PDB: 160395 resultsInfo pagesStatus searchChemie searchBIRD

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2R9L	Polymerase Domain from Mycobacterium tuberculosis Ligase D in complex with DNA Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*DGP*DCP*DCP*DGP*DCP*DAP*DAP*DCP*DGP*DCP*DA)-3'), ... Authors: Brissett, N.C, Fox, G.C, Pitcher, R.S, Doherty, A.J. Deposit date: 2007-09-13 Release date: 2008-01-08 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure of a NHEJ polymerase-mediated DNA synaptic complex Science, 318, 2007
6UJC	Integrin alpha-v beta-8 in complex with the Fabs C6-RGD3 and 11D12v2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C6-RGD3 heavy chain Fab, ... Authors: Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L. Deposit date: 2019-10-02 Release date: 2020-02-05 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (3.56 Å) Cite: Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta. Cell, 180, 2020
7TAS	SARS-CoV-2 spike in complex with the S2K146 neutralizing antibody Fab fragment (local refinement of the RBD and S2K146) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, S2K146 Fab heavy chain, S2K146 Fab light chain, ... Authors: Park, Y.J, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2021-12-21 Release date: 2022-01-12 Last modified: 2022-02-09 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry. Science, 375, 2022
7TAT	SARS-CoV-2 spike in complex with the S2K146 neutralizing antibody Fab fragment (two receptor-binding domains open) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S2K146 Fab heavy chain, ... Authors: Park, Y.J, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. Deposit date: 2021-12-21 Release date: 2022-01-12 Last modified: 2022-02-09 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry. Science, 375, 2022
5ER7	Connexin-26 Bound to Calcium Descriptor: CALCIUM ION, Gap junction beta-2 protein Authors: Purdy, M.D, Bennett, B.C, Baker, K.A, Yeager, M.J. Deposit date: 2015-11-13 Release date: 2016-01-27 Last modified: 2019-12-04 Method: X-RAY DIFFRACTION (3.286 Å) Cite: An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels. Nat Commun, 7, 2016
5DAH	Crystal structure of PZP domain of human AF10 protein fused with Histone H3 peptide Descriptor: Histone H3 peptide, Protein AF-10, SULFATE ION, ... Authors: Chen, S, Patel, D.J. Deposit date: 2015-08-19 Release date: 2015-10-21 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.611 Å) Cite: The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79. Mol.Cell, 60, 2015
6MTH	E. coli DHFR complex modeled with three ligand states Descriptor: (6S)-5,6,7,8-TETRAHYDROFOLATE, CHLORIDE ION, DIHYDROFOLIC ACID, ... Authors: Cao, H, Rodrigues, J, Benach, J, Frommelt, A, Morisco, L, Koss, J, Shakhnovich, E, Skolnick, J. Deposit date: 2018-10-19 Release date: 2019-05-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Time-resolved x-ray crystallography capture of a slow reaction tetrahydrofolate intermediate. Struct Dyn., 6, 2019
8GUW	Structure of Aurora Kinase A in complex with activator peptide Descriptor: ADENOSINE-5'-DIPHOSPHATE, Peptide from Centrosomal protein of 192 kDa,Aurora kinase A Authors: Lee, I.-G, Park, J. Deposit date: 2022-09-13 Release date: 2023-05-31 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural basis for CEP192-mediated regulation of centrosomal AURKA. Sci Adv, 9, 2023
7V04	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxamide Descriptor: 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxamide, MANGANESE (II) ION, Polymerase acidic protein Authors: Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. Deposit date: 2022-05-09 Release date: 2022-12-21 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
8FIE	Crystal Structure of Erwinia tracheiphila CYP114 mutant - A261D Descriptor: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE Authors: Stewart Jr, C.E, Alexander, L.E, Nagel, R. Deposit date: 2022-12-16 Release date: 2023-07-05 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Dual factors required for cytochrome-P450-mediated hydrocarbon ring contraction in bacterial gibberellin phytohormone biosynthesis. Proc.Natl.Acad.Sci.USA, 120, 2023
8FIC	Crystal Structure of Erwinia tracheiphila CYP114 in complex with ent-kaurenoic acid (Crystal Form 1) Descriptor: (8alpha,9beta,10alpha,13alpha)-kaur-16-en-18-oic acid, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE Authors: Stewart Jr, C.E, Nagel, R. Deposit date: 2022-12-16 Release date: 2023-07-05 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Dual factors required for cytochrome-P450-mediated hydrocarbon ring contraction in bacterial gibberellin phytohormone biosynthesis. Proc.Natl.Acad.Sci.USA, 120, 2023
6MT8	E. coli DHFR complex modeled with two ligand states Descriptor: (6S)-5,6,7,8-TETRAHYDROFOLATE, CHLORIDE ION, DIHYDROFOLIC ACID, ... Authors: Cao, H, Rodrigues, J, Benach, J, Frommelt, A, Morisco, L, Koss, J, Shakhnovich, E, Skolnick, J. Deposit date: 2018-10-19 Release date: 2019-05-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Time-resolved x-ray crystallography capture of a slow reaction tetrahydrofolate intermediate. Struct Dyn., 6, 2019
