4EDS
 
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4ETX
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4EU9
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4EUV
 | | Crystal Structure of PelD 158-CT from Pseudomonas aeruginosa PAO1, in complex with c-di-GMP, form 1 | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), PelD | | Authors: | Li, Z, Chen, J, Nair, S.K. | | Deposit date: | 2012-04-25 | | Release date: | 2012-07-25 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structures of the PelD Cyclic Diguanylate Effector Involved in Pellicle Formation in Pseudomonas aeruginosa PAO1.
J.Biol.Chem., 287, 2012
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4EWH
 | | Co-crystal structure of ACK1 with inhibitor | | Descriptor: | 6-{4-[2-(dimethylamino)ethoxy]phenyl}-N-(1,3-dithiolan-2-ylmethyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Activated CDC42 kinase 1 | | Authors: | Liu, J, Walker, N, Wang, Z. | | Deposit date: | 2012-04-27 | | Release date: | 2012-09-19 | | Last modified: | 2012-10-31 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
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4EDT
 | | The structure of the S. aureus DnaG RNA Polymerase Domain bound to ppGpp and Manganese | | Descriptor: | BENZAMIDINE, DNA primase, GUANOSINE-5',3'-TETRAPHOSPHATE, ... | | Authors: | Rymer, R.U, Solorio, F.A, Chu, C, Corn, J.E, Wang, J.D, Berger, J.M. | | Deposit date: | 2012-03-27 | | Release date: | 2012-07-25 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.005 Å) | | Cite: | Binding Mechanism of Metal-NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases.
Structure, 20, 2012
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4EQG
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4EL2
 | | Initial Thaumatin Structure for Radiation Damage Experiment at 240 K | | Descriptor: | L(+)-TARTARIC ACID, Thaumatin-1 | | Authors: | Warkentin, M, Badeau, R, Hopkins, J.B, Thorne, R.E. | | Deposit date: | 2012-04-10 | | Release date: | 2012-08-29 | | Last modified: | 2013-01-23 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Spatial distribution of radiation damage to crystalline proteins at 25-300 K.
Acta Crystallogr.,Sect.D, 68, 2012
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4EUA
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4EN4
 | | Crystal Structure of the Ternary Human PL Kinase-Ginkgotoxin-MgATP Complex | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-(hydroxymethyl)-4-(methoxymethyl)-2-methylpyridin-3-ol, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Safo, M.K, Musayev, F.N, Gandhi, A.K. | | Deposit date: | 2012-04-12 | | Release date: | 2012-05-02 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: insights into pyridoxal kinase inhibition.
Plos One, 7, 2012
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4ENW
 | | Structure of the S234N variant of E. coli KatE | | Descriptor: | CIS-HEME D HYDROXYCHLORIN GAMMA-SPIROLACTONE, Catalase HPII | | Authors: | Loewen, P.C, Jha, V. | | Deposit date: | 2012-04-13 | | Release date: | 2012-05-02 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Influence of main channel structure on H(2)O(2) access to the heme cavity of catalase KatE of Escherichia coli.
Arch.Biochem.Biophys., 526, 2012
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4EP1
 | | Crystal structure of anabolic ornithine carbamoyltransferase from Bacillus anthracis | | Descriptor: | Ornithine carbamoyltransferase | | Authors: | Shabalin, I.G, Mikolajczak, K, Stam, J, Winsor, J, Shuvalova, L, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2012-04-16 | | Release date: | 2012-04-25 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | Crystal structures of anabolic ornithine carbamoyltransferase from Bacillus anthracis
To be Published
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4EPJ
 | | Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate p2-NC | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, BETA-MERCAPTOETHANOL, ... | | Authors: | Schiffer, C.A, Mittal, S. | | Deposit date: | 2012-04-17 | | Release date: | 2012-06-06 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease.
Protein Sci., 21, 2012
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4ESX
 | | Crystal structure of C. albicans Thi5 complexed with PLP | | Descriptor: | Pyrimidine biosynthesis enzyme THI13 | | Authors: | Huang, S, Fenwick, M.K, Zhang, Y, Lai, R, Hazra, A, Rajashankar, K, Philmus, B, Kinsland, C, Sanders, J, Begley, T.P, Ealick, S.E. | | Deposit date: | 2012-04-23 | | Release date: | 2012-09-19 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Thiamin pyrimidine biosynthesis in Candida albicans : a remarkable reaction between histidine and pyridoxal phosphate.
