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1A5V

ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3 AND MN CATION

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0015074biological_processDNA integration
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN A 2
ChainResidue
AASP64
AASP121
AHOH210
AHOH211
AHOH212
AHOH213

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE Y3 A 1
ChainResidue
AGLN62
ALYS119
ALYS119
AGLY145
AILE146
AALA154
AMET155
AHOH267
AHOH307
AHOH362
AHOH362
AHOH364
AHOH364

site_idACT
Number of Residues3
DetailsACTIVE SITE.
ChainResidue
AASP64
AASP121
AGLU157

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by viral protease p15 => ECO:0000303|PubMed:15102858
ChainResidueDetails
AALA136

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00457, ECO:0000269|PubMed:8805516, ECO:0000269|PubMed:9218451
ChainResidueDetails
AASP64
AASP121

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P03354, ECO:0000269|PubMed:8805516, ECO:0000269|PubMed:9218451
ChainResidueDetails
AGLU157

224004

PDB entries from 2024-08-21

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