8DV1

SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to linker variant of affinity matured ACE2 mimetic CVD432

Summary for 8DV1

• Entry DOI: 10.2210/pdb8dv1/pdb
• EMDB information: 27730
• Descriptor: Spike glycoprotein, Angiotensin-converting enzyme 2,Immunoglobulin gamma-1 heavy chain fusion,Immunoglobulin gamma-1 heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: sars-cov-2, spike, receptor-binding domain, ace2 receptor traps, antiviral protein, viral protein-antiviral protein complex, viral protein/antiviral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 2
• Total formula weight: 245833.41

Authors

QCRG Structural Biology Consortium,Remesh, S.G.,Merz, G.E.,Brilot, A.F.,Chio, U.,Verba, K.A. (deposition date: 2022-07-27, release date: 2022-08-31, Last modification date: 2023-03-15)

• Primary citation: Remesh, S.G.,Merz, G.E.,Brilot, A.F.,Chio, U.S.,Rizo, A.N.,Pospiech Jr., T.H.,Lui, I.,Laurie, M.T.,Glasgow, J.,Le, C.Q.,Zhang, Y.,Diwanji, D.,Hernandez, E.,Lopez, J.,Mehmood, H.,Pawar, K.I.,Pourmal, S.,Smith, A.M.,Zhou, F.,DeRisi, J.,Kortemme, T.,Rosenberg, O.S.,Glasgow, A.,Leung, K.K.,Wells, J.A.,Verba, K.A.; Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps.; Structure, 31:253-, 2023; PubMed: 36805129; DOI: 10.1016/j.str.2023.01.009

Experimental method

ELECTRON MICROSCOPY (3.4 Å)