7E1C
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![BU of 7e1c by Molmil](/molmil-images/mine/7e1c) | Structure of MreB3 from Spiroplasma eriocheiris | Descriptor: | ACETATE ION, CALCIUM ION, Cell shape-determining protein MreB | Authors: | Takahashi, D, Miyata, M, Imada, K. | Deposit date: | 2021-02-01 | Release date: | 2022-02-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | ATP-dependent polymerization dynamics of bacterial actin proteins involved in Spiroplasma swimming. Open Biology, 12, 2022
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2L4S
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![BU of 2l4s by Molmil](/molmil-images/mine/2l4s) | Promiscuous Binding at the Crossroads of Numerous Cancer Pathways: Insight from the Binding of GIP with Glutaminase L | Descriptor: | Tax1-binding protein 3 | Authors: | Zoetewey, D.L, Ovee, M, Banerjee, M, Bhaskaran, R, Mohanty, S. | Deposit date: | 2010-10-13 | Release date: | 2011-04-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Promiscuous binding at the crossroads of numerous cancer pathways: insight from the binding of glutaminase interacting protein with glutaminase L. Biochemistry, 50, 2011
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2L4T
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![BU of 2l4t by Molmil](/molmil-images/mine/2l4t) | GIP/Glutaminase L peptide complex | Descriptor: | Glutaminase L peptide, Tax1-binding protein 3 | Authors: | Zoetewey, D.L, Ovee, M, Banerjee, M, Bhaskaran, R, Mohanty, S. | Deposit date: | 2010-10-13 | Release date: | 2011-04-06 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Promiscuous binding at the crossroads of numerous cancer pathways: insight from the binding of glutaminase interacting protein with glutaminase L. Biochemistry, 50, 2011
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2KXC
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![BU of 2kxc by Molmil](/molmil-images/mine/2kxc) | 1H, 13C, and 15N Chemical Shift Assignments for IRTKS-SH3 and EspFu-R47 complex | Descriptor: | Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1, EspF-like protein | Authors: | Aitio, O, Hellman, M, Kazlauskas, A, Vingadassalom, D.F, Leong, J.M, Saksela, K, Permi, P. | Deposit date: | 2010-04-30 | Release date: | 2010-11-17 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly Proc.Natl.Acad.Sci.USA, 107, 2010
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2DAT
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![BU of 2dat by Molmil](/molmil-images/mine/2dat) | Solution structure of the Bromodomain of human SWI/SNF related matrix associated actin dependent regulator of cromatin subfamily A member 2 | Descriptor: | Possible global transcription activator SNF2L2 | Authors: | Yoneyama, M, Kigawa, T, Saito, K, Tochio, N, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-12-14 | Release date: | 2007-01-02 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the Bromodomain of human SWI/SNF related matrix associated actin dependent regulator of cromatin subfamily A member 2 To be Published
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1XI0
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![BU of 1xi0 by Molmil](/molmil-images/mine/1xi0) | X-ray crystal structure of wild-type Xerocomus chrysenteron lectin XCL | Descriptor: | lectin | Authors: | Birck, C, Damian, L, Marty-Detraves, C, Lougarre, A, Schulze-Briese, C, Koehl, P, Fournier, D, Paquereau, L, Samama, J.P. | Deposit date: | 2004-09-21 | Release date: | 2005-08-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A new lectin family with structure similarity to actinoporins revealed by the crystal structure of Xerocomus chrysenteron lectin XCL J.Mol.Biol., 344, 2004
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7O7J
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![BU of 7o7j by Molmil](/molmil-images/mine/7o7j) | Crystal structure of the human HIPK3 kinase domain bound to abemaciclib | Descriptor: | Homeodomain-interacting protein kinase 3, N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py rimidin-2-amine | Authors: | Kaltheuner, I.H, Anand, K, Geyer, M. | Deposit date: | 2021-04-13 | Release date: | 2021-11-24 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation. Nat Commun, 12, 2021
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4U7I
