1A5V

ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3 AND MN CATION

Summary for 1A5V

DescriptorINTEGRASE, MANGANESE (II) ION, 4-ACETYLAMINO-5-HYDROXYNAPHTHALENE-2,7-DISULFONIC ACID, ... (4 entities in total)
Functional Keywordshydrolase, endonuclease, hiv-1 integrase inhibitor
Biological sourceRous sarcoma virus (strain Schmidt-Ruppin)
Cellular locationMatrix protein p19: Virion (Potential). Capsid protein p27: Virion (Potential). Nucleocapsid protein p12: Virion (Potential) P03354
Total number of polymer chains1
Total molecular weight17815.21
Authors
Lubkowski, J.,Yang, F.,Alexandratos, J.,Wlodawer, A. (deposition date: 1998-02-18, release date: 1998-05-27, Last modification date: 2011-07-13)
Primary citation
Lubkowski, J.,Yang, F.,Alexandratos, J.,Wlodawer, A.,Zhao, H.,Burke Jr., T.R.,Neamati, N.,Pommier, Y.,Merkel, G.,Skalka, A.M.
Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.
Proc.Natl.Acad.Sci.USA, 95:4831-4836, 1998
PubMed: 9560188 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.95.9.4831
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.209121.4%6.9%3.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1a5v
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Molmil generated image of 1a5v
rotated about x axis by 90°
Molmil generated image of 1a5v
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 1a5v
no rotation
Molmil generated image of 1a5v
rotated about x axis by 90°
Molmil generated image of 1a5v
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1a5v.pdb2.gz [52.64 KB])
Coordinate files for Biological unit (1a5v.pdb1.gz [52.46 KB])
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