PDB: 1867 resultsInfo pagesStatus searchChemie searchBIRD

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8CZI	Cryo-EM structure of the SARS-CoV-2 HR1HR2 fusion core complex with extended HR2 Descriptor: Scaffolded Spike protein S2' HR1, Spike protein S2' HR2 Authors: Yang, K, Brunger, A.T. Deposit date: 2022-05-24 Release date: 2022-09-07 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (2.22 Å) Cite: Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein. Proc.Natl.Acad.Sci.USA, 119, 2022
8DLQ	Cryo-EM structure of SARS-CoV-2 Gamma (P.1) spike protein in complex with human ACE2 (focused refinement of RBD and ACE2) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein Authors: Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Zhou, S, Tuttle, K.S, Subramaniam, S. Deposit date: 2022-07-08 Release date: 2022-08-31 Method: ELECTRON MICROSCOPY (2.77 Å) Cite: SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization. Nat Commun, 13, 2022
8DAO	Crystal structure of SARS-CoV-2 spike stem fusion peptide in complex with neutralizing antibody COV44-79 Descriptor: COV44-79 heavy chain constant domain, COV44-79 heavy chain variable domain, COV44-79 light chain constant domain, ... Authors: Lin, T.H, Lee, C.C.D, Yuan, M, Wilson, I.A. Deposit date: 2022-06-13 Release date: 2022-07-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Broadly neutralizing antibodies target the coronavirus fusion peptide. Science, 377, 2022
8DF5	SARS-CoV-2 Beta RBD in complex with human ACE2 and S304 Fab and S309 Fab Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: McCallum, M, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G, Veesler, D. Deposit date: 2022-06-21 Release date: 2022-08-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution. Science, 377, 2022
8DM6	Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with human ACE2 (focused refinement of RBD and ACE2) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein Authors: Zhu, X, Saville, J.W, Mannar, D, Berezuk, A.M, Cholak, S, Tuttle, K.S, Vahdatihassani, F, Subramaniam, S. Deposit date: 2022-07-08 Release date: 2023-02-08 Method: ELECTRON MICROSCOPY (2.77 Å) Cite: Structural analysis of receptor engagement and antigenic drift within the BA.2 spike protein. Cell Rep, 42, 2023
8DM7	Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with mouse ACE2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Zhu, X, Saville, J.W, Mannar, D, Berezuk, A.M, Cholak, S, Tuttle, K.S, Vahdatihassani, F, Subramaniam, S. Deposit date: 2022-07-08 Release date: 2023-02-08 Method: ELECTRON MICROSCOPY (2.49 Å) Cite: Structural analysis of receptor engagement and antigenic drift within the BA.2 spike protein. Cell Rep, 42, 2023
8DM8	Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with mouse ACE2 (focused refinement of RBD and ACE2) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein Authors: Zhu, X, Saville, J.W, Mannar, D, Berezuk, A.M, Cholak, S, Tuttle, K.S, Vahdatihassani, F, Subramaniam, S. Deposit date: 2022-07-08 Release date: 2023-02-08 Method: ELECTRON MICROSCOPY (2.68 Å) Cite: Structural analysis of receptor engagement and antigenic drift within the BA.2 spike protein. Cell Rep, 42, 2023
8DM5	Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with human ACE2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... Authors: Zhu, X, Saville, J.W, Mannar, D, Berezuk, A.M, Cholak, S, Tuttle, K.S, Vahdatihassani, F, Subramaniam, S. Deposit date: 2022-07-08 Release date: 2023-02-08 Method: ELECTRON MICROSCOPY (2.51 Å) Cite: Structural analysis of receptor engagement and antigenic drift within the BA.2 spike protein. Cell Rep, 42, 2023
8EDF	Bovine Fab SKD in complex with Sars COV-2 receptor binding domain Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, SKD Fab Light chain, SKD Fab heavy chain, ... Authors: Stanfield, R.L, Wilson, I.A. Deposit date: 2022-09-04 Release date: 2023-09-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.4 Å) Cite: The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
8ELH	Crystal Structure of HLA-B*15:01 in complex with spike derived peptide NQKLIANQF from SARS-CoV-2 virus Descriptor: ACETATE ION, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ... Authors: Murdolo, L.D, Gras, S. Deposit date: 2022-09-24 Release date: 2023-06-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.85 Å) Cite: A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection. Nature, 620, 2023
8DV1	SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to linker variant of affinity matured ACE2 mimetic CVD432 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2,Immunoglobulin gamma-1 heavy chain fusion,Immunoglobulin gamma-1 heavy chain, Spike glycoprotein Authors: QCRG Structural Biology Consortium, Remesh, S.G, Merz, G.E, Brilot, A.F, Chio, U, Verba, K.A. Deposit date: 2022-07-27 Release date: 2022-08-31 Last modified: 2023-03-15 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps. Structure, 31, 2023
