PDB: 8717 resultsInfo pagesStatus searchChemie searchBIRD

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5KI6	Human Argonaute-2 bound to a guide RNA with a nucleobase modification at position 1 Descriptor: PHENOL, Protein argonaute-2, miR-122 Authors: Schirle, N.T, MacRae, I.J. Deposit date: 2016-06-16 Release date: 2016-07-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.153 Å) Cite: Structure-Guided Control of siRNA Off-Target Effects. J.Am.Chem.Soc., 138, 2016
6W1S	Atomic model of the mammalian Mediator complex Descriptor: Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... Authors: Zhao, H, Young, N, Asturias, F. Deposit date: 2020-03-04 Release date: 2021-03-10 Method: ELECTRON MICROSCOPY (4.02 Å) Cite: A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers. Cell, 178, 2019
6JCX	Mycobacterium tuberculosis transcription initiation complex with ECF sigma factor sigma H and 6nt RNA Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2019-01-30 Release date: 2019-05-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.903 Å) Cite: Structures and mechanism of transcription initiation by bacterial ECF factors. Nucleic Acids Res., 47, 2019
6JBQ	CryoEM structure of Escherichia coli sigmaE transcription initiation complex containing 5nt of RNA Descriptor: DNA (48-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Fang, C.L, Zhang, Y. Deposit date: 2019-01-26 Release date: 2019-05-29 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (4.02 Å) Cite: Structures and mechanism of transcription initiation by bacterial ECF factors. Nucleic Acids Res., 47, 2019
6ZOK	SARS-CoV-2-Nsp1-40S complex, focused on body Descriptor: 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S13, ... Authors: Schubert, K, Karousis, E.D, Jomaa, A, Scaiola, A, Echeverria, B, Gurzeler, L.-A, Leibundgut, M, Thiel, V, Muehlemann, O, Ban, N. Deposit date: 2020-07-07 Release date: 2020-07-29 Last modified: 2021-02-10 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation. Nat.Struct.Mol.Biol., 27, 2020
7OLE	Cryo-EM structure of the TELO2-TTI1-TTI2-RUVBL1-RUVBL2 complex Descriptor: ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2, ... Authors: Pal, M, Llorca, O, Pearl, L. Deposit date: 2021-05-19 Release date: 2021-07-07 Last modified: 2021-10-06 Method: ELECTRON MICROSCOPY (3.41 Å) Cite: Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone. Cell Rep, 36, 2021
7AAV	Human pre-Bact-2 spliceosome core structure Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, D-chiro inositol hexakisphosphate, ... Authors: Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. Deposit date: 2020-09-04 Release date: 2020-12-09 Last modified: 2020-12-30 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
6AR3	Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications (RT/Duplex (Se-Met)) Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA, GsI-IIC RT, ... Authors: Stamos, J.L, Lentzsch, A.M, Lambowitz, A.M. Deposit date: 2017-08-21 Release date: 2017-11-29 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.41 Å) Cite: Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications. Mol. Cell, 68, 2017
6AR1	Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications (RT/Duplex (Nat)) Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA, GsI-IIC RT, ... Authors: Stamos, J.L, Lentzsch, A.M, Lambowitz, A.M. Deposit date: 2017-08-21 Release date: 2017-11-29 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.01 Å) Cite: Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications. Mol. Cell, 68, 2017
7MLB	Crystal structure of Thermus thermophilus transcription initiation complex with 5nt RNA Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*AP*GP*GP*GP*AP*TP*GP*CP*AP*G)-3'), DNA (5'-D(P*CP*TP*GP*CP*AP*TP*CP*CP*CP*TP*GP*AP*GP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, Y, Ebright, R.H. Deposit date: 2021-04-28 Release date: 2022-02-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
6H02	Crystal structure of human Mediator subunit MED23 Descriptor: LAMA nanobody NB106, Mediator of RNA polymerase II transcription subunit 23 Authors: Clantin, B, Monte, D, Villeret, V. Deposit date: 2018-07-06 Release date: 2018-08-29 Last modified: 2018-09-05 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structure of human Mediator subunit MED23. Nat Commun, 9, 2018
6ZOL	SARS-CoV-2-Nsp1-40S complex, focused on head Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S12, ... Authors: Schubert, K, Karousis, E.D, Jomaa, A, Scaiola, A, Echeverria, B, Gurzeler, L.-A, Leibundgut, M.L, Thiel, V, Muehlemann, O, Ban, N. Deposit date: 2020-07-07 Release date: 2020-07-22 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation. Nat.Struct.Mol.Biol., 27, 2020
8DDB	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 4-(benzyloxy)-6-bromo-3-hydroxypicolinic acid Descriptor: 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid, ACETATE ION, MANGANESE (II) ION, ... Authors: Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. Deposit date: 2022-06-17 Release date: 2022-12-21 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