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![BU of 4u7i by Molmil](/molmil-images/mine/4u7i) | Structure of the complex of Spartin MIT and IST1 MIM | Descriptor: | IST1 homolog, Spartin | Authors: | Guo, E.Z, Xu, Z. | Deposit date: | 2014-07-30 | Release date: | 2015-02-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.794 Å) | Cite: | Distinct Mechanisms of Recognizing Endosomal Sorting Complex Required for Transport III (ESCRT-III) Protein IST1 by Different Microtubule Interacting and Trafficking (MIT) Domains. J.Biol.Chem., 290, 2015
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6NBF
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![BU of 6nbf by Molmil](/molmil-images/mine/6nbf) | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein | Descriptor: | CHOLESTEROL, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhao, L.-H, Ma, S, Sutkeviciute, I, Shen, D.-D, Zhou, X.E, de Waal, P.P, Li, C.-Y, Kang, Y, Clark, L.J, Jean-Alphonse, F.G, White, A.D, Xiao, K, Yang, D, Jiang, Y, Watanabe, T, Gardella, T.J, Melcher, K, Wang, M.-W, Vilardaga, J.-P, Xu, H.E, Zhang, Y. | Deposit date: | 2018-12-07 | Release date: | 2019-04-17 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure and dynamics of the active human parathyroid hormone receptor-1. Science, 364, 2019
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3CM1
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![BU of 3cm1 by Molmil](/molmil-images/mine/3cm1) | |
3CWZ
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![BU of 3cwz by Molmil](/molmil-images/mine/3cwz) | Structure of RAB6(GTP)-R6IP1 complex | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rab6-interacting protein 1, ... | Authors: | Recacha, R, Houdusse, A, Goud, B, Khan, A.R. | Deposit date: | 2008-04-23 | Release date: | 2008-11-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domain. Structure, 17, 2009
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6OCQ
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![BU of 6ocq by Molmil](/molmil-images/mine/6ocq) | Crystal structure of RIP1 kinase in complex with a pyrrolidine | Descriptor: | 1-[(2S)-2-(3-fluorophenyl)pyrrolidin-1-yl]-2,2-dimethylpropan-1-one, Receptor-interacting serine/threonine-protein kinase 1, SULFATE ION | Authors: | Thorpe, J.H, Harris, P.A. | Deposit date: | 2019-03-25 | Release date: | 2019-05-08 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.793 Å) | Cite: | Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. J.Med.Chem., 62, 2019
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7LOI
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![BU of 7loi by Molmil](/molmil-images/mine/7loi) | Model of the HIV-1 gp41 membrane-proximal external region, transmembrane domain and cytoplasmic tail | Descriptor: | Transmembrane protein gp41 | Authors: | Piai, A, Fu, Q, Sharp, A.K, Bighi, B, Brown, A.M, Chou, J.J. | Deposit date: | 2021-02-10 | Release date: | 2021-04-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR Model of the Entire Membrane-Interacting Region of the HIV-1 Fusion Protein and Its Perturbation of Membrane Morphology. J.Am.Chem.Soc., 143, 2021
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2FMU
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![BU of 2fmu by Molmil](/molmil-images/mine/2fmu) | |
3MS6
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![BU of 3ms6 by Molmil](/molmil-images/mine/3ms6) | Crystal structure of Hepatitis B X-Interacting Protein (HBXIP) | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Hepatitis B virus X-interacting protein, ... | Authors: | Garcia-Saez, I, Skoufias, D. | Deposit date: | 2010-04-29 | Release date: | 2010-11-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.085 Å) | Cite: | Structural Characterization of HBXIP: The Protein That Interacts with the Anti-Apoptotic Protein Survivin and the Oncogenic Viral Protein HBx. J.Mol.Biol., 405, 2011
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4L0R
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![BU of 4l0r by Molmil](/molmil-images/mine/4l0r) | Crystal structure of FGF2-interacting protein from Homo sapiens. Northeast Structural Genomics Consortium Target HR9027A. | Descriptor: | Centrosomal protein of 57 kDa | Authors: | Seetharaman, J, Lew, S, Su, M, Ciccosanti, C, Sahdev, S, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-05-31 | Release date: | 2013-09-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Crystal structure of FGF2-interacting protein from Homo sapiens. Northeast Structural Genomics consortium id HR9027A To be Published
