3AVJ
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![BU of 3avj by Molmil](/molmil-images/mine/3avj) | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | Deposit date: | 2011-03-05 | Release date: | 2012-01-18 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site. Chembiochem, 12, 2011
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3AVC
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![BU of 3avc by Molmil](/molmil-images/mine/3avc) | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | Deposit date: | 2011-03-02 | Release date: | 2012-01-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site. Chembiochem, 12, 2011
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3AVK
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![BU of 3avk by Molmil](/molmil-images/mine/3avk) | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | Deposit date: | 2011-03-05 | Release date: | 2012-01-18 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site. Chembiochem, 12, 2011
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3AO4
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![BU of 3ao4 by Molmil](/molmil-images/mine/3ao4) | Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase | Descriptor: | 3-(1,3-benzodioxol-5-yl)-1-methyl-1H-pyrazol-5-amine, CADMIUM ION, CHLORIDE ION, ... | Authors: | Wielens, J, Headey, S.J, Parker, M.W, Chalmers, D.K, Scanlon, M.J. | Deposit date: | 2010-09-20 | Release date: | 2011-03-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1 Chemmedchem, 6, 2011
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3AO3
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![BU of 3ao3 by Molmil](/molmil-images/mine/3ao3) | Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase | Descriptor: | 3-(1,3-benzodioxol-5-yl)-1-methyl-1H-pyrazole-5-carboxylic acid, CADMIUM ION, CHLORIDE ION, ... | Authors: | Wielens, J, Headey, S.J, Parker, M.W, Chalmers, D.K, Scanlon, M.J. | Deposit date: | 2010-09-20 | Release date: | 2011-03-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1 Chemmedchem, 6, 2011
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3AO5
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![BU of 3ao5 by Molmil](/molmil-images/mine/3ao5) | Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase | Descriptor: | 5-(7-bromo-1,3-benzodioxol-5-yl)-1-methyl-1H-pyrazol-3-amine, CADMIUM ION, CHLORIDE ION, ... | Authors: | Wielens, J, Headey, S.J, Parker, M.W, Chalmers, D.K, Scanlon, M.J. | Deposit date: | 2010-09-21 | Release date: | 2011-03-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1 Chemmedchem, 6, 2011
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3AO2
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![BU of 3ao2 by Molmil](/molmil-images/mine/3ao2) | Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase | Descriptor: | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 3-(7-bromo-1,3-benzodioxol-5-yl)-1-methyl-1H-pyrazol-5-amine, ... | Authors: | Wielens, J, Chalmers, D.K, Headey, S.J, Parker, M.W, Scanlon, M.J. | Deposit date: | 2010-09-20 | Release date: | 2011-03-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1 Chemmedchem, 6, 2011
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3AO1
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![BU of 3ao1 by Molmil](/molmil-images/mine/3ao1) | Fragment-based approach to the design of ligands targeting a novel site in HIV-1 integrase | Descriptor: | 1,3-benzodioxol-5-ol, CADMIUM ION, POL polyprotein, ... | Authors: | Wielens, J, Parker, M.W, Chalmers, D.K, Scanlon, M.J. | Deposit date: | 2010-09-17 | Release date: | 2011-03-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1 Chemmedchem, 6, 2011
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1B9F
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![BU of 1b9f by Molmil](/molmil-images/mine/1b9f) | MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY | Descriptor: | CACODYLATE ION, PROTEIN (INTEGRASE), SULFATE ION | Authors: | Greenwald, J, Le, V, Butler, S.L, Bushman, F.D, Choe, S. | Deposit date: | 1999-02-11 | Release date: | 1999-07-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity. Biochemistry, 38, 1999
