8BW1

Yeast 20S proteasome in complex with an engineered fellutamide derivative (C14QAL)

Summary for 8BW1

• Entry DOI: 10.2210/pdb8bw1/pdb
• Related: 3D29
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (19 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, proteasome, semisynthesis, inhibitor, binding analysis, hydrolase
• Biological source: Saccharomyces cerevisiae (baker's yeast); More
• Total number of polymer chains: 32
• Total formula weight: 733530.64

Authors

Bozhueyuek, K.A.J.,Praeve, L.,Kegler, C.,Kaiser, S.,Shi, Y.,Kuttenlochner, W.,Schenk, L.,Groll, M.,Hochberg, G.K.A.,Bode, H.B. (deposition date: 2022-12-06, release date: 2023-12-20, Last modification date: 2024-04-03)

• Primary citation: Bozhuyuk, K.A.J.,Prave, L.,Kegler, C.,Schenk, L.,Kaiser, S.,Schelhas, C.,Shi, Y.N.,Kuttenlochner, W.,Schreiber, M.,Kandler, J.,Alanjary, M.,Mohiuddin, T.M.,Groll, M.,Hochberg, G.K.A.,Bode, H.B.; Evolution-inspired engineering of nonribosomal peptide synthetases.; Science, 383:eadg4320-eadg4320, 2024; PubMed: 38513038; DOI: 10.1126/science.adg4320

Experimental method

X-RAY DIFFRACTION (3.25 Å)