3UAS
Cytochrome P450 2B4 covalently bound to the mechanism-based inactivator 9-ethynylphenanthrene
Summary for 3UAS
Entry DOI | 10.2210/pdb3uas/pdb |
Descriptor | Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, phenanthren-9-ylacetaldehyde, ... (6 entities in total) |
Functional Keywords | p450, cytochrome p450 2b4, monooxygenase, oxidoreductase, membrane protein, cyp 2b4, cyp lm2 |
Biological source | Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P00178 |
Total number of polymer chains | 1 |
Total formula weight | 55826.84 |
Authors | Gay, S.C.,Zhang, H.,Shah, M.B.,Stout, C.D.,Halpert, J.R.,Hollenberg, P.F. (deposition date: 2011-10-21, release date: 2013-01-09, Last modification date: 2023-09-13) |
Primary citation | Zhang, H.,Gay, S.C.,Shah, M.,Foroozesh, M.,Liu, J.,Osawa, Y.,Zhang, Q.,Stout, C.D.,Halpert, J.R.,Hollenberg, P.F. Potent Mechanism-Based Inactivation of Cytochrome P450 2B4 by 9-Ethynylphenanthrene: Implications for Allosteric Modulation of Cytochrome P450 Catalysis. Biochemistry, 52:355-364, 2013 Cited by PubMed: 23276288DOI: 10.1021/bi301567z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.939 Å) |
Structure validation
Download full validation report