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1B92
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![BU of 1b92 by Molmil](/molmil-images/mine/1b92) | MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY | Descriptor: | CACODYLATE ION, PROTEIN (INTEGRASE), SULFATE ION | Authors: | Greenwald, J, Le, V, Butler, S.L, Bushman, F.D, Choe, S. | Deposit date: | 1999-02-19 | Release date: | 1999-07-19 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity. Biochemistry, 38, 1999
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1B9D
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![BU of 1b9d by Molmil](/molmil-images/mine/1b9d) | MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY | Descriptor: | CACODYLATE ION, PROTEIN (INTEGRASE), SULFATE ION | Authors: | Greenwald, J, Le, V, Butler, S.L, Bushman, F.D, Choe, S. | Deposit date: | 1999-02-11 | Release date: | 1999-07-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity. Biochemistry, 38, 1999
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1BIS
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![BU of 1bis by Molmil](/molmil-images/mine/1bis) | HIV-1 INTEGRASE CORE DOMAIN | Descriptor: | HIV-1 INTEGRASE | Authors: | Goldgur, Y, Dyda, F, Hickman, A.B, Jenkins, T.M, Craigie, R, Davies, D.R. | Deposit date: | 1998-06-19 | Release date: | 1998-08-19 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium. Proc.Natl.Acad.Sci.USA, 95, 1998
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1BHL
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![BU of 1bhl by Molmil](/molmil-images/mine/1bhl) | CACODYLATED CATALYTIC DOMAIN OF HIV-1 INTEGRASE | Descriptor: | HIV-1 INTEGRASE | Authors: | Maignan, S, Guilloteau, J.P, Zhou-Liu, Q, Clement-Mella, C, Mikol, V. | Deposit date: | 1998-06-10 | Release date: | 1998-10-14 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases. J.Mol.Biol., 282, 1998
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1BI4
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![BU of 1bi4 by Molmil](/molmil-images/mine/1bi4) | CATALYTIC DOMAIN OF HIV-1 INTEGRASE | Descriptor: | INTEGRASE | Authors: | Maignan, S, Guilloteau, J.P, Zhou-Liu, Q, Clement-Mella, C, Mikol, V. | Deposit date: | 1998-06-22 | Release date: | 1998-11-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases. J.Mol.Biol., 282, 1998
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1ASV
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![BU of 1asv by Molmil](/molmil-images/mine/1asv) | |
1ASW
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![BU of 1asw by Molmil](/molmil-images/mine/1asw) | AVIAN SARCOMA VIRUS INTEGRASE CATALYTIC CORE DOMAIN CRYSTALLIZED FROM 20% PEG 4000, 10% ISOPROPANOL, HEPES PH 7.5 USING SELENOMETHIONINE SUBSTITUTED PROTEIN; DATA COLLECTED AT-165 DEGREES C | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AVIAN SARCOMA VIRUS INTEGRASE, ISOPROPYL ALCOHOL | Authors: | Bujacz, G, Jaskolski, M, Alexandratos, J, Wlodawer, A. | Deposit date: | 1995-08-25 | Release date: | 1995-11-14 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | High-resolution structure of the catalytic domain of avian sarcoma virus integrase. J.Mol.Biol., 253, 1995
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1ASU
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![BU of 1asu by Molmil](/molmil-images/mine/1asu) | AVIAN SARCOMA VIRUS INTEGRASE CATALYTIC CORE DOMAIN CRYSTALLIZED FROM 2% PEG 400, 2M AMMONIUM SULFATE, HEPES PH 7.5 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AVIAN SARCOMA VIRUS INTEGRASE | Authors: | Bujacz, G, Jaskolski, M, Alexandratos, J, Wlodawer, A. | Deposit date: | 1995-08-25 | Release date: | 1995-11-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | High-resolution structure of the catalytic domain of avian sarcoma virus integrase. J.Mol.Biol., 253, 1995
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1BIZ
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![BU of 1biz by Molmil](/molmil-images/mine/1biz) | HIV-1 INTEGRASE CORE DOMAIN | Descriptor: | CACODYLATE ION, HIV-1 INTEGRASE | Authors: | Goldgur, Y, Dyda, F, Hickman, A.B, Jenkins, T.M, Craigie, R, Davies, D.R. | Deposit date: | 1998-06-21 | Release date: | 1998-08-19 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium. Proc.Natl.Acad.Sci.USA, 95, 1998
