8BL8
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![BU of 8bl8 by Molmil](/molmil-images/mine/8bl8) | Human serotonin 5-HT3A receptor (apo, active/distorted conformation) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A | Authors: | Lopez-Sanchez, U, Nury, H. | Deposit date: | 2022-11-09 | Release date: | 2024-05-15 | Last modified: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors. Nat.Struct.Mol.Biol., 31, 2024
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8OYI
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![BU of 8oyi by Molmil](/molmil-images/mine/8oyi) | particulate methane monooxygenase with 2,2,2-trifluoroethanol bound | Descriptor: | 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-dihexanoyl-sn-glycero-3-phosphocholine, Ammonia monooxygenase/methane monooxygenase, ... | Authors: | Tucci, F.J, Rosenzweig, A.C. | Deposit date: | 2023-05-04 | Release date: | 2023-11-08 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.19 Å) | Cite: | Product analog binding identifies the copper active site of particulate methane monooxygenase. Nat Catal, 6, 2023
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8BLB
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![BU of 8blb by Molmil](/molmil-images/mine/8blb) | Human serotonin 5-HT3A receptor in complex with vortioxetine (nanodiscs, ECD, active/distorted conformation) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | Authors: | Lopez-Sanchez, U, Nury, H. | Deposit date: | 2022-11-09 | Release date: | 2024-05-15 | Last modified: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors. Nat.Struct.Mol.Biol., 31, 2024
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8OUJ
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![BU of 8ouj by Molmil](/molmil-images/mine/8ouj) | Heterotrimeric Complex of Human ASCT2 with Syncytin-1 | Descriptor: | ALANINE, Neutral amino acid transporter B(0), Syncytin-1 | Authors: | Khare, S, Reyes, N. | Deposit date: | 2023-04-23 | Release date: | 2024-05-01 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Receptor-recognition and antiviral mechanisms of retrovirus-derived human proteins. Nat.Struct.Mol.Biol., 2024
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8OUI
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![BU of 8oui by Molmil](/molmil-images/mine/8oui) | Complex of ASCT2 with Suppressyn | Descriptor: | ALANINE, Neutral amino acid transporter B(0), Suppressyn | Authors: | Khare, S, Kumar, A, Reyes, N. | Deposit date: | 2023-04-23 | Release date: | 2024-05-01 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Receptor-recognition and antiviral mechanisms of retrovirus-derived human proteins. Nat.Struct.Mol.Biol., 2024
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8CQR
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![BU of 8cqr by Molmil](/molmil-images/mine/8cqr) | |
7YN9
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![BU of 7yn9 by Molmil](/molmil-images/mine/7yn9) | Cryo-EM structure of Cas7-11-crRNA binary complex | Descriptor: | CRISPR-associated RAMP family protein, crRNA | Authors: | Huo, Y, Dong, Q, Zhao, H, Jiang, T. | Deposit date: | 2022-07-30 | Release date: | 2023-02-01 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector. Nat Microbiol, 8, 2023
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7YNC
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![BU of 7ync by Molmil](/molmil-images/mine/7ync) | Cryo-EM structure of Cas7-11-crRNA bound to target RNA-3 | Descriptor: | CRISPR-associated RAMP family protein, Target RNA-3 (28-MER), crRNA (38-MER) | Authors: | Huo, Y, Dong, Q, Zhao, H, Jiang, T. | Deposit date: | 2022-07-30 | Release date: | 2023-02-01 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector. Nat Microbiol, 8, 2023
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7YNA
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![BU of 7yna by Molmil](/molmil-images/mine/7yna) | Cryo-EM structure of Cas7-11-crRNA bound to target RNA-1 | Descriptor: | CRISPR-associated RAMP family protein, Target RNA-1 (25-MER), crRNA (38-MER) | Authors: | Huo, Y, Dong, Q, Zhao, H, Jiang, T. | Deposit date: | 2022-07-30 | Release date: | 2023-02-01 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector. Nat Microbiol, 8, 2023
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7YNB
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![BU of 7ynb by Molmil](/molmil-images/mine/7ynb) | Cryo-EM structure of Cas7-11-crRNA bound to target RNA-2 | Descriptor: | CRISPR-associated RAMP family protein, Target RNA-2 (28-MER), crRNA (38-MER) | Authors: | Huo, Y, Dong, Q, Zhao, H, Jiang, T. | Deposit date: | 2022-07-30 | Release date: | 2023-02-01 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector. Nat Microbiol, 8, 2023
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7YND
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![BU of 7ynd by Molmil](/molmil-images/mine/7ynd) | Cryo-EM structure of Cas7-11-crRNA-Csx29 ternary complex | Descriptor: | CHAT domain-containing protein, CRISPR-associated RAMP family protein, crRNA (38-MER) | Authors: | Huo, Y, Dong, Q, Zhao, H, Jiang, T. | Deposit date: | 2022-07-30 | Release date: | 2023-02-01 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector. Nat Microbiol, 8, 2023
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2M19
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![BU of 2m19 by Molmil](/molmil-images/mine/2m19) | Solution structure of the Haloferax volcanii HVO 2177 protein | Descriptor: | Molybdopterin converting factor subunit 1 | Authors: | Li, Y, Maciejewski, M.W, Martin, J, Jin, K, Zhang, Y, Lu, M, Maupin-Furlow, J.A, Hao, B. | Deposit date: | 2012-11-21 | Release date: | 2013-08-07 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Crystal structure of the ubiquitin-like small archaeal modifier protein 2 from Haloferax volcanii. Protein Sci., 22, 2013