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1WIM
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![BU of 1wim by Molmil](/molmil-images/mine/1wim) | Solution Structure of the RING finger Domain of the human UbcM4-interacting Protein 4 | Descriptor: | KIAA0161 protein, ZINC ION | Authors: | Miyamoto, K, Saito, K, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2004-05-28 | Release date: | 2004-11-28 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution Structure of the RING finger Domain of the human UbcM4-interacting Protein 4 To be Published
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1X5M
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7X6R
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![BU of 7x6r by Molmil](/molmil-images/mine/7x6r) | Crystal structure of actinomycin D-echinomycin-d(AGCACGT/ACGGGCT) complex | Descriptor: | 2-CARBOXYQUINOXALINE, Actinomycin D, COBALT (II) ION, ... | Authors: | Kao, S.H, Satange, R.B, Hou, M.H. | Deposit date: | 2022-03-08 | Release date: | 2022-12-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism. Nucleic Acids Res., 50, 2022
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7X97
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![BU of 7x97 by Molmil](/molmil-images/mine/7x97) | Crystal structure of actinomycin D-echinomycin-d(AGCCCGT/ACGGGCT) complex | Descriptor: | 2-CARBOXYQUINOXALINE, Actinomycin D, CHLORIDE ION, ... | Authors: | Kao, S.H, Satange, R.B, Hou, M.H. | Deposit date: | 2022-03-15 | Release date: | 2022-12-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism. Nucleic Acids Res., 50, 2022
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5DZ6
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![BU of 5dz6 by Molmil](/molmil-images/mine/5dz6) | Acyl transferase from Bacillaene PKS | Descriptor: | 1,2-ETHANEDIOL, BROMIDE ION, CHLORIDE ION, ... | Authors: | Till, M, Race, P.R. | Deposit date: | 2015-09-25 | Release date: | 2016-10-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Architectural hierarchy of trans-acting enoyl reductases from polyunsaturated fatty acid and trans-acyltransferase polyketide synthases To Be Published
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4NIQ
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![BU of 4niq by Molmil](/molmil-images/mine/4niq) | Crystal Structure of Vps4 MIT-Vfa1 MIM2 | Descriptor: | VPS4-associated protein 1, Vacuolar protein sorting-associated protein 4 | Authors: | Vild, C.J, Xu, Z. | Deposit date: | 2013-11-06 | Release date: | 2014-03-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Vfa1 Binds to the N-terminal Microtubule-interacting and Trafficking (MIT) Domain of Vps4 and Stimulates Its ATPase Activity. J.Biol.Chem., 289, 2014
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6SVL
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![BU of 6svl by Molmil](/molmil-images/mine/6svl) | |
6SVK
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![BU of 6svk by Molmil](/molmil-images/mine/6svk) | human Myeloid-derived growth factor (MYDGF) | Descriptor: | MALONATE ION, Myeloid-derived growth factor | Authors: | Ebenhoch, R, Nar, H. | Deposit date: | 2019-09-18 | Release date: | 2019-11-27 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (1.604 Å) | Cite: | Crystal structure and receptor-interacting residues of MYDGF - a protein mediating ischemic tissue repair. Nat Commun, 10, 2019
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2RGU
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![BU of 2rgu by Molmil](/molmil-images/mine/2rgu) | Crystal structure of complex of human DPP4 and inhibitor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-d ione, Dipeptidyl peptidase 4 | Authors: | Nar, H, Himmelsbach, F, Eckhardt, M. | Deposit date: | 2007-10-05 | Release date: | 2007-11-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | 8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes. J.Med.Chem., 50, 2007
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