proc.Natl.Acad.Sci.USA, 104, 2007
3RMB	Crystal Structure of a replicative DNA polymerase bound to DNA containing Thymine Glycol Descriptor: DNA (5'-D(*CP*GP*CP*(CTG)P*GP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*CP*A)-3'), DNA polymerase, ... Authors: Aller, P, Duclos, S, Wallace, S.S, Doublie, S. Deposit date: 2011-04-20 Release date: 2011-08-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.65 Å) Cite: A crystallographic study of the role of sequence context in thymine glycol bypass by a replicative DNA polymerase serendipitously sheds light on the exonuclease complex. J.Mol.Biol., 412, 2011
6I8A	The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution. Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... Authors: Parkash, V, Johansson, E. Deposit date: 2018-11-19 Release date: 2019-01-30 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.652 Å) Cite: Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon. Nat Commun, 10, 2019
3KD1	Closed binary complex of an RB69 gp43 fingers domain mutant complexed with an acyclic GMP terminated primer template pair. Descriptor: DNA (5'-D(*CP*GP*TP*CP*TP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*AP*(4DG))-3'), DNA polymerase, ... Authors: Zahn, K.E, Doublie, S. Deposit date: 2009-10-22 Release date: 2011-04-13 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.66 Å) Cite: Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase. J.Biol.Chem., 286, 2011
4B08	Yeast DNA polymerase alpha, Selenomethionine protein Descriptor: DNA POLYMERASE ALPHA CATALYTIC SUBUNIT A Authors: Perera, R.L, Torella, R, Klinge, S, Kilkenny, M.L, Maman, J.D, Pellegrini, L. Deposit date: 2012-06-29 Release date: 2013-02-27 Last modified: 2013-05-01 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Mechanism for Priming DNA Synthesis by Yeast DNA Polymerase Alpha Elife, 2, 2013
3A2F	Crystal Structure of Pyrococcus furiosus DNA polymerase/PCNA monomer mutant complex Descriptor: DNA polymerase, DNA polymerase sliding clamp Authors: Nishida, H, Ishino, Y, Morikawa, K. Deposit date: 2009-05-15 Release date: 2009-11-03 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Structural determinant for switching between the polymerase and exonuclease modes in the PCNA-replicative DNA polymerase complex To be Published
2GV9	Crystal structure of the Herpes Simplex virus type 1 DNA polymerase Descriptor: DNA polymerase, GUANIDINE, MERCURY (II) ION, ... Authors: Liu, S. Deposit date: 2006-05-02 Release date: 2006-05-16 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.68 Å) Cite: Crystal structure of the herpes simplex virus 1 DNA polymerase. J.Biol.Chem., 281, 2006
1Q9X	Crystal structure of Enterobacteria phage RB69 gp43 DNA polymerase complexed with tetrahydrofuran containing DNA Descriptor: 1',2'-DIDEOXYRIBOFURANOSE-5'-PHOSPHATE, 2',3'-DIDEOXYCYTIDINE-5'-MONOPHOSPHATE, 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ... Authors: Freisinger, E, Grollman, A.P, Miller, H, Kisker, C. Deposit date: 2003-08-26 Release date: 2004-04-27 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Lesion (in)tolerance reveals insights into DNA replication fidelity. Embo J., 23, 2004
3KD5	Closed ternary complex of an RB69 gp43 fingers domain mutant complexed with an acyclic GMP terminated primer template pair and phosphonoformic acid. Descriptor: DNA (5'-D(*CP*GP*TP*CP*TP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*AP*(4DG))-3'), DNA polymerase, ... Authors: Zahn, K.E, Doublie, S. Deposit date: 2009-10-22 Release date: 2011-04-13 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase. J.Biol.Chem., 286, 2011
8WPE	Structure of monkeypox virus polymerase complex F8-A22-E4-H5 (tag-free A22) with exogenous DNA Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, A22R DNA polymerase processivity factor, DNA polymerase, ... Authors: Wang, X, Li, N, Gao, N. Deposit date: 2023-10-10 Release date: 2023-11-29 Last modified: 2023-12-27 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5. Mol.Cell, 83, 2023
8WPK	Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with exgenous DNA Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA polymerase, DNA polymerase processivity factor, ... Authors: Wang, X, Li, N, Gao, N. Deposit date: 2023-10-10 Release date: 2023-11-29 Last modified: 2023-12-27 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5. Mol.Cell, 83, 2023
8B77	The crystal structure of N828V variant of DNA Pol Epsilon containing dATP in the polymerase active site Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-29 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
