7E0A
| X-ray structure of human PPARgamma ligand binding domain-saroglitazar co-crystals obtained by co-crystallization | Descriptor: | (2S)-2-ethoxy-3-[4-[2-[2-methyl-5-(4-methylsulfanylphenyl)pyrrol-1-yl]ethoxy]phenyl]propanoic acid, Isoform 2 of Peroxisome proliferator-activated receptor gamma | Authors: | Kamata, S, Honda, A, Uchii, K, Machida, Y, Oyama, T, Ishii, I. | Deposit date: | 2021-01-27 | Release date: | 2021-09-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.771 Å) | Cite: | Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR alpha / gamma Dual Agonist. Biol.Pharm.Bull., 44, 2021
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5O4F
| Structure of GluK3 ligand-binding domain (S1S2) in complex with the agonist LM-12b at 2.10 A resolution | Descriptor: | (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid, ACETATE ION, CHLORIDE ION, ... | Authors: | Moellerud, S, Frydenvang, K, Kastrup, J.S. | Deposit date: | 2017-05-29 | Release date: | 2017-07-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors. ACS Chem Neurosci, 8, 2017
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2MQ1
| Phosphotyrosine binding domain | Descriptor: | E3 ubiquitin-protein ligase Hakai, ZINC ION | Authors: | Mukherjee, M, Jing-Song, F, Sivaraman, J. | Deposit date: | 2014-06-11 | Release date: | 2014-08-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Dimeric switch of Hakai-truncated monomers during substrate recognition: insights from solution studies and NMR structure. J.Biol.Chem., 289, 2014
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7QB9
| Structure of the ligand-free GPCR dimer Ste2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Pheromone alpha factor receptor | Authors: | Velazhahan, V, Tate, C.G. | Deposit date: | 2021-11-18 | Release date: | 2022-03-16 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Activation mechanism of the class D fungal GPCR dimer Ste2. Nature, 603, 2022
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3ME6
| Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel | Descriptor: | Clopidogrel, Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Gay, S.C, Roberts, A.G, Maekawa, K, Talakad, J.C, Hong, W.X, Zhang, Q, Stout, C.D, Halpert, J.R. | Deposit date: | 2010-03-31 | Release date: | 2010-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel. Biochemistry, 49, 2010
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5JRU
| Crystal structure of Fe(II) unliganded H-NOX protein from C. subterraneus | Descriptor: | Methyl-accepting chemotaxis protein, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Bruegger, J, Hespen, C, Phillips-Piro, C.M, Marletta, M.A. | Deposit date: | 2016-05-06 | Release date: | 2016-07-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.305 Å) | Cite: | Structural and Functional Evidence Indicates Selective Oxygen Signaling in Caldanaerobacter subterraneus H-NOX. Acs Chem.Biol., 11, 2016
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4WRY
| Crystal structure of Mycobacterium tuberculosis uracil-DNA glycosylase in complex with 5-fluorouracil(B), Form I | Descriptor: | 5-FLUOROURACIL, CHLORIDE ION, CITRIC ACID, ... | Authors: | Arif, S.M, Geethanandan, K, Mishra, P, Surolia, A, Varshney, U, Vijayan, M. | Deposit date: | 2014-10-25 | Release date: | 2015-07-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Structural plasticity in Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) and its functional implications. Acta Crystallogr.,Sect.D, 71, 2015
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5JBQ
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8IMY
| Cryo-EM structure of GPI-T (inactive mutant) with GPI and proULBP2, a proprotein substrate | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Li, T, Xu, Y, Qu, Q, Li, D. | Deposit date: | 2023-03-07 | Release date: | 2023-08-16 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis. Nat Commun, 14, 2023
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6Y2X
| RING-DTC domains of Deltex 2, Form 2 | Descriptor: | Probable E3 ubiquitin-protein ligase DTX2, ZINC ION | Authors: | Gabrielsen, M, Buetow, L, Huang, D.T. | Deposit date: | 2020-02-17 | Release date: | 2020-09-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination. Sci Adv, 6, 2020
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6Y3J
| RING-DTC domains of Deltex 2, bound to ADP-ribose | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Probable E3 ubiquitin-protein ligase DTX2, ZINC ION | Authors: | Gabrielssen, M, Buetow, L, Huang, D.T. | Deposit date: | 2020-02-18 | Release date: | 2020-09-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination. Sci Adv, 6, 2020
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8I9O
| ecCTPS filament bound with CTP, NADH, DON | Descriptor: | 5-OXO-L-NORLEUCINE, ADENINE, CTP synthase, ... | Authors: | Guo, C.J, Liu, J.L. | Deposit date: | 2023-02-07 | Release date: | 2024-02-14 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Filamentation and inhibition of prokaryotic CTP synthase with ligands. Mlife, 3, 2024
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6Y22
| RING-DTC domains of Deltex 2, Form 1 | Descriptor: | Probable E3 ubiquitin-protein ligase DTX2, ZINC ION | Authors: | Gabrielssen, M, Buetow, L, Huang, D.T. | Deposit date: | 2020-02-14 | Release date: | 2020-09-02 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.069 Å) | Cite: | DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination. Sci Adv, 6, 2020
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3UAS
