8REV
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8VQ4
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![BU of 8vq4 by Molmil](/molmil-images/mine/8vq4) | CDK2-CyclinE1 in complex with allosteric inhibitor I-125A. | Descriptor: | (8R)-6-(1-benzyl-1H-pyrazole-4-carbonyl)-N-[(2S,3R)-3-(2-cyclohexylethoxy)-1-(methylamino)-1-oxobutan-2-yl]-2-[(1S)-2,2-dimethylcyclopropane-1-carbonyl]-2,6-diazaspiro[3.4]octane-8-carboxamide, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 | Authors: | Hirschi, M, Johnson, E, Zhang, Y, Liu, Z, Brodsky, O, Won, S.J, Nagata, A, Petroski, M.D, Majmudar, J.D, Niessen, S, VanArsdale, T, Gilbert, A.M, Hayward, M.M, Stewart, A.E, Nager, A.R, Melillo, B, Cravatt, B. | Deposit date: | 2024-01-17 | Release date: | 2024-01-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Expanding the ligandable proteome by paralog hopping with covalent probes. Biorxiv, 2024
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1RDQ
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![BU of 1rdq by Molmil](/molmil-images/mine/1rdq) | Hydrolysis of ATP in the crystal of Y204A mutant of cAMP-dependent protein kinase | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Yang, J, Ten Eyck, L.F, Xuong, N.H, Taylor, S.S. | Deposit date: | 2003-11-05 | Release date: | 2004-04-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.26 Å) | Cite: | Crystal Structure of a cAMP-dependent Protein Kinase Mutant at 1.26A: New Insights into the Catalytic Mechanism. J.Mol.Biol., 336, 2004
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8VQ3
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![BU of 8vq3 by Molmil](/molmil-images/mine/8vq3) | CDK2-CyclinE1 in complex with allosteric inhibitor I-198. | Descriptor: | (8R)-N-[(2S,3R)-3-(cyclohexylmethoxy)-1-(morpholin-4-yl)-1-oxobutan-2-yl]-2-[(1S)-2,2-dimethylcyclopropane-1-carbonyl]-6-(1,3-thiazole-5-carbonyl)-2,6-diazaspiro[3.4]octane-8-carboxamide, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 | Authors: | Hirschi, M, Johnson, E, Zhang, Y, Liu, Z, Brodsky, O, Won, S.J, Nagata, A, Petroski, M.D, Majmudar, J.D, Niessen, S, VanArsdale, T, Gilbert, A.M, Hayward, M.M, Stewart, A.E, Nager, A.R, Melillo, B, Cravatt, B. | Deposit date: | 2024-01-17 | Release date: | 2024-01-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Expanding the ligandable proteome by paralog hopping with covalent probes. Biorxiv, 2024
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8UV0
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1I8G
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![BU of 1i8g by Molmil](/molmil-images/mine/1i8g) | SOLUTION STRUCTURE OF PIN1 WW DOMAIN COMPLEXED WITH CDC25 PHOSPHOTHREONINE PEPTIDE | Descriptor: | M-PHASE INDUCER PHOSPHATASE 3, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1 | Authors: | Wintjens, R, Wieruszeski, J.-M, Drobecq, H, Lippens, G, Landrieu, I. | Deposit date: | 2001-03-14 | Release date: | 2001-07-18 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | 1H NMR study on the binding of Pin1 Trp-Trp domain with phosphothreonine peptides. J.Biol.Chem., 276, 2001
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1IX4
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![BU of 1ix4 by Molmil](/molmil-images/mine/1ix4) | Crystal Structure of Rat Heme Oxygenase-1 in complex with Heme bound to Carbon Monoxide | Descriptor: | CARBON MONOXIDE, HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Sugishima, M, Sakamoto, H, Omata, Y, Hayashi, S, Noguchi, M, Fukuyama, K. | Deposit date: | 2002-06-10 | Release date: | 2003-09-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structures of Ferrous and CO-, CN(-)-, and NO-Bound Forms of Rat Heme Oxygenase-1 (HO-1) in Complex with Heme: Structural Implications for Discrimination between CO and O(2) in HO-1. Biochemistry, 42, 2003
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8URV