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8PPU
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![BU of 8ppu by Molmil](/molmil-images/mine/8ppu) | Pyrococcus abyssi DNA polymerase D (PolD) in its editing mode bound to a primer/template substrate containing three consecutive mismatches | Descriptor: | DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*(GS)P*(C7R)P*(PST)P*(PST)P*(PST))-3'), DNA polymerase II small subunit, ... | Authors: | Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. | Deposit date: | 2023-07-10 | Release date: | 2023-12-20 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023
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8PPV
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![BU of 8ppv by Molmil](/molmil-images/mine/8ppv) | Intermediate conformer of Pyrococcus abyssi DNA polymerase D (PolD) bound to a primer/template substrate containing three consecutive mismatches | Descriptor: | DNA (5'-D(*P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*(GS)P*(G7P)P*(PST)P*(PST)P*(PST))-3'), DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA polymerase II small subunit, ... | Authors: | Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. | Deposit date: | 2023-07-10 | Release date: | 2023-12-20 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023
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8PPT
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![BU of 8ppt by Molmil](/molmil-images/mine/8ppt) | Pyrococcus abyssi DNA polymerase D (PolD) in its editing mode bound to a primer/template substrate containing a mismatch | Descriptor: | DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*GP*CP*TP*TP*T)-3'), DNA polymerase II small subunit, ... | Authors: | Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. | Deposit date: | 2023-07-10 | Release date: | 2023-12-20 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023
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8PD0
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![BU of 8pd0 by Molmil](/molmil-images/mine/8pd0) | cryo-EM structure of Doa10 in MSP1E3D1 | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, ERAD-associated E3 ubiquitin-protein ligase DOA10 | Authors: | Botsch, J.J, Braeuning, B, Schulman, B.A. | Deposit date: | 2023-06-11 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE. Nat Commun, 15, 2024
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8PDA
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![BU of 8pda by Molmil](/molmil-images/mine/8pda) | cryo-EM structure of Doa10 with RING domain in MSP1E3D1 | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, ERAD-associated E3 ubiquitin-protein ligase DOA10 | Authors: | Botsch, J.J, Braeuning, B, Schulman, B.A. | Deposit date: | 2023-06-12 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE. Nat Commun, 15, 2024
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4Q30
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![BU of 4q30 by Molmil](/molmil-images/mine/4q30) | Nitrowillardiine bound to the ligand binding domain of GluA2 at pH 3.5 | Descriptor: | 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2 CHIMERIC PROTEIN, ZINC ION | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2014-04-10 | Release date: | 2014-06-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Thermodynamics and mechanism of the interaction of willardiine partial agonists with a glutamate receptor: implications for drug development. Biochemistry, 53, 2014
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6J9E
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![BU of 6j9e by Molmil](/molmil-images/mine/6j9e) | |
7ZJE
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![BU of 7zje by Molmil](/molmil-images/mine/7zje) | C16-2 | Descriptor: | Transient receptor potential cation channel subfamily V member 2,Enhanced green fluorescent protein | Authors: | Zhang, L, Gourdon, P, Zygmunt, P.M. | Deposit date: | 2022-04-10 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function. Nat Commun, 13, 2022
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7ZJG
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![BU of 7zjg by Molmil](/molmil-images/mine/7zjg) | Probenecid | Descriptor: | Transient receptor potential cation channel subfamily V member 2 | Authors: | Zhang, L, Gourdon, P, Zygmunt, P.M. | Deposit date: | 2022-04-11 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function. Nat Commun, 13, 2022
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7ZJI
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![BU of 7zji by Molmil](/molmil-images/mine/7zji) | |
7ZJH
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![BU of 7zjh by Molmil](/molmil-images/mine/7zjh) | TRPV2-C16+Pro-2 | Descriptor: | Transient receptor potential cation channel subfamily V member 2 | Authors: | Zhang, L, Gourdon, P, Zygmunt, P.M. | Deposit date: | 2022-04-11 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function. Nat Commun, 13, 2022
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7ZJD
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![BU of 7zjd by Molmil](/molmil-images/mine/7zjd) | |
7QPM
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![BU of 7qpm by Molmil](/molmil-images/mine/7qpm) | Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate | Descriptor: | 5,7-dimethyl-2-[(1-methyl-4-phenyl-imidazol-2-yl)sulfanylmethyl]imidazo[1,2-a]pyrimidine, MAGNESIUM ION, ZINC ION, ... | Authors: | Leonard, P.M, Langgard, M. | Deposit date: | 2022-01-05 | Release date: | 2023-04-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate To Be Published
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