8E2Q
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![BU of 8e2q by Molmil](/molmil-images/mine/8e2q) | Crystal structure of TadAC-1.17 in a complex with ssDNA | Descriptor: | DNA (5'-D(P*GP*CP*GP*GP*CP*TP*(D8A)P*CP*GP*GP*A)-3'), GLYCEROL, ZINC ION, ... | Authors: | Feliciano, P.R, Lee, S.J, Ciaramella, G. | Deposit date: | 2022-08-15 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Improved cytosine base editors generated from TadA variants. Nat.Biotechnol., 41, 2023
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8DWT
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![BU of 8dwt by Molmil](/molmil-images/mine/8dwt) | SPOP W22R Form 2 | Descriptor: | Speckle-type POZ protein | Authors: | Cuneo, M.J, Mittag, T, O'Flynn, B, Lo, Y.H. | Deposit date: | 2022-08-02 | Release date: | 2023-01-18 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (6.2 Å) | Cite: | Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation. Mol.Cell, 83, 2023
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6Z6U
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![BU of 6z6u by Molmil](/molmil-images/mine/6z6u) | 1.25 A structure of human apoferritin obtained from Titan Mono-BCOR microscope | Descriptor: | Ferritin heavy chain, MAGNESIUM ION, SODIUM ION | Authors: | Yip, K.M, Fischer, N, Paknia, E, Chari, A, Stark, H. | Deposit date: | 2020-05-29 | Release date: | 2020-06-24 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (1.25 Å) | Cite: | Atomic-resolution protein structure determination by cryo-EM. Nature, 587, 2020
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8DWV
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![BU of 8dwv by Molmil](/molmil-images/mine/8dwv) | Full-length wild type SPOP | Descriptor: | Speckle-type POZ protein | Authors: | Cuneo, M.J, Mittag, T, O'Flynn, B, Lo, Y.H. | Deposit date: | 2022-08-02 | Release date: | 2023-01-18 | Last modified: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation. Mol.Cell, 83, 2023
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7P2P
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![BU of 7p2p by Molmil](/molmil-images/mine/7p2p) | Human Signal Peptidase Complex Paralog A (SPC-A) | Descriptor: | Signal peptidase complex catalytic subunit SEC11A, Signal peptidase complex subunit 1, Signal peptidase complex subunit 2, ... | Authors: | Liaci, A.M, Foerster, F. | Deposit date: | 2021-07-06 | Release date: | 2021-10-06 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage. Mol.Cell, 81, 2021
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8DWS
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![BU of 8dws by Molmil](/molmil-images/mine/8dws) | Full-length E47K SPOP | Descriptor: | Speckle-type POZ protein | Authors: | Cuneo, M.J, Mittag, T, O'Flynn, B, Lo, Y.H. | Deposit date: | 2022-08-02 | Release date: | 2023-01-18 | Last modified: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation. Mol.Cell, 83, 2023
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6CJ7
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![BU of 6cj7 by Molmil](/molmil-images/mine/6cj7) | Crystal structure of Manduca sexta Serine protease inhibitor (Serpin)-12 | Descriptor: | Serpin-12 | Authors: | Gulati, M, Hu, Y, Peng, S, Pathak, P.K, Wang, Y, Deng, J, Jiang, H. | Deposit date: | 2018-02-26 | Release date: | 2018-07-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Manduca sexta serpin-12 controls the prophenoloxidase activation system in larval hemolymph. Insect Biochem. Mol. Biol., 99, 2018
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7P2Q
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![BU of 7p2q by Molmil](/molmil-images/mine/7p2q) | Human Signal Peptidase Complex Paralog C (SPC-C) | Descriptor: | Signal peptidase complex catalytic subunit SEC11C, Signal peptidase complex subunit 1, Signal peptidase complex subunit 2, ... | Authors: | Liaci, A.M, Foerster, F. | Deposit date: | 2021-07-06 | Release date: | 2021-10-06 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage. Mol.Cell, 81, 2021
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8DWU
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![BU of 8dwu by Molmil](/molmil-images/mine/8dwu) | SPOP W22R Form 1 | Descriptor: | Speckle-type POZ protein | Authors: | Cuneo, M.J, Mittag, T, O'Flynn, B. | Deposit date: | 2022-08-02 | Release date: | 2023-01-18 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation. Mol.Cell, 83, 2023
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4R1S
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![BU of 4r1s by Molmil](/molmil-images/mine/4r1s) | Crystal structure of Petunia hydrida cinnamoyl-CoA reductase | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, cinnamoyl CoA reductase | Authors: | Noel, J.P, Louie, G.V, Bowman, M.E, Bomati, E.K. | Deposit date: | 2014-08-07 | Release date: | 2014-10-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Studies of Cinnamoyl-CoA Reductase and Cinnamyl-Alcohol Dehydrogenase, Key Enzymes of Monolignol Biosynthesis. Plant Cell, 26, 2014
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6Z23
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![BU of 6z23 by Molmil](/molmil-images/mine/6z23) | Acylenzyme complex of cefotaxime bound to deacylation mutant KPC-2 (E166Q) | Descriptor: | CEFOTAXIME, C3' cleaved, open, ... | Authors: | Tooke, C.L, Hinchliffe, P, Spencer, J. | Deposit date: | 2020-05-14 | Release date: | 2020-12-23 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance. J.Biol.Chem., 296, 2020
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7OWY
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![BU of 7owy by Molmil](/molmil-images/mine/7owy) | Crystal structure of human mitochondrial ferritin (hMTF) Fe(II)-loaded for 3 minutes showing a peroxide anion as bridging species of iron ions in the ferroxidase site | Descriptor: | CHLORIDE ION, FE (II) ION, Ferritin, ... | Authors: | Pozzi, C, Ciambellotti, S, Tassone, G, Turano, P, Mangani, S. | Deposit date: | 2021-06-21 | Release date: | 2021-10-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin. Chemistry, 27, 2021