8DV2	SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to computationally engineered ACE2 mimetic CVD293 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2,Immunoglobulin gamma-1 heavy chain fusion, Spike glycoprotein Authors: QCRG Structural Biology Consortium, Remesh, S.G, Merz, G.E, Brilot, A.F, Chio, U, Verba, K.A. Deposit date: 2022-07-27 Release date: 2022-08-31 Last modified: 2023-03-15 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps. Structure, 31, 2023
8FA1	Cryo-EM structure of the SARS-CoV-2 HR1HR2 fusion core complex with N969K mutation Descriptor: Ferritin, Dps family protein and Spike protein S2' chimera, Spike protein S2' HR2 Authors: Yang, K, Brunger, A.T. Deposit date: 2022-11-25 Release date: 2023-03-29 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.51 Å) Cite: Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor. Proc.Natl.Acad.Sci.USA, 120, 2023
7FJN	Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with two T6 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Envelope glycoprotein, T6 heavy chain, ... Authors: Wang, X, Zhang, L, Zhang, S, Liang, Q. Deposit date: 2021-08-04 Release date: 2022-04-27 Method: ELECTRON MICROSCOPY (3.25 Å) Cite: RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants. Iscience, 25, 2022
7FC5	Crystal structure of SARS-CoV-2 RBD and horse ACE2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, Spike protein S1 Authors: Wang, X.Q, Lan, J, Ge, J.W. Deposit date: 2021-07-13 Release date: 2022-06-22 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.894 Å) Cite: Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2. Structure, 30, 2022
7F5R	Crystal structure of SARS-CoV-2 Y453F-RBD bound to mink ACE2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, ... Authors: Wang, X.Q, Ding, Q, Lan, J, Ren, W.L. Deposit date: 2021-06-22 Release date: 2022-06-22 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.01 Å) Cite: Crystal structure of SARS-CoV-2 Y453F-RBD bound to mink ACE2 To Be Published
7JJC	Crystal structure of neuropilin-1 b1 domain in complex with SARS-CoV-2 S1 C-end rule (CendR) peptide Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Neuropilin-1, ... Authors: Chen, K.-E, Collins, B.M. Deposit date: 2020-07-25 Release date: 2020-10-28 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.36 Å) Cite: Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science, 370, 2020
7KNE	Cryo-EM structure of single ACE2-bound SARS-CoV-2 trimer spike at pH 5.5 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L. Deposit date: 2020-11-04 Release date: 2020-12-16 Last modified: 2021-12-15 Method: ELECTRON MICROSCOPY (3.85 Å) Cite: Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
7KNI	Cryo-EM structure of Triple ACE2-bound SARS-CoV-2 Trimer Spike at pH 5.5 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L. Deposit date: 2020-11-04 Release date: 2020-12-16 Last modified: 2021-12-15 Method: ELECTRON MICROSCOPY (3.91 Å) Cite: Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
7KNB	Cryo-EM structure of single ACE2-bound SARS-CoV-2 trimer spike at pH 7.4 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Gorman, J, Kwong, P.D, Shapiro, L. Deposit date: 2020-11-04 Release date: 2020-12-09 Last modified: 2021-12-15 Method: ELECTRON MICROSCOPY (3.93 Å) Cite: Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
7KJ3	SARS-CoV-2 Spike Glycoprotein with two ACE2 Bound Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Zhang, J, Xiao, T.S, Cai, Y.F, Chen, B. Deposit date: 2020-10-25 Release date: 2020-11-11 Last modified: 2021-02-24 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent. Nat.Struct.Mol.Biol., 28, 2021
7KMB	ACE2-RBD Focused Refinement Using Symmetry Expansion of Applied C3 for Triple ACE2-bound SARS-CoV-2 Trimer Spike at pH 7.4 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Gorman, J, Kwong, P.D, Shapiro, L. Deposit date: 2020-11-02 Release date: 2020-12-09 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.39 Å) Cite: Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
7KNH	Cryo-EM Structure of Double ACE2-Bound SARS-CoV-2 Trimer Spike at pH 5.5 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L. Deposit date: 2020-11-04 Release date: 2020-12-16 Last modified: 2021-12-15 Method: ELECTRON MICROSCOPY (3.74 Å) Cite: Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
7KJ2	SARS-CoV-2 Spike Glycoprotein with one ACE2 Bound Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Zhang, J, Xiao, T.S, Cai, Y.F, Chen, B. Deposit date: 2020-10-25 Release date: 2020-11-11 Last modified: 2021-02-24 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent. Nat.Struct.Mol.Biol., 28, 2021
7KMS	Cryo-EM structure of triple ACE2-bound SARS-CoV-2 trimer spike at pH 7.4 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Gorman, J, Kwong, P.D, Shapiro, L. Deposit date: 2020-11-03 Release date: 2020-12-09 Last modified: 2021-12-15 Method: ELECTRON MICROSCOPY (3.64 Å) Cite: Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020

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