4EY6
Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with (-)-galantamine
Summary for 4EY6
Entry DOI | 10.2210/pdb4ey6/pdb |
Descriptor | Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, (-)-GALANTHAMINE, ... (8 entities in total) |
Functional Keywords | acetylcholinesterase, hydrolase, galantamine, inhibitor, galanthamine, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 121511.86 |
Authors | Cheung, J.,Rudolph, M.,Burshteyn, F.,Cassidy, M.,Gary, E.,Love, J.,Height, J.,Franklin, M. (deposition date: 2012-05-01, release date: 2012-10-17, Last modification date: 2023-09-13) |
Primary citation | Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.S.,Gary, E.N.,Love, J.,Franklin, M.C.,Height, J.J. Structures of human acetylcholinesterase in complex with pharmacologically important ligands. J.Med.Chem., 55:10282-10286, 2012 Cited by PubMed: 23035744DOI: 10.1021/jm300871x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3983 Å) |
Structure validation
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