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6GVQ
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1IX3
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![BU of 1ix3 by Molmil](/molmil-images/mine/1ix3) | Crystal Structure of Rat Heme Oxygenase-1 in complex with Heme bound to Cyanide | Descriptor: | CYANIDE ION, HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Sugishima, M, Sakamoto, H, Omata, Y, Hayashi, S, Noguchi, M, Fukuyama, K. | Deposit date: | 2002-06-10 | Release date: | 2003-09-02 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structures of Ferrous and CO-, CN(-)-, and NO-Bound Forms of Rat Heme Oxygenase-1 (HO-1) in Complex with Heme: Structural Implications for Discrimination between CO and O(2) in HO-1. Biochemistry, 42, 2003
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1J1L
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![BU of 1j1l by Molmil](/molmil-images/mine/1j1l) | Crystal structure of human Pirin: a Bcl-3 and Nuclear factor I interacting protein and a cupin superfamily member | Descriptor: | FE (II) ION, Pirin | Authors: | Pang, H, Bartlam, M, Zeng, Q, Gao, G.F, Rao, Z. | Deposit date: | 2002-12-10 | Release date: | 2003-12-16 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor J.Biol.Chem., 279, 2004
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1JSU
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![BU of 1jsu by Molmil](/molmil-images/mine/1jsu) | P27(KIP1)/CYCLIN A/CDK2 COMPLEX | Descriptor: | CYCLIN A, CYCLIN-DEPENDENT KINASE-2, P27, ... | Authors: | Russo, A.A, Jeffrey, P.D, Pavletich, N.P. | Deposit date: | 1996-07-03 | Release date: | 1997-07-29 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature, 382, 1996
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1JST
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![BU of 1jst by Molmil](/molmil-images/mine/1jst) | PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CYCLIN A, CYCLIN-DEPENDENT KINASE-2, ... | Authors: | Russo, A.A, Jeffrey, P.D, Pavletich, N.P. | Deposit date: | 1996-07-03 | Release date: | 1997-01-11 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of cyclin-dependent kinase activation by phosphorylation. Nat.Struct.Biol., 3, 1996
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2LQ8
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![BU of 2lq8 by Molmil](/molmil-images/mine/2lq8) | Domain interaction in Thermotoga maritima NusG | Descriptor: | Transcription antitermination protein nusG | Authors: | Droegemueller, J, Stegmann, C, Burmann, B, Roesch, P, Wahl, M.C, Schweimer, K. | Deposit date: | 2012-02-27 | Release date: | 2013-01-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | An Autoinhibited State in the Structure of Thermotoga maritima NusG. Structure, 21, 2013
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1HOM
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![BU of 1hom by Molmil](/molmil-images/mine/1hom) | DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY | Descriptor: | ANTENNAPEDIA PROTEIN | Authors: | Qian, Y.-Q, Billeter, M, Otting, G, Muller, M, Gehring, W.J, Wuthrich, K. | Deposit date: | 1991-10-08 | Release date: | 1993-10-31 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Determination of the three-dimensional structure of the Antennapedia homeodomain from Drosophila in solution by 1H nuclear magnetic resonance spectroscopy. J.Mol.Biol., 214, 1990
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1E6C
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![BU of 1e6c by Molmil](/molmil-images/mine/1e6c) | K15M MUTANT OF SHIKIMATE KINASE FROM ERWINIA CHRYSANTHEMI | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ... | Authors: | Maclean, J, Krell, T, Coggins, J.R, Lapthorn, A.J. | Deposit date: | 2000-08-10 | Release date: | 2001-06-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Biochemical and X-Ray Crystallographic Studies on Shikimate