5CG9	NgTET1 in complex with 5mC DNA in space group P3221 Descriptor: 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, DNA (5'-D(*TP*GP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*G)-3'), ... Authors: Hashimoto, H, Pais, J.E, Dai, N, Zhang, X, Zheng, Y, Cheng, X. Deposit date: 2015-07-09 Release date: 2015-09-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.693 Å) Cite: Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA. Nucleic Acids Res., 43, 2015
6UJB	Integrin alpha-v beta-8 in complex with the Fabs C6D4 and 11D12v2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C6D4 heavy chain Fab, ... Authors: Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L. Deposit date: 2019-10-02 Release date: 2020-02-05 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (3.51 Å) Cite: Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta. Cell, 180, 2020
8FID	Crystal Structure of Erwinia tracheiphila CYP114 in complex with ent-kaurenoic acid (Crystal Form 2) Descriptor: (8alpha,9beta,10alpha,13alpha)-kaur-16-en-18-oic acid, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE Authors: Stewart Jr, C.E, Nagel, R. Deposit date: 2022-12-16 Release date: 2023-07-05 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Dual factors required for cytochrome-P450-mediated hydrocarbon ring contraction in bacterial gibberellin phytohormone biosynthesis. Proc.Natl.Acad.Sci.USA, 120, 2023
8FIB	Crystal Structure of Erwinia tracheiphila CYP114 Descriptor: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE Authors: Stewart Jr, C.E, Nagel, R. Deposit date: 2022-12-16 Release date: 2023-07-05 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Dual factors required for cytochrome-P450-mediated hydrocarbon ring contraction in bacterial gibberellin phytohormone biosynthesis. Proc.Natl.Acad.Sci.USA, 120, 2023
5CG8	NgTET1 in complex with 5hmC DNA Descriptor: 2-OXOGLUTARIC ACID, DNA (5'-D(*AP*GP*AP*AP*TP*TP*CP*CP*GP*TP*TP*CP*CP*A)-3'), DNA (5'-D(*TP*GP*GP*AP*AP*(5HC)P*GP*GP*AP*AP*TP*TP*CP*T)-3'), ... Authors: Hashimoto, H, Pais, J.E, Dai, N, Zhang, X, Zheng, Y, Cheng, X. Deposit date: 2015-07-09 Release date: 2015-09-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.702 Å) Cite: Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA. Nucleic Acids Res., 43, 2015
7DCF	Crystal structure of EHMT2 SET domain in complex with compound 10 Descriptor: 5'-methoxy-6'-(1-methyl-2,3,4,7-tetrahydroazepin-5-yl)spiro[cyclobutane-1,3'-indole]-2'-amine, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYLMETHIONINE, ... Authors: Suzuki, M, Katayama, K. Deposit date: 2020-10-26 Release date: 2021-02-10 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating beta-Thalassemia and Sickle Cell Disease. Acs Med.Chem.Lett., 12, 2021
6CPN	Crystal structure of DR11 presenting the RQ13 peptide Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gag polyprotein, ... Authors: Farenc, C, Gras, S, Rossjohn, J. Deposit date: 2018-03-13 Release date: 2018-06-06 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2 Å) Cite: CD4+T cell-mediated HLA class II cross-restriction in HIV controllers. Sci Immunol, 3, 2018
6CQN	Crystal structure of F5 TCR -DR11-RQ13 peptide complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, F5 alpha chain, ... Authors: Farenc, C, Gras, S, Rossjohn, J. Deposit date: 2018-03-15 Release date: 2018-06-06 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.5 Å) Cite: CD4+T cell-mediated HLA class II cross-restriction in HIV controllers. Sci Immunol, 3, 2018
7UNF	CryoEM structure of a mEAK7 bound human V-ATPase complex Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ... Authors: Wang, R, Li, X. Deposit date: 2022-04-10 Release date: 2022-06-15 Last modified: 2022-06-29 Method: ELECTRON MICROSCOPY (4.08 Å) Cite: Molecular basis of mEAK7-mediated human V-ATPase regulation. Nat Commun, 13, 2022
5ERA	Human Connexin-26 (Calcium-free) Descriptor: Gap junction beta-2 protein Authors: Purdy, M.D, Bennett, B.C, Baker, K.A, Yeager, M.J. Deposit date: 2015-11-13 Release date: 2016-01-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.8 Å) Cite: An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels. Nat Commun, 7, 2016
6CQL	Crystal structure of F24 TCR -DR11-RQ13 peptide complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, F24 alpha chain, F24 beta Chain, ... Authors: Farenc, C, Gras, S, Rossjohn, J. Deposit date: 2018-03-15 Release date: 2018-06-06 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.4 Å) Cite: CD4+T cell-mediated HLA class II cross-restriction in HIV controllers. Sci Immunol, 3, 2018
6CQQ	Crystal structure of F24 TCR -DR15-RQ13 peptide complex Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, F24 alpha chain, ... Authors: Farenc, C, Gras, S, Rossjohn, J. Deposit date: 2018-03-16 Release date: 2018-06-06 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.8 Å) Cite: CD4+T cell-mediated HLA class II cross-restriction in HIV controllers. Sci Immunol, 3, 2018
8DS8	Crystal structure of human TNRC18 BAH domain in complex with H3K9me3 peptide Descriptor: Histone H3.1, Trinucleotide repeat-containing gene 18 protein Authors: Song, J.K, Lu, J.W. Deposit date: 2022-07-21 Release date: 2023-08-02 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.84 Å) Cite: TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons. Nature, 623, 2023

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