8OYW
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8BW1
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![BU of 8bw1 by Molmil](/molmil-images/mine/8bw1) | Yeast 20S proteasome in complex with an engineered fellutamide derivative (C14QAL) | Descriptor: | 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Bozhueyuek, K.A.J, Praeve, L, Kegler, C, Kaiser, S, Shi, Y, Kuttenlochner, W, Schenk, L, Groll, M, Hochberg, G.K.A, Bode, H.B. | Deposit date: | 2022-12-06 | Release date: | 2023-12-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Evolution-inspired engineering of nonribosomal peptide synthetases. Science, 383, 2024
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6DXW
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![BU of 6dxw by Molmil](/molmil-images/mine/6dxw) | Human N-acylethanolamine-hydrolyzing acid amidase (NAAA) precursor (C126A) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gorelik, A, Gebai, A, Illes, K, Piomelli, D, Nagar, B. | Deposit date: | 2018-07-01 | Release date: | 2018-09-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular mechanism of activation of the immunoregulatory amidase NAAA. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6ZWW
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![BU of 6zww by Molmil](/molmil-images/mine/6zww) | Crystal structure of E. coli RNA helicase HrpA in complex with RNA | Descriptor: | ATP-dependent RNA helicase HrpA, CALCIUM ION, ssRNA | Authors: | Grass, L.M, Wollenhaupt, J, Barthel, T, Loll, B, Wahl, M.C. | Deposit date: | 2020-07-29 | Release date: | 2021-06-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.16 Å) | Cite: | Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility. Proc.Natl.Acad.Sci.USA, 118, 2021
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6OPM
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![BU of 6opm by Molmil](/molmil-images/mine/6opm) | Casposase bound to integration product | Descriptor: | CALCIUM ION, CRISPR-associated endonuclease Cas1, DNA 21-mer, ... | Authors: | Dyda, F, Hickman, A.B, Kailasan, S. | Deposit date: | 2019-04-25 | Release date: | 2020-02-12 | Last modified: | 2020-08-26 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas. Elife, 9, 2020
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5K73
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![BU of 5k73 by Molmil](/molmil-images/mine/5k73) | as-isolated Dbr1 with Fe(II) and Zn(II) | Descriptor: | FE (II) ION, HYDROXIDE ION, RNA lariat debranching enzyme, ... | Authors: | Clark, N.E, Taylor, A.B, Hart, P.J. | Deposit date: | 2016-05-25 | Release date: | 2016-12-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | The RNA lariat debranching enzyme Dbr1: metal dependence and branched RNA co-crystal structures Proc.Natl.Acad.Sci.USA, 2016
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5E7Q
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![BU of 5e7q by Molmil](/molmil-images/mine/5e7q) | Acyl-CoA synthetase PtmA2 from Streptomyces platensis | Descriptor: | GLYCEROL, SULFATE ION, acyl-CoA synthetase | Authors: | Osipiuk, J, Cuff, M.E, Hatzos-Skintges, C, Endres, M, Babnigg, G, Rudolf, J, Ma, M, Chang, C.Y, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2015-10-12 | Release date: | 2015-10-21 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme. Nat. Chem. Biol., 14, 2018
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6DYV
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![BU of 6dyv by Molmil](/molmil-images/mine/6dyv) | Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((pent-4-yn-1-ylthio)methyl)pyrrolidin-3-ol | Descriptor: | (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-{[(pent-4-yn-1-yl)sulfanyl]methyl}pyrrolidin-3-ol, 1,2-ETHANEDIOL, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | Authors: | Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L. | Deposit date: | 2018-07-02 | Release date: | 2019-03-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. J. Med. Chem., 62, 2019
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7S2A
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7S2F
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5EAQ
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7S27
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7S2G
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7S29
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7S2C
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7S30
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7S2W
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7S33
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6S20
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![BU of 6s20 by Molmil](/molmil-images/mine/6s20) | Metabolism of multiple glycosaminoglycans by bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (BT33336S-sulf) | Descriptor: | 2-acetamido-2-deoxy-6-O-sulfo-beta-D-galactopyranose, CALCIUM ION, N-acetylgalactosamine-6-O-sulfatase, ... | Authors: | Ndeh, D, Basle, A, Strahl, H, Henrissat, B, Terrapon, N, Cartmell, A. | Deposit date: | 2019-06-19 | Release date: | 2020-02-05 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus. Nat Commun, 11, 2020
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7S28
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7S2B
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7S32
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7S2D
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7S34
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5KDX
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![BU of 5kdx by Molmil](/molmil-images/mine/5kdx) | IMPa metallopeptidase in complex with T-antigen | Descriptor: | 1,2-ETHANEDIOL, Metallopeptidase, PHOSPHATE ION, ... | Authors: | Noach, I, Boraston, A.B. | Deposit date: | 2016-06-08 | Release date: | 2017-01-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Recognition of protein-linked glycans as a determinant of peptidase activity. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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