8BW1
Yeast 20S proteasome in complex with an engineered fellutamide derivative (C14QAL)
Summary for 8BW1
Entry DOI | 10.2210/pdb8bw1/pdb |
Related | 3D29 |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (19 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, proteasome, semisynthesis, inhibitor, binding analysis, hydrolase |
Biological source | Saccharomyces cerevisiae (baker's yeast) More |
Total number of polymer chains | 32 |
Total formula weight | 733530.64 |
Authors | Bozhueyuek, K.A.J.,Praeve, L.,Kegler, C.,Kaiser, S.,Shi, Y.,Kuttenlochner, W.,Schenk, L.,Groll, M.,Hochberg, G.K.A.,Bode, H.B. (deposition date: 2022-12-06, release date: 2023-12-20, Last modification date: 2024-04-03) |
Primary citation | Bozhuyuk, K.A.J.,Prave, L.,Kegler, C.,Schenk, L.,Kaiser, S.,Schelhas, C.,Shi, Y.N.,Kuttenlochner, W.,Schreiber, M.,Kandler, J.,Alanjary, M.,Mohiuddin, T.M.,Groll, M.,Hochberg, G.K.A.,Bode, H.B. Evolution-inspired engineering of nonribosomal peptide synthetases. Science, 383:eadg4320-eadg4320, 2024 Cited by PubMed: 38513038DOI: 10.1126/science.adg4320 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.25 Å) |
Structure validation
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