J.Am.Chem.Soc., 134, 2012
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4EY6
 | | Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with (-)-galantamine | | Descriptor: | (-)-GALANTHAMINE, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Cheung, J, Rudolph, M, Burshteyn, F, Cassidy, M, Gary, E, Love, J, Height, J, Franklin, M. | | Deposit date: | 2012-05-01 | | Release date: | 2012-10-17 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.3983 Å) | | Cite: | Structures of human acetylcholinesterase in complex with pharmacologically important ligands.
J.Med.Chem., 55, 2012
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4E5F
 | | Crystal structure of avian influenza virus PAn bound to compound 1 | | Descriptor: | 2-hydroxyisoquinoline-1,3(2H,4H)-dione, MANGANESE (II) ION, Polymerase protein PA, ... | | Authors: | DuBois, R.M, Slavish, P.J, Webb, T.R, White, S.W. | | Deposit date: | 2012-03-14 | | Release date: | 2012-08-08 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.392 Å) | | Cite: | Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease.
Plos Pathog., 8, 2012
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4E6Y
 | | Type II citrate synthase from Vibrio vulnificus. | | Descriptor: | Citrate synthase, FORMIC ACID | | Authors: | Osipiuk, J, Gu, M, Kwon, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2012-03-16 | | Release date: | 2012-03-28 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Type II citrate synthase from Vibrio vulnificus.
To be Published
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4EAJ
 | | Co-crystal of AMPK core with AMP soaked with ATP | | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... | | Authors: | Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W. | | Deposit date: | 2012-03-22 | | Release date: | 2012-06-06 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.609 Å) | | Cite: | AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
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4EDO
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4EEV
 | | Crystal structure of c-Met in complex with LY2801653 | | Descriptor: | Hepatocyte growth factor receptor, N-(3-fluoro-4-{[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide | | Authors: | Wang, Y, Stout, S.L. | | Deposit date: | 2012-03-28 | | Release date: | 2013-04-10 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models.
Invest New Drugs, 31, 2013
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4EFZ
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4EKT
 | | Final Thaumatin Structure for Radiation Damage Experiment at 180 K | | Descriptor: | L(+)-TARTARIC ACID, Thaumatin-1 | | Authors: | Warkentin, M, Badeau, R, Hopkins, J.B, Thorne, R.E. | | Deposit date: | 2012-04-09 | | Release date: | 2012-08-29 | | Last modified: | 2013-01-23 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Spatial distribution of radiation damage to crystalline proteins at 25-300 K.
Acta Crystallogr.,Sect.D, 68, 2012
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4EL3
 | | Final Thaumatin Structure for Radiation Damage Experiment at 240 K | | Descriptor: | L(+)-TARTARIC ACID, Thaumatin-1 | | Authors: | Warkentin, M, Badeau, R, Hopkins, J.B, Thorne, R.E. | | Deposit date: | 2012-04-10 | | Release date: | 2012-08-29 | | Last modified: | 2013-01-23 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Spatial distribution of radiation damage to crystalline proteins at 25-300 K.
Acta Crystallogr.,Sect.D, 68, 2012
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4EKS
 | | T4 Lysozyme L99A/M102H with Isoxazole Bound | | Descriptor: | 1,2-benzisoxazole, 2-HYDROXYETHYL DISULFIDE, ACETATE ION, ... | | Authors: | Merski, M, Shoichet, B.K. | | Deposit date: | 2012-04-09 | | Release date: | 2012-09-05 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Engineering a model protein cavity to catalyze the Kemp elimination.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4EL7
 | | Initial Thaumatin Structure for Radiation Damage Experiment at 300 K | | Descriptor: | L(+)-TARTARIC ACID, Thaumatin-1 | | Authors: | Warkentin, M, Badeau, R, Hopkins, J.B, Thorne, R.E. | | Deposit date: | 2012-04-10 | | Release date: | 2012-08-29 | | Last modified: | 2013-01-23 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Spatial distribution of radiation damage to crystalline proteins at 25-300 K.
Acta Crystallogr.,Sect.D, 68, 2012
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