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6Z6Y
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![BU of 6z6y by Molmil](/molmil-images/mine/6z6y) | |
5OHF
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![BU of 5ohf by Molmil](/molmil-images/mine/5ohf) | Globin sensor domain of AfGcHK (FeIII form) in complex with cyanide, partially reduced | Descriptor: | CHLORIDE ION, CYANIDE ION, Globin-coupled histidine kinase, ... | Authors: | Skalova, T, Kolenko, P, Dohnalek, J, Stranava, M, Martinkova, M. | Deposit date: | 2017-07-16 | Release date: | 2017-11-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Coordination and redox state-dependent structural changes of the heme-based oxygen sensor AfGcHK associated with intraprotein signal transduction. J. Biol. Chem., 292, 2017
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7QIU
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![BU of 7qiu by Molmil](/molmil-images/mine/7qiu) | |
6Z24
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![BU of 6z24 by Molmil](/molmil-images/mine/6z24) | |
6W2G
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![BU of 6w2g by Molmil](/molmil-images/mine/6w2g) | Crystal Structure of Y188G Variant of the Internal UBA Domain of HHR23A in Monoclinic Unit Cell | Descriptor: | 1,2-ETHANEDIOL, UV excision repair protein RAD23 homolog A | Authors: | Bowler, B.E, Zeng, B, Becht, D.C, Rothfuss, M, Sprang, S.R, Mou, T.-C. | Deposit date: | 2020-03-05 | Release date: | 2021-03-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | High-Accuracy Prediction of Stabilizing Surface Mutations to the Three-Helix Bundle, UBA(1), with EmCAST. J.Am.Chem.Soc., 145, 2023
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6Z4U
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![BU of 6z4u by Molmil](/molmil-images/mine/6z4u) | |
6W2I
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![BU of 6w2i by Molmil](/molmil-images/mine/6w2i) | Crystal Structure of Y188G Variant of the Internal UBA Domain of HHR23A | Descriptor: | GLYCEROL, UV excision repair protein RAD23 homolog A | Authors: | Bowler, B.E, Zeng, B, Becht, D.C, Rothfuss, M, Sprang, S.R, Mou, T.-C. | Deposit date: | 2020-03-05 | Release date: | 2021-03-10 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | High-Accuracy Prediction of Stabilizing Surface Mutations to the Three-Helix Bundle, UBA(1), with EmCAST. J.Am.Chem.Soc., 145, 2023
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4QQW
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![BU of 4qqw by Molmil](/molmil-images/mine/4qqw) | Crystal structure of T. fusca Cas3 | Descriptor: | CRISPR-associated helicase, Cas3 family, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), ... | Authors: | Ke, A, Huo, Y, Nam, K.H. | Deposit date: | 2014-06-30 | Release date: | 2014-08-27 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.664 Å) | Cite: | Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation. Nat.Struct.Mol.Biol., 21, 2014
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6ZHC
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![BU of 6zhc by Molmil](/molmil-images/mine/6zhc) | PROTAC6 mediated complex of VHL:EloB:EloC and Bcl-xL | Descriptor: | 1,2-ETHANEDIOL, 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]-5-[3-[4-[3-[2-[2-[2-[2-[2-[3-[[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanylidene-propoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-ynyl]phenoxy]propyl]-1,3-thiazole-4-carboxylic acid, Bcl-2-like protein 1, ... | Authors: | Chung, C. | Deposit date: | 2020-06-22 | Release date: | 2020-08-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. Acs Chem.Biol., 15, 2020
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5JY9
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![BU of 5jy9 by Molmil](/molmil-images/mine/5jy9) | |
7P06
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![BU of 7p06 by Molmil](/molmil-images/mine/7p06) | Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in outward-facing conformation with ADP-orthovanadate/ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ADP ORTHOVANADATE, MAGNESIUM ION, ... | Authors: | Szewczak-Harris, A, Wagner, M, Du, D, Schmitt, L, Luisi, B.F. | Deposit date: | 2021-06-29 | Release date: | 2021-11-10 | Method: | ELECTRON MICROSCOPY (3.77 Å) | Cite: | Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5. Nat Commun, 12, 2021
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7P05
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![BU of 7p05 by Molmil](/molmil-images/mine/7p05) | Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in inward-facing conformation with ADP/ATP and rhodamine 6G | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Pleiotropic ABC efflux transporter of multiple drugs, ... | Authors: | Szewczak-Harris, A, Wagner, M, Du, D, Schmitt, L, Luisi, B.F. | Deposit date: | 2021-06-29 | Release date: | 2021-11-10 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5. Nat Commun, 12, 2021
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7P03
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![BU of 7p03 by Molmil](/molmil-images/mine/7p03) | Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in inward-facing conformation without nucleotides | Descriptor: | Pleiotropic ABC efflux transporter of multiple drugs | Authors: | Szewczak-Harris, A, Wagner, M, Du, D, Schmitt, L, Luisi, B.F. | Deposit date: | 2021-06-29 | Release date: | 2021-11-10 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5. Nat Commun, 12, 2021
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