1O5Z
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6KTN
| Human PPARgamma ligand-binding domain R288A mutant in complex with imatinib | Descriptor: | 16-mer peptide from Nuclear receptor coactivator 1, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Peroxisome proliferator-activated receptor gamma | Authors: | Jang, J.Y, Han, B.W. | Deposit date: | 2019-08-28 | Release date: | 2020-02-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.752 Å) | Cite: | Structural Basis for the Regulation of PPAR gamma Activity by Imatinib. Molecules, 24, 2019
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4PPS
| Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with an A-CD ring estrogen derivative | Descriptor: | (1S,3aR,5R,7aS)-5-(4-hydroxyphenyl)-7a-methyloctahydro-1H-inden-1-ol, Estrogen receptor, Nuclear receptor coactivator 2 | Authors: | Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Parent, A.A, Hughes, T.S, Pollock, J.A, Gjyshi, O, Cavett, V, Nowak, J, Garcia-Ordonez, R.D, Houtman, R, Griffin, P.R, Kojetin, D.J, Katzenellenbogen, J.A, Conkright, M.D, Nettles, K.W. | Deposit date: | 2014-02-27 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.929 Å) | Cite: | Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. Elife, 3, 2014
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4PPP
| Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Fluoro-Resveratrol | Descriptor: | 5-[(E)-2-(3-fluoro-4-hydroxyphenyl)ethenyl]benzene-1,3-diol, Estrogen receptor, Nuclear receptor coactivator 2 | Authors: | Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Parent, A.A, Hughes, T.S, Pollock, J.A, Gjyshi, O, Cavett, V, Nowak, J, Garcia-Ordonez, R.D, Houtman, R, Griffin, P.R, Kojetin, D.J, Katzenellenbogen, J.A, Conkright, M.D, Nettles, K.W. | Deposit date: | 2014-02-27 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.686 Å) | Cite: | Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. Elife, 3, 2014
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2HDP
| Solution Structure of Hdm2 RING Finger Domain | Descriptor: | Ubiquitin-protein ligase E3 Mdm2, ZINC ION | Authors: | Kostic, M, Matt, T, Yamout-Martinez, M, Dyson, H.J, Wright, P.E. | Deposit date: | 2006-06-20 | Release date: | 2006-11-21 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53. J.Mol.Biol., 363, 2006
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1S9P
| crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with diethylstilbestrol | Descriptor: | DIETHYLSTILBESTROL, Estrogen-related receptor gamma | Authors: | Greschik, H, Flaig, R, Renaud, J.P, Moras, D. | Deposit date: | 2004-02-05 | Release date: | 2004-06-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Structural Basis for the Deactivation of the Estrogen-related Receptor {gamma} by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity. J.Biol.Chem., 279, 2004
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6T5J
| Structure of NUDT15 in complex with inhibitor TH1760 | Descriptor: | 6-[4-(1~{H}-indol-5-ylcarbonyl)piperazin-1-yl]sulfonyl-3~{H}-1,3-benzoxazol-2-one, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Carter, M, Rehling, D, Desroses, M, Zhang, S.M, Hagenkort, A, Valerie, N.C.K, Helleday, T, Stenmark, P. | Deposit date: | 2019-10-16 | Release date: | 2020-07-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Development of a chemical probe against NUDT15. Nat.Chem.Biol., 16, 2020
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6TF8
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6TJV
| Structure of the NDH-1MS complex from Thermosynechococcus elongatus | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, BETA-CAROTENE, ... | Authors: | Schuller, J.M, Saura, P, Thiemann, J, Schuller, S.K, Gamiz-Hernandez, A.P, Kurisu, G, Nowaczyk, M.M, Kaila, V.R.I. | Deposit date: | 2019-11-27 | Release date: | 2020-02-19 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Redox-coupled proton pumping drives carbon concentration in the photosynthetic complex I. Nat Commun, 11, 2020
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6T7L
| Crystal structure of AmpC from E.coli with Nacubactam (OP0595) | Descriptor: | (2S,5R)-N-(2-aminoethoxy)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-lactamase, ... | Authors: | Lang, P.A, Leissing, T.M, Schofield, C.J, Brem, J. | Deposit date: | 2019-10-22 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Structural Investigations of the Inhibition of Escherichia coli AmpC beta-Lactamase by Diazabicyclooctanes. Antimicrob.Agents Chemother., 65, 2021
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4JWX
| GluN2A ligand-binding core in complex with propyl-NHP5G | Descriptor: | (2R)-amino(1-hydroxy-4-propyl-1H-pyrazol-5-yl)ethanoic acid, GluN2A | Authors: | Hansen, K.B, Tajima, N, Risgaard, R, Perszyk, R.E, Jorgensen, L, Vance, K.M, Ogden, K.K, Clausen, R.P, Furukawa, H, Traynelis, S.F. | Deposit date: | 2013-03-27 | Release date: | 2013-05-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-d-aspartate receptors. Mol.Pharmacol., 84, 2013