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1CXQ
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![BU of 1cxq by Molmil](/molmil-images/mine/1cxq) | ATOMIC RESOLUTION ASV INTEGRASE CORE DOMAIN FROM AMMONIUM SULFATE | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AVIAN SARCOMA VIRUS INTEGRASE, GLYCEROL | Authors: | Lubkowski, J, Dauter, Z, Yang, F, Alexandratos, J, Merkel, G, Skalka, A.M, Wlodawer, A. | Deposit date: | 1999-08-30 | Release date: | 1999-09-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.02 Å) | Cite: | Atomic resolution structures of the core domain of avian sarcoma virus integrase and its D64N mutant. Biochemistry, 38, 1999
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1CZB
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![BU of 1czb by Molmil](/molmil-images/mine/1czb) | ATOMIC RESOLUTION ASV INTEGRASE CORE DOMAIN FROM HEPES | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AVIAN SARCOMA VIRUS INTEGRASE | Authors: | Lubkowski, J, Dauter, Z, Yang, F, Alexandratos, J, Merkel, G, Skalka, A.M, Wlodawer, A. | Deposit date: | 1999-09-01 | Release date: | 1999-09-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.06 Å) | Cite: | Atomic resolution structures of the core domain of avian sarcoma virus integrase and its D64N mutant. Biochemistry, 38, 1999
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1CZ9
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![BU of 1cz9 by Molmil](/molmil-images/mine/1cz9) | ATOMIC RESOLUTION ASV INTEGRASE CORE DOMAIN (D64N) FROM CITRATE | Descriptor: | AVIAN SARCOMA VIRUS INTEGRASE, CITRIC ACID, SULFATE ION | Authors: | Lubkowski, J, Dauter, Z, Yang, F, Alexandratos, J, Merkel, G, Skalka, A.M, Wlodawer, A. | Deposit date: | 1999-09-01 | Release date: | 1999-09-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Atomic resolution structures of the core domain of avian sarcoma virus integrase and its D64N mutant. Biochemistry, 38, 1999
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1A5V
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![BU of 1a5v by Molmil](/molmil-images/mine/1a5v) | ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3 AND MN CATION | Descriptor: | 4-ACETYLAMINO-5-HYDROXYNAPHTHALENE-2,7-DISULFONIC ACID, INTEGRASE, MANGANESE (II) ION | Authors: | Lubkowski, J, Yang, F, Alexandratos, J, Wlodawer, A. | Deposit date: | 1998-02-18 | Release date: | 1998-05-27 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor. Proc.Natl.Acad.Sci.USA, 95, 1998
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1A5X
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![BU of 1a5x by Molmil](/molmil-images/mine/1a5x) | ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3 | Descriptor: | 4-ACETYLAMINO-5-HYDROXYNAPHTHALENE-2,7-DISULFONIC ACID, INTEGRASE | Authors: | Lubkowski, J, Yang, F, Alexandratos, J, Wlodawer, A. | Deposit date: | 1998-02-18 | Release date: | 1998-05-27 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor. Proc.Natl.Acad.Sci.USA, 95, 1998
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1CXU
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![BU of 1cxu by Molmil](/molmil-images/mine/1cxu) | 1.42A RESOLUTION ASV INTEGRASE CORE DOMAIN FROM CITRATE | Descriptor: | CITRIC ACID, GLYCEROL, PROTEIN (AVIAN SARCOMA VIRUS INTEGRASE) | Authors: | Lubkowski, J, Dauter, Z, Yang, F, Alexandratos, J, Wlodawer, A. | Deposit date: | 1999-08-30 | Release date: | 1999-09-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Atomic resolution structures of the core domain of avian sarcoma virus integrase and its D64N mutant. Biochemistry, 38, 1999
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1BL3
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![BU of 1bl3 by Molmil](/molmil-images/mine/1bl3) | CATALYTIC DOMAIN OF HIV-1 INTEGRASE | Descriptor: | INTEGRASE, MAGNESIUM ION | Authors: | Maignan, S, Guilloteau, J.P, Zhou-Liu, Q, Clement-Mella, C, Mikol, V. | Deposit date: | 1998-07-23 | Release date: | 1998-09-30 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases. J.Mol.Biol., 282, 1998
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