| Cytochrome P450 2B4 covalently bound to the mechanism-based inactivator 9-ethynylphenanthrene | Descriptor: | 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Gay, S.C, Zhang, H, Shah, M.B, Stout, C.D, Halpert, J.R, Hollenberg, P.F. | Deposit date: | 2011-10-21 | Release date: | 2013-01-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.939 Å) | Cite: | Potent Mechanism-Based Inactivation of Cytochrome P450 2B4 by 9-Ethynylphenanthrene: Implications for Allosteric Modulation of Cytochrome P450 Catalysis. Biochemistry, 52, 2013
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2FR4
| Structure of Fab DNA-1 complexed with a stem-loop DNA ligand | Descriptor: | 5'-D(*CP*TP*GP*CP*CP*TP*TP*CP*AP*G)-3', TETRAETHYLENE GLYCOL, antibody heavy chain FAB, ... | Authors: | Tanner, J.J, Ou, Z. | Deposit date: | 2006-01-18 | Release date: | 2007-01-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Impact of DNA hairpin folding energetics on antibody-ssDNA association. J.Mol.Biol., 374, 2007
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3UHK
| HBI (K96R) without ligand bound | Descriptor: | Globin-1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Ren, Z, Srajer, V, Knapp, J.E, Royer Jr, W.E. | Deposit date: | 2011-11-03 | Release date: | 2011-12-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Cooperative macromolecular device revealed by meta-analysis of static and time-resolved structures. Proc.Natl.Acad.Sci.USA, 109, 2012
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5DIN
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2V2V
| IspE in complex with ligand | Descriptor: | 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, 5'-[(1H-BENZIMIDAZOL-2-YLACETYL)AMINO]-5'-DEOXYCYTIDINE, BROMIDE ION, ... | Authors: | Alphey, M.S, Hunter, W.N. | Deposit date: | 2007-06-07 | Release date: | 2007-06-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase Ispe of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis. Chemmedchem, 3, 2008
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2V2Q
| IspE in complex with ligand | Descriptor: | 4-AMINO-1-(5-{[3-(1H-BENZIMIDAZOL-2-YL)PROPANOYL]AMINO}-5-DEOXY-ALPHA-L-LYXOFURANOSYL)PYRIMIDIN-2(1H)-ONE, 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE, BROMIDE ION, ... | Authors: | Alphey, M.S, Hunter, W.N. | Deposit date: | 2007-06-06 | Release date: | 2007-06-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase Ispe of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis. Chemmedchem, 3, 2008
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5BUR
| O-succinylbenzoate Coenzyme A Synthetase (MenE) from Bacillus Subtilis, in Complex with ATP and Magnesium Ion | Descriptor: | 1,2-ETHANEDIOL, 2-succinylbenzoate--CoA ligase, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Chen, Y, Sun, Y, Song, H, Guo, Z. | Deposit date: | 2015-06-04 | Release date: | 2015-08-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | Structural Basis for the ATP-dependent Configuration of Adenylation Active Site in Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase J.Biol.Chem., 290, 2015
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3ZYO
| Crystal structure of the N-terminal leucine rich repeats and immunoglobulin domain of netrin-G ligand-3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4B, ZINC ION | Authors: | Seiradake, E, Coles, C.H, Perestenko, P.V, Harlos, K, McIlhinney, R.A.J, Aricescu, A.R, Jones, E.Y. | Deposit date: | 2011-08-24 | Release date: | 2011-10-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Basis for Cell Surface Patterning Through Netring-Ngl Interactions. Embo J., 30, 2011
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3ZYN
| Crystal structure of the N-terminal leucine rich repeats of Netrin-G Ligand-3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4B | Authors: | Seiradake, E, Coles, C.H, Perestenko, P.V, Harlos, K, McIlhinney, R.A.J, Aricescu, A.R, Jones, E.Y. | Deposit date: | 2011-08-23 | Release date: | 2011-10-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural Basis for Cell Surface Patterning Through Netring-Ngl Interactions. Embo J., 30, 2011
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3KW4
| Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug ticlopidine | Descriptor: | 2-{[(3alpha,5alpha,7alpha,8alpha,10alpha,12alpha,17alpha)-3,12-bis{2-[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]ethoxy}cholan-7-yl]oxy}ethyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, Cytochrome P450 2B4, ... | Authors: | Gay, S.C, Maekawa, K, Roberts, A.G, Hong, W.-X, Zhang, Q, Stout, C.D, Halpert, J.R. | Deposit date: | 2009-11-30 | Release date: | 2010-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel. Biochemistry, 49, 2010
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5DVF
| Crystal structure of unliganded periplasmic glucose binding protein (ppGBP) from P. putida CSV86 | Descriptor: | Binding protein component of ABC sugar transporter, SULFATE ION | Authors: | Pandey, S, Modak, A, Phale, P.S, Bhaumik, P. | Deposit date: | 2015-09-21 | Release date: | 2016-02-17 | Last modified: | 2016-04-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | High Resolution Structures of Periplasmic Glucose-binding Protein of Pseudomonas putida CSV86 Reveal Structural Basis of Its Substrate Specificity J.Biol.Chem., 291, 2016
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1TXI
| Crystal structure of the vdr ligand binding domain complexed to TX522 | Descriptor: | (1R,3R)-5-((Z)-2-((1R,7AS)-HEXAHYDRO-1-((S)-6-HYDROXY-6-METHYLHEPT-4-YN-2-YL)-7A-METHYL-1H-INDEN-4(7AH)-YLIDENE)ETHYLIDENE)CYCLOHEXANE-1,3-DIOL, Vitamin D receptor | Authors: | Moras, D, Rochel, N. | Deposit date: | 2004-07-05 | Release date: | 2005-05-10 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Superagonistic Action of 14-epi-Analogs of 1,25-Dihydroxyvitamin D Explained by Vitamin D Receptor-Coactivator Interaction Mol.Pharmacol., 67, 2005
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