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6TFA
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4J6G
| CRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEX | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Liu, W, Zhan, C, Bonanno, J.B, Bhosle, R.C, Nathenson, S.G, Almo, S.C, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2013-02-11 | Release date: | 2013-03-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure, 22, 2014
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6TPM
| Crystal structure of AmpC from E.coli with Relebactam (MK-7655) | Descriptor: | (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-lactamase, ... | Authors: | Lang, P.A, Leissing, T.M, Schofield, C.J, Brem, J. | Deposit date: | 2019-12-13 | Release date: | 2020-11-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Structural Investigations of the Inhibition of Escherichia coli AmpC beta-Lactamase by Diazabicyclooctanes. Antimicrob.Agents Chemother., 65, 2021
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4GAC
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6L7P
| cryo-EM structure of cyanobacteria NDH-1LdelV complex | Descriptor: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, BETA-CAROTENE, ... | Authors: | Zhang, C, Shuai, J, Wu, J, Lei, M. | Deposit date: | 2019-11-02 | Release date: | 2020-02-19 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural insights into NDH-1 mediated cyclic electron transfer. Nat Commun, 11, 2020
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6L35
| PSI-LHCI Supercomplex from Physcometrella patens | Descriptor: | (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | Authors: | Zhao, L, Yan, Q.J, Qin, X.C. | Deposit date: | 2019-10-09 | Release date: | 2021-02-10 | Last modified: | 2021-03-03 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Antenna arrangement and energy-transfer pathways of PSI-LHCI from the moss Physcomitrella patens. Cell Discov, 7, 2021
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6TGW
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1MTO
| Crystal structure of a Phosphofructokinase mutant from Bacillus stearothermophilus bound with fructose-6-phosphate | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, 6-phosphofructokinase | Authors: | Riley-Lovingshimer, M.R, Ronning, D.R, Sacchettini, J.C, Reinhart, G.D. | Deposit date: | 2002-09-21 | Release date: | 2002-12-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Reversible Ligand-Induced Dissociation of a Tryptophan-Shift Mutant of Phosphofructokinase
from Bacillus stearothermophilus Biochemistry, 41, 2002
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1ITQ
| HUMAN RENAL DIPEPTIDASE | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, RENAL DIPEPTIDASE, ZINC ION | Authors: | Nitanai, Y, Satow, Y, Adachi, H, Tsujimoto, M. | Deposit date: | 2002-02-02 | Release date: | 2002-08-28 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of Human Renal Dipeptidase Involved in beta-Lactam Hydrolysis J.Mol.Biol., 321, 2002
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2LAJ
| Third WW domain of human Nedd4L in complex with doubly phosphorylated human smad3 derived peptide | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like, Mothers against decapentaplegic homolog 3 | Authors: | Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J. | Deposit date: | 2011-03-16 | Release date: | 2011-07-06 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev., 25, 2011
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6U73
| Human Angiopoietin-Like 4 C-Terminal Domain (cANGPTL4) with Myristic Acid | Descriptor: | Angiopoietin-related protein 4, MYRISTIC ACID | Authors: | Tarver, C.L, Yuan, Q, Singhal, A.J, Ramaker, R, Cooper, S, Pusey, M.L. | Deposit date: | 2019-08-31 | Release date: | 2019-10-09 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Crystal Structures of Angiopoietin-Like 4s C-Terminal Domain (cANGPTL4) Reveal a Binding Site for Various Ligands To Be Published
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2GGU
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5J3X
| Structure of c-CBL Y371F | Descriptor: | CALCIUM ION, E3 ubiquitin-protein ligase CBL, ZINC ION | Authors: | Huang, D.T, Buetow, L, Dou, H. | Deposit date: | 2016-03-31 | Release date: | 2016-09-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.822 Å) | Cite: | Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation. Bmc Biol., 14, 2016
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1R5D
| X-ray structure of bovine seminal ribonuclease swapping dimer from a new crystal form | Descriptor: | Ribonuclease, seminal | Authors: | Merlino, A, Vitagliano, L, Sica, F, Zagari, A, Mazzarella, L. | Deposit date: | 2003-10-10 | Release date: | 2004-04-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer Biopolymers, 73, 2004
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