1TXI

Crystal structure of the vdr ligand binding domain complexed to TX522

Summary for 1TXI

• Entry DOI: 10.2210/pdb1txi/pdb
• Related: 1DB1 1IE8 1IE9 1S19 1SOZ
• Descriptor: Vitamin D receptor, (1R,3R)-5-((Z)-2-((1R,7AS)-HEXAHYDRO-1-((S)-6-HYDROXY-6-METHYLHEPT-4-YN-2-YL)-7A-METHYL-1H-INDEN-4(7AH)-YLIDENE)ETHYLIDENE)CYCLOHEXANE-1,3-DIOL (3 entities in total)
• Functional Keywords: vdr ligand binding domain, tx522 complex, nuclear receptor, transcription regulation, alpha-helical sandwich, gene regulation
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 30205.94

Authors

Moras, D.,Rochel, N. (deposition date: 2004-07-05, release date: 2005-05-10, Last modification date: 2024-03-13)

• Primary citation: Eelen, G.,Verlinden, L.,Rochel, N.,Claessens, F.,De Clercq, P.,Vandewalle, M.,Tocchini-Valentini, G.,Moras, D.,Bouillon, R.,Verstuyf, A.; Superagonistic Action of 14-epi-Analogs of 1,25-Dihydroxyvitamin D Explained by Vitamin D Receptor-Coactivator Interaction; Mol.Pharmacol., 67:1566-1573, 2005; PubMed: 15728261; DOI: 10.1124/mol.104.008730

Experimental method

X-RAY DIFFRACTION (1.9 Å)