PDB: 1396 resultsInfo pagesStatus searchChemie searchBIRD

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1E6G	A-SPECTRIN SH3 DOMAIN A11V, V23L, M25I, V53I, V58L MUTANT Descriptor: SPECTRIN ALPHA CHAIN, SULFATE ION Authors: Vega, M.C, Serrano, L. Deposit date: 2000-08-15 Release date: 2002-05-23 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Conformational Strain in the Hydrophobic Core and its Implications for Protein Folding and Design Nat.Struct.Biol., 9, 2002
8WE6	Human L-type voltage-gated calcium channel Cav1.2 at 2.9 Angstrom resolution Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Gao, S, Yao, X, Yan, N. Deposit date: 2023-09-17 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
9CEQ	Lanthanide Binding Tag complex LBT3-NH2:La3+ Descriptor: LANTHANUM (III) ION, Lanthanide Binding Tag Peptide Authors: Kt, S, Messinger, R.J, Favaro, D.C. Deposit date: 2024-06-27 Release date: 2024-07-17 Method: SOLUTION NMR Cite: Role of Water in the Selective Complexation of Rare Earth Elements by Lanthanide Binding Tag Peptides To Be Published
9B91	Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium and ATP at 37 degrees Celsius Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Transient receptor potential cation channel subfamily M member 4 Authors: Hu, J, Lu, W, Du, J. Deposit date: 2024-04-01 Release date: 2024-05-15 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Physiological temperature drives TRPM4 ligand recognition and gating. Nature, 630, 2024
9B90	Cryo-EM structure of the human TRPM4 channel in complex with calcium and ATP at 37 degrees Celsius Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Transient receptor potential cation channel subfamily M member 4 Authors: Hu, J, Lu, W, Du, J. Deposit date: 2024-04-01 Release date: 2024-05-15 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Physiological temperature drives TRPM4 ligand recognition and gating. Nature, 630, 2024
8UQO	PLCb3-Gbg-Gaq complex on membranes Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Falzone, M.E, MacKinnon, R. Deposit date: 2023-10-24 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (3.37 Å) Cite: The mechanism of G alpha q regulation of PLC beta 3 -catalyzed PIP2 hydrolysis. Proc.Natl.Acad.Sci.USA, 120, 2023
8WEA	Human L-type voltage-gated calcium channel Cav1.2 (Class II) in the presence of pinaverium at 3.2 Angstrom resolution Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Gao, S, Yao, X, Fan, X, Yan, N. Deposit date: 2023-09-17 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
9B93	Cryo-EM structure of the human TRPM4 channel in the presence of EDTA at 37 degrees Celsius Descriptor: Transient receptor potential cation channel subfamily M member 4 Authors: Hu, J, Lu, W, Du, J. Deposit date: 2024-04-01 Release date: 2024-05-15 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Physiological temperature drives TRPM4 ligand recognition and gating. Nature, 630, 2024
8WE9	Human L-type voltage-gated calcium channel Cav1.2 (Class I) in the presence of pinaverium at 3.0 Angstrom resolution Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Gao, S, Yao, X, Fan, X, Yan, N. Deposit date: 2023-09-17 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
8WE8	Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine, amlodipine and pinaverium at 2.9 Angstrom resolution Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Gao, S, Yao, X, Yan, N. Deposit date: 2023-09-17 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
9B8Z	Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium and decavanadate at 37 degrees Celsius Descriptor: CALCIUM ION, DECAVANADATE, Transient receptor potential cation channel subfamily M member 4 Authors: Hu, J, Lu, W, Du, J. Deposit date: 2024-04-01 Release date: 2024-05-15 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Physiological temperature drives TRPM4 ligand recognition and gating. Nature, 630, 2024
8WE7	Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine at 3.2 Angstrom resolution Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Gao, S, Yao, X, Yan, N. Deposit date: 2023-09-17 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
8UQN	PLCb3-Gaq complex on membranes Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Falzone, M.E, MacKinnon, R. Deposit date: 2023-10-24 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: The mechanism of G alpha q regulation of PLC beta 3 -catalyzed PIP2 hydrolysis. Proc.Natl.Acad.Sci.USA, 120, 2023
8VJK	Structure of mouse RyR1 (high-Ca2+/CFF/ATP dataset) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, ... Authors: Weninger, G, Marks, A.R. Deposit date: 2024-01-07 Release date: 2024-01-17 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (2.92 Å) Cite: Structural insights into the regulation of RyR1 by S100A1. Proc.Natl.Acad.Sci.USA, 121, 2024
9B92	Cryo-EM structure of the human TRPM4 in complex with calcium at 18 degrees Celsius Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 4 Authors: Hu, J, Lu, W, Du, J. Deposit date: 2024-04-01 Release date: 2024-05-15 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Physiological temperature drives TRPM4 ligand recognition and gating. Nature, 630, 2024
9B8W	Cryo-EM structure of the human TRPM4 in complex with calcium at 37 degrees Celsius Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 4 Authors: Hu, J, Lu, W, Du, J. Deposit date: 2024-04-01 Release date: 2024-05-15 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Physiological temperature drives TRPM4 ligand recognition and gating. Nature, 630, 2024
8VK3	Structure of mouse RyR1 in complex with S100A1 (EGTA-only dataset) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Peptidyl-prolyl cis-trans isomerase FKBP1A, Protein S100A1, ... Authors: Weninger, G, Marks, A.R. Deposit date: 2024-01-08 Release date: 2024-01-24 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (3.21 Å) Cite: Structural insights into the regulation of RyR1 by S100A1. Proc.Natl.Acad.Sci.USA, 121, 2024
9B8X	Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium 37 degrees Celsius Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 4 Authors: Hu, J, Lu, W, Du, J. Deposit date: 2024-04-01 Release date: 2024-05-15 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3 Å) Cite: Physiological temperature drives TRPM4 ligand recognition and gating. Nature, 630, 2024
9B8Y	Cryo-EM structure of the human TRPM4 channel in complex with calcium and decavanadate at 37 degrees Celsius Descriptor: CALCIUM ION, DECAVANADATE, Transient receptor potential cation channel subfamily M member 4 Authors: Hu, J, Lu, W, Du, J. Deposit date: 2024-04-01 Release date: 2024-05-15 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Physiological temperature drives TRPM4 ligand recognition and gating. Nature, 630, 2024
8VJJ	Structure of mouse RyR1 (EGTA-only dataset) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Peptidyl-prolyl cis-trans isomerase FKBP1A, Ryanodine receptor 1, ... Authors: Weninger, G, Marks, A.R. Deposit date: 2024-01-07 Release date: 2024-01-17 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (2.53 Å) Cite: Structural insights into the regulation of RyR1 by S100A1. Proc.Natl.Acad.Sci.USA, 121, 2024
8VK4	Structure of mouse RyR1 in complex with S100A1 (high-Ca2+/CFF/ATP dataset) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, ... Authors: Weninger, G, Marks, A.R. Deposit date: 2024-01-08 Release date: 2024-02-07 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (3.56 Å) Cite: Structural insights into the regulation of RyR1 by S100A1. Proc.Natl.Acad.Sci.USA, 121, 2024
8UXE	Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 Descriptor: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.53 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXC	Structure of PKA phosphorylated human RyR2-R420Q in the primed state Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXG	Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 Descriptor: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.08 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXH	Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published

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