8DV1
SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to linker variant of affinity matured ACE2 mimetic CVD432
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Spike glycoprotein | polymer | 1208 | 133753.3 | 1 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB | Severe acute respiratory syndrome coronavirus 2 | S glycoprotein,E2,Peplomer protein |
2 | D | Angiotensin-converting enzyme 2,Immunoglobulin gamma-1 heavy chain fusion,Immunoglobulin gamma-1 heavy chain | polymer | 967 | 110531.7 | 1 | UniProt (Q9BYF1) UniProt (P0DOX5) Pfam (PF01401) Pfam (PF16959) Pfam (PF07654) In PDB | Homo sapiens (human) | Angiotensin-converting enzyme homolog,ACEH,Angiotensin-converting enzyme-related carboxypeptidase,ACE-related carboxypeptidase,Metalloprotease MPROT15,Immunoglobulin gamma-1 heavy chain NIE |
3 | A, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) |
Sequence modifications
A: 1 - 1208 (UniProt: P0DTC2)
D: 18 - 740 (UniProt: Q9BYF1)
D: 753 - 984 (UniProt: P0DOX5)
PDB | External Database | Details |
---|---|---|
Gly 682 | Arg 682 | engineered mutation |
Ser 683 | Arg 683 | engineered mutation |
Ser 685 | Arg 685 | engineered mutation |
Pro 986 | Lys 986 | engineered mutation |
Pro 987 | Val 987 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Phe 31 | Lys 31 | engineered mutation |
Asp 33 | Asn 33 | engineered mutation |
Ser 34 | His 34 | engineered mutation |
Gln 35 | Glu 35 | engineered mutation |
Gly 741 | - | linker |
Ser 742 | - | linker |
Ser 743 | - | linker |
Gly 744 | - | linker |
Gly 745 | - | linker |
Gly 746 | - | linker |
Gly 747 | - | linker |
Ser 748 | - | linker |
Gly 749 | - | linker |
Gly 750 | - | linker |
Gly 751 | - | linker |
Gly 752 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 244285.0 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1548.5 | |
All* | Total formula weight | 245833.4 |