PDB: 10243 resultsInfo pagesStatus searchChemie searchBIRD

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8P7D	CryoEM structure of METTL6 tRNA SerRS complex in a 1:1:2 stoichiometry Descriptor: MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, Serine tRNA, ... Authors: Throll, P, Dolce, L.G, Kowalinski, E. Deposit date: 2023-05-30 Release date: 2024-06-12 Last modified: 2024-10-30 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structural basis of tRNA recognition by the m 3 C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase. Nat.Struct.Mol.Biol., 31, 2024
8P7B	CryoEM structure of METTL6 tRNA SerRS complex in a 1:2:2 stoichiometry Descriptor: MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, Serine tRNA, ... Authors: Throll, P, Dolce, L.G, Kowalinski, E. Deposit date: 2023-05-30 Release date: 2024-06-12 Last modified: 2024-10-30 Method: ELECTRON MICROSCOPY (2.42 Å) Cite: Structural basis of tRNA recognition by the m 3 C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase. Nat.Struct.Mol.Biol., 31, 2024
8P7C	CryoEM structure of METTL6 tRNA SerRS complex in a 2:2:2 stoichiometry Descriptor: MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, Serine tRNA, ... Authors: Throll, P, Dolce, L.G, Kowalinski, E. Deposit date: 2023-05-30 Release date: 2024-06-12 Last modified: 2025-07-09 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural basis of tRNA recognition by the m 3 C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase. Nat.Struct.Mol.Biol., 31, 2024
9I8V	Cryo-EM structure of the Danio rerio tRNA ligase complex Descriptor: ATP-dependent RNA helicase, Ashwin, Family with sequence similarity 98, ... Authors: Chamera, S, Zajko, W, Czarnocki-Cieciura, M, Jaciuk, M, Koziej, L, Nowak, J, Wycisk, K, Sroka, M, Chramiec-Glabik, A, Smietanski, M, Golebiowski, F, Warminski, M, Jemielity, J, Glatt, S, Nowotny, M. Deposit date: 2025-02-06 Release date: 2025-04-23 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (3.33 Å) Cite: Structural and biochemical characterization of the 3'-5' tRNA splicing ligases. J.Biol.Chem., 301, 2025
9DCH	Single-stranded RNA-mediated PRC2 dimer Descriptor: Isoform 2 of Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ... Authors: Song, J.S, Kasinath, V.K. Deposit date: 2024-08-26 Release date: 2025-03-12 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Diverse RNA Structures Induce PRC2 Dimerization and Inhibit Histone Methyltransferase Activity. Biorxiv, 2024
5FJ6	Structure of the P2 polymerase inside in vitro assembled bacteriophage phi6 polymerase complex Descriptor: MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE Authors: Ilca, S, Kotecha, A, Sun, X, Poranen, M.P, Stuart, D.I, Huiskonen, J.T. Deposit date: 2015-10-06 Release date: 2015-11-04 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (7.9 Å) Cite: Localized Reconstruction of Subunits from Electron Cryomicroscopy Images of Macromolecular Complexes. Nat.Commun., 6, 2015
8CWR	Complex structure of WhiB3 and the SigmaAr4-RNAP Beta flap tip chimera in space group R3 Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, IRON/SULFUR CLUSTER, NICKEL (II) ION, ... Authors: Wan, T, Zhang, L. Deposit date: 2022-05-19 Release date: 2023-05-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural basis of DNA binding by the WhiB-like transcription factor WhiB3 in Mycobacterium tuberculosis. J.Biol.Chem., 299, 2023
8CWT	Complex structure of WhiB3 and the SigmaAr4-RNAP Beta flap tip chimera in space group P43212 Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, IRON/SULFUR CLUSTER, NICKEL (II) ION, ... Authors: Wan, T, Zhang, L. Deposit date: 2022-05-19 Release date: 2023-05-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Structural basis of DNA binding by the WhiB-like transcription factor WhiB3 in Mycobacterium tuberculosis. J.Biol.Chem., 299, 2023
1BT6	P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS Descriptor: ANNEXIN II, S100A10 Authors: Rety, S, Sopkova, J, Renouard, M, Osterloh, D, Gerke, V, Russo-Marie, F, Lewit-Bentley, A. Deposit date: 1998-09-02 Release date: 1999-01-27 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The crystal structure of a complex of p11 with the annexin II N-terminal peptide. Nat.Struct.Biol., 6, 1999
5FJ7	Structure of the P2 polymerase inside in vitro assembled bacteriophage phi6 polymerase complex, with P1 included Descriptor: MAJOR INNER PROTEIN P1, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE Authors: Ilca, S, Kotecha, A, Sun, X, Poranen, M.P, Stuart, D.I, Huiskonen, J.T. Deposit date: 2015-10-06 Release date: 2015-11-04 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (7.9 Å) Cite: Localized Reconstruction of Subunits from Electron Cryomicroscopy Images of Macromolecular Complexes. Nat.Commun., 6, 2015
5W1S	X-ray crystal structure of Escherichia coli RNA polymerase and TraR complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Murakami, K.S, Molodtsov, V. Deposit date: 2017-06-04 Release date: 2017-06-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.805 Å) Cite: Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA. Mol. Cell, 69, 2018
