1TXI
Crystal structure of the vdr ligand binding domain complexed to TX522
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Vitamin D receptor | polymer | 263 | 29805.3 | 1 | UniProt (P11473) Pfam (PF00104) | Homo sapiens (human) | VDR, 1,25-dihydroxyvitamin D3 receptor |
| 2 | B (A) | (1R,3R)-5-((Z)-2-((1R,7AS)-HEXAHYDRO-1-((S)-6-HYDROXY-6-METHYLHEPT-4-YN-2-YL)-7A-METHYL-1H-INDEN-4(7AH)-YLIDENE)ETHYLIDENE)CYCLOHEXANE-1,3-DIOL | non-polymer | 400.6 | 1 | Chemie (TX5) PubChem (21158891) PubChem (59848219) PubChem (53877232) PubChem (73746227) PubChem (90994256) PubChem (5289504) PubChem (9952841) PubChem (11069420) PubChem (6915835) PubChem (122130881) PubChem (10476130) PubChem (10894660) PubChem (146157506) PubChem (131954606) PubChem (134692690) PubChem (134715545) PubChem (156963161) PubChem (162489842) PubChem (171706670) | |||
| 3 | C (A) | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A: 118 - 164 (UniProt: P11473)
A: 216 - 427 (UniProt: P11473)
| PDB | External Database | Details |
|---|---|---|
| Gly 114 | - | cloning artifact |
| Ser 115 | - | cloning artifact |
| His 116 | - | cloning artifact |
| Met 117 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29805.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 400.6 | |
| All* | Total formula weight | 30205.9 |