8CTF	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid Descriptor: 3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid, ACETATE ION, MANGANESE (II) ION, ... Authors: Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. Deposit date: 2022-05-14 Release date: 2022-12-21 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
7MLJ	Crystal structure of Thermus thermophilus reiterative transcription complex with 4nt oligo-G RNA Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*GP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*CP*GP*TP*GP*CP*CP*CP*TP*GP*AP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, Y, Ebright, R.H. Deposit date: 2021-04-28 Release date: 2022-02-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.75 Å) Cite: Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
8BY6	Structure of the human nuclear cap-binding complex bound to NCBP3(560-620) and cap-analogue m7GpppG Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ... Authors: Dubiez, E, Pellegrini, E, Foucher, A.E, Cusack, S, Kadlec, J. Deposit date: 2022-12-12 Release date: 2024-01-24 Last modified: 2024-01-31 Method: ELECTRON MICROSCOPY (3.19 Å) Cite: Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex. Cell Rep, 43, 2024
7OM9	Thosea asigna virus RdRP domain Descriptor: RNA-dependent RNA polymerase Authors: Ferrero, D.S, Falqui, M, Verdaguer, N. Deposit date: 2021-05-21 Release date: 2021-07-28 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3 Å) Cite: Snapshots of a Non-Canonical RdRP in Action. Viruses, 13, 2021
7EH0	Thermus thermophilus RNA polymerase transcription initiation complex containing a template-strand purine at position TSS-2, UpA RNA primer and CMPcPP Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (27-MER), DNA (5'-D(*CP*C*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*AP*AP*AP*G)-3'), ... Authors: Li, L, Zhang, Y. Deposit date: 2021-03-27 Release date: 2021-07-14 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.808 Å) Cite: Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli . Proc.Natl.Acad.Sci.USA, 118, 2021
7MLI	Crystal structure of Thermus thermophilus reiterative transcription complex with 5nt oligo-C RNA Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*CP*TP*AP*CP*GP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*CP*GP*TP*AP*GP*GP*GP*CP*GP*GP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, Y, Ebright, R.H. Deposit date: 2021-04-28 Release date: 2022-02-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
6G0R	Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated POLR2A peptide (K775ac/K778ac) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, DNA-directed RNA polymerase II subunit RPB1 Authors: Filippakopoulos, P, Picaud, S, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C. Deposit date: 2018-03-19 Release date: 2018-11-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol. Cell, 73, 2019
7ORI	La Crosse virus polymerase at replication late-elongation stage Descriptor: La Crosse virus polymerase, MAGNESIUM ION, PYROPHOSPHATE 2-, ... Authors: Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. Deposit date: 2021-06-06 Release date: 2022-02-16 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription. Nat Commun, 13, 2022
7ORO	La Crosse virus polymerase at replication early-elongation stage Descriptor: La Crosse virus polymerase, MAGNESIUM ION, RNA (5'-R(P*AP*CP*GP*AP*GP*UP*GP*UP*CP*GP*UP*AP*CP*C)-3'), ... Authors: Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. Deposit date: 2021-06-06 Release date: 2022-02-16 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription. Nat Commun, 13, 2022
8GWM	SARS-CoV-2 E-RTC bound with MMP-nsp9 and GMPPNP Descriptor: 2'-deoxy-2'-fluoro-2'-methyluridine 5'-(trihydrogen diphosphate), Helicase, Non-structural protein 7, ... Authors: Yan, L.M, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2024-02-28 Method: ELECTRON MICROSCOPY (2.64 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
6FXC	The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... Authors: Matzov, D, Aibara, S, Zimmerman, E, Bashan, A, Kidmose, R, Amunts, A, Yonath, A. Deposit date: 2018-03-08 Release date: 2018-03-21 Last modified: 2018-11-21 Method: ELECTRON MICROSCOPY (6.76 Å) Cite: The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus. Nat Commun, 8, 2017
7OMB	Crystal structure of KOD DNA Polymerase in a ternary complex with a p/t duplex containing an extended 5' single stranded template overhang Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA polymerase, ... Authors: Betz, K, Kropp, H.M, Diederichs, K, Marx, A. Deposit date: 2021-05-21 Release date: 2021-10-13 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Structural Basis for The Recognition of Deaminated Nucleobases by An Archaeal DNA Polymerase. Chembiochem, 22, 2021

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