6CUX	Escherichia coli RpoB S531L mutant RNA polymerase holoenzyme in complex with Kanglemycin A Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Molodtsov, V, Murakami, K.S. Deposit date: 2018-03-26 Release date: 2018-07-25 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (4.104 Å) Cite: Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. Mol. Cell, 72, 2018
3MF5	Hepatitis C virus polymerase NS5B (BK) with amide bioisostere thumb site inhibitor Descriptor: 3-[2-(trans-4-methylcyclohexyl)phenyl]-5-phenylthiophene-2-carboxylic acid, GLYCEROL, RNA-directed RNA polymerase Authors: Harris, S.F, Tavares, G, Ghate, M. Deposit date: 2010-04-01 Release date: 2010-07-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2 Å) Cite: Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
5ZC9	Crystal structure of the human eIF4A1-ATP analog-RocA-polypurine RNA complex Descriptor: (1R,2R,3S,3aR,8bS)-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-1,8b-bis(oxidanyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide, Eukaryotic initiation factor 4A-I, MAGNESIUM ION, ... Authors: Iwasaki, W, Takahashi, M, Sakamoto, A, Iwasaki, S, Ito, T. Deposit date: 2018-02-16 Release date: 2019-01-16 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA. Mol. Cell, 73, 2019
4AWK	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1 Descriptor: (2Z)-4-[(3S)-1-(benzylsulfonyl)-3-(4-chlorobenzyl)piperidin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid, MANGANESE (II) ION, POLYMERASE PA Authors: Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. Deposit date: 2012-06-04 Release date: 2012-08-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
8KG8	Yeast replisome in state II Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (61-mer), ... Authors: Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. Deposit date: 2023-08-17 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (4.23 Å) Cite: Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun, 14, 2023
1Q79	CRYSTAL STRUCTURE OF MAMMALIAN POLY(A) POLYMERASE Descriptor: 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MANGANESE (II) ION, ... Authors: Martin, G, Moglich, A, Keller, W, Doublie, S. Deposit date: 2003-08-16 Release date: 2004-09-07 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase. J.Mol.Biol., 341, 2004
4AWM	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with (-)-epigallocatechin gallate from green tea Descriptor: (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, MANGANESE (II) ION, POLYMERASE PA Authors: Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. Deposit date: 2012-06-04 Release date: 2012-08-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
3FBN	Structure of the Mediator submodule Med7N/31 Descriptor: Mediator of RNA polymerase II transcription subunit 31, Mediator of RNA polymerase II transcription subunit 7 Authors: Koschubs, T, Seizl, M, Lariviere, L, Kurth, F, Baumli, S, Martin, D.E, Cramer, P. Deposit date: 2008-11-19 Release date: 2008-12-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.007 Å) Cite: Identification, structure, and functional requirement of the Mediator submodule Med7N/31 Embo J., 28, 2009
4AWH	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with rUMP Descriptor: MANGANESE (II) ION, POLYMERASE PA, URIDINE-5'-MONOPHOSPHATE Authors: Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. Deposit date: 2012-06-03 Release date: 2012-08-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
4AVG	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 2 Descriptor: (Z)-4-[4-[(4-chlorophenyl)methyl]-1-(cyclohexylmethyl)piperidin-4-yl]-2-oxidanyl-4-oxidanylidene-but-2-enoic acid, MANGANESE (II) ION, POLYMERASE PA Authors: Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. Deposit date: 2012-05-25 Release date: 2012-08-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
4AWF	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with 2 4-dioxo-4-phenylbutanoic acid DPBA Descriptor: 2-4-DIOXO-4-PHENYLBUTANOIC ACID, MANGANESE (II) ION, POLYMERASE PA Authors: Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. Deposit date: 2012-06-03 Release date: 2012-08-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
4AWG	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 3 Descriptor: (2Z)-4-[(3S)-1-benzyl-3-(4-chlorobenzyl)piperidin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid, MANGANESE (II) ION, POLYMERASE PA, ... Authors: Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. Deposit date: 2012-06-03 Release date: 2012-08-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
4M5D	Crystal structure of the Utp22 and Rrp7 complex from Saccharomyces cerevisiae Descriptor: Ribosomal RNA-processing protein 7, SULFATE ION, TRIETHYLENE GLYCOL, ... Authors: Lin, J, Ye, K. Deposit date: 2013-08-08 Release date: 2013-11-06 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.97 Å) Cite: An RNA-Binding Complex Involved in Ribosome Biogenesis Contains a Protein with Homology to tRNA CCA-Adding Enzyme. Plos Biol., 11, 2013
2BPC	CRYSTAL STRUCTURE OF RAT DNA POLYMERASE BETA: EVIDENCE FOR A COMMON POLYMERASE MECHANISM Descriptor: DNA POLYMERASE BETA, MANGANESE (II) ION Authors: Sawaya, M.R, Pelletier, H, Kumar, A, Wilson, S.H, Kraut, J. Deposit date: 1994-07-08 Release date: 1994-08-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism. Science, 264, 1994

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