1O4C

CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHOSPHATE.

Summary for 1O4C

DescriptorPROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, PHOSPHATE ION (3 entities in total)
Functional Keywordssh2 domain fragment approach, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCell membrane P12931
Total number of polymer chains1
Total molecular weight12485.94
Authors
Lange, G.,Loenze, P.,Liesum, A. (deposition date: 2003-06-15, release date: 2004-02-17, Last modification date: 2011-07-13)
Primary citation
Lange, G.,Lesuisse, D.,Deprez, P.,Schoot, B.,Loenze, P.,Benard, D.,Marquette, J.P.,Broto, P.,Sarubbi, E.,Mandine, E.
Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46:5184-5195, 2003
PubMed: 14613321 (PDB entries with the same primary citation)
DOI: 10.1021/jm020970s
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers40 7.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
170172
PDB entries from 2020-10-21