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1NZV	Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYIpYVPA Descriptor: CHLORIDE ION, Doubly phosphorylated peptide PQpYIpYVPA, TETRAETHYLENE GLYCOL, ... Authors: Lubman, O.Y, Waksman, G. Deposit date: 2003-02-19 Release date: 2003-04-22 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and Thermodynamic Basis for the Interaction of the Src SH2 domain with the Activated form of the PDGF beta-receptor J.Mol.Biol., 328, 2003
1NZL	Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYEpYIPI Descriptor: CHLORIDE ION, Doubly phosphorylated peptide ligand (PQpYEpYIPI), TETRAETHYLENE GLYCOL, ... Authors: Lubman, O.Y, Waksman, G. Deposit date: 2003-02-18 Release date: 2003-04-22 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and Thermodynamic Basis for the Interaction of the Src SH2 domain with the Activated form of the PDGF beta-receptor J.Mol.Biol., 328, 2003
1M27	Crystal structure of SAP/FynSH3/SLAM ternary complex Descriptor: CITRATE ANION, Proto-oncogene tyrosine-protein kinase FYN, SH2 domain protein 1A, ... Authors: Chan, B, Griesbach, J, Song, H.K, Poy, F, Terhorst, C, Eck, M.J. Deposit date: 2002-06-21 Release date: 2003-05-06 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: SAP couples Fyn to SLAM immune receptors. NAT.CELL BIOL., 5, 2003
1M61	Crystal structure of the apo SH2 domains of ZAP-70 Descriptor: PHOSPHATE ION, TYROSINE-PROTEIN KINASE ZAP-70 Authors: Folmer, R.H.A, Geschwindner, S, Xue, Y. Deposit date: 2002-07-11 Release date: 2003-07-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem Biochemistry, 41, 2002
1P13	Crystal Structure of the Src SH2 Domain Complexed with Peptide (SDpYANFK) Descriptor: CACODYLATE ION, Peptide, Proto-oncogene tyrosine-protein kinase Src Authors: Sonnenburg, E.D, Bilwes, A, Hunter, T, Noel, J.P. Deposit date: 2003-04-11 Release date: 2003-08-19 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.63 Å) Cite: The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region. Biochemistry, 42, 2003
1MW4	Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139 Descriptor: Growth factor receptor-bound protein 7, Receptor protein-tyrosine kinase erbB-2 Authors: Ivancic, M, Lyons, B.A. Deposit date: 2002-09-27 Release date: 2003-09-09 Last modified: 2012-05-02 Method: SOLUTION NMR Cite: Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2 J.BIOMOL.NMR, 27, 2003
1RPY	CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS Descriptor: SULFATE ION, adaptor protein APS Authors: Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R. Deposit date: 2003-12-03 Release date: 2003-12-23 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol.Cell, 12, 2003
1RQQ	Crystal Structure of the Insulin Receptor Kinase in Complex with the SH2 Domain of APS Descriptor: BISUBSTRATE INHIBITOR, Insulin receptor, MANGANESE (II) ION, ... Authors: Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R. Deposit date: 2003-12-06 Release date: 2003-12-30 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol.Cell, 12, 2003
1O4J	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH ISO24. Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, [(4-ETHYLPHENYL)AMINO]CARBONYLPHOSPHONIC ACID Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4D	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78262. Descriptor: 2-FORMYLPHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4H	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79072. Descriptor: 2-CYANOQUINOLIN-8-YL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4L	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH FRAGMENT2. Descriptor: CITRIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O43	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82129. Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, [4-((1Z)-2-(ACETYLAMINO)-3-{[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]AMINO}-3-OXOPROP-1-ENYL)-2-FORMYLPHENYL]ACET IC ACID Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O49	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85493. Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, {4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-PHOSPHONO-PHENOXY}-ACETIC ACID Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4G	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH DPI59. Descriptor: HYDROXY(1-NAPHTHYL)METHYLPHOSPHONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4M	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH MALONICACID. Descriptor: MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O45	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU84687. Descriptor: N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-3-FORMYL-O-PHOSPHONOTYROSINAMIDE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4F	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79073. Descriptor: 1,2,3,4-TETRAHYDROQUINOLIN-8-YL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4K	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PASBN. Descriptor: BENZYL 2-FORMYLPHENYL HYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4A	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82197. Descriptor: 4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-FORMYL-BENZOIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O44	Crystal structure of sh2 in complex with ru85052 Descriptor: 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXY-PHENYL}-MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4C	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHOSPHATE. Descriptor: PHOSPHATE ION, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4I	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PAS219. Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, cyclohexylmethyl 2-formylphenyl hydrogen (S)-phosphate Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O48	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85053. Descriptor: 5-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXYMETHYL-BENZOIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4O	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHENYLPHOSPHATE. Descriptor: PHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003

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