1CLQ	CRYSTAL STRUCTURE OF A REPLICATION FORK DNA POLYMERASE EDITING COMPLEX AT 2.7 A RESOLUTION Descriptor: CALCIUM ION, DNA (5'-D(*AP*GP*TP*AP*GP*TP*TP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*AP*AP*CP*TP*AP*CP*T)-3'), ... Authors: Shamoo, Y, Steitz, T.A. Deposit date: 1999-04-30 Release date: 1999-10-28 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Building a replisome from interacting pieces: sliding clamp complexed to a peptide from DNA polymerase and a polymerase editing complex. Cell(Cambridge,Mass.), 99, 1999
3K5L	Crystal structure of E.coli Pol II-abasic DNA-dATP Lt(0, 3) ternary complex Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*GP*TP*GP*CP*CP*TP*AP*GP*CP*GP*TP*AP*(DOC))-3'), DNA (5'-D(*TP*AP*TP*(3DR)P*GP*TP*AP*CP*GP*CP*TP*AP*GP*GP*CP*AP*CP*A)-3'), ... Authors: Yang, W, Wang, F. Deposit date: 2009-10-07 Release date: 2010-02-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural insight into translesion synthesis by DNA Pol II. Cell(Cambridge,Mass.), 139, 2009
6H1V	The crystal structure of Pol2CORE in complex with DNA and an incoming nucleotide, carrying an Fe-S cluster Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(P*AP*AP*TP*TP*GP*AP*AP*CP*GP*CP*GP*GP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*CP*CP*GP*CP*GP*TP*TP*(DOC))-3'), ... Authors: Parkash, V, Johansson, E. Deposit date: 2018-07-12 Release date: 2019-04-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural evidence for an essential Fe-S cluster in the catalytic core domain of DNA polymerase ε. Nucleic Acids Res., 47, 2019
4FLV	Pyrococcus abyssi B family DNA polymerase bound to a dsDNA, in edition mode Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA polymerase 1, GLYCEROL, ... Authors: Gouge, J, Delarue, M. Deposit date: 2012-06-15 Release date: 2012-08-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Molecular Recognition of Canonical and Deaminated Bases by P. abyssi Family B DNA Polymerase. J.Mol.Biol., 423, 2012
7RSS	Kod-RI incorporating DNA, n+2 Descriptor: DNA polymerase, Primer, Template Authors: Hajjar, M, Chim, N, Chaput, J.C. Deposit date: 2021-08-11 Release date: 2022-08-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid. Nucleic Acids Res., 50, 2022
3TAE	5-hydroxycytosine paired with dAMP in RB69 gp43 Descriptor: DNA (5'-D(*CP*CP*(5OC)P*GP*GP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*CP*CP*A)-3'), DNA polymerase, ... Authors: Zahn, K.E. Deposit date: 2011-08-04 Release date: 2011-11-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.71 Å) Cite: The miscoding potential of 5-hydroxycytosine arises due to template instability in the replicative polymerase active site. Biochemistry, 50, 2011
5VU7	TNA polymerase, open ternary complex Descriptor: 5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXYTETRAHYDROFURAN-3-YL DIHYDROGEN PHOSPHATE, DNA polymerase, DNA template, ... Authors: Chim, N, Chaput, J.C. Deposit date: 2017-05-18 Release date: 2017-12-06 Last modified: 2017-12-13 Method: X-RAY DIFFRACTION (2.72 Å) Cite: Structural basis for TNA synthesis by an engineered TNA polymerase. Nat Commun, 8, 2017
2XHB	Crystal structure of DNA polymerase from Thermococcus gorgonarius in complex with hypoxanthine-containing DNA Descriptor: 5'-D(*AP*AP*AP*AP*AP*AP*AP*AP*A)-3', DNA POLYMERASE, HYPOXANTHINE-CONTAINING DNA, ... Authors: Killelea, T, Ghosh, S, Tan, S.S, Heslop, P, Firbank, S.J, Kool, E.T, Connolly, B.A. Deposit date: 2010-06-14 Release date: 2010-07-21 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.72 Å) Cite: Probing the Interaction of Archaeal DNA Polymerases with Deaminated Bases Using X-Ray Crystallography and Non-Hydrogen Bonding Isosteric Base Analogues. Biochemistry, 49, 2010
5N2E	Structure of the E9 DNA polymerase from vaccinia virus Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Tarbouriech, N, Burmeister, W.P, Iseni, F. Deposit date: 2017-02-07 Release date: 2017-11-29 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.74 Å) Cite: The vaccinia virus DNA polymerase structure provides insights into the mode of processivity factor binding. Nat Commun, 8, 2017
1WN7	Crystal structure of archaeal family B DNA polymerase mutant Descriptor: Family B DNA Polymerase, GLYCEROL, NICKEL (II) ION Authors: Kuroita, T, Matsumura, H, Yokota, N, Hashimoto, H, Imanaka, T, Inoue, T, Kai, Y. Deposit date: 2004-07-28 Release date: 2005-08-02 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Structural Mechanism for Coordination of Proofreading and Polymerase Activities in Archaeal DNA Polymerases J.Mol.Biol., 351, 2005
2OZS	Crystal structure of RB69 gp43 in complex with DNA with dATP opposite dTMP Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA polymerase, MAGNESIUM ION, ... Authors: Zahn, K.E, Belrhali, H, Wallace, S.S, Doublie, S. Deposit date: 2007-02-27 Release date: 2007-10-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Caught bending the a-rule: crystal structures of translesion DNA synthesis with a non-natural nucleotide. Biochemistry, 46, 2007

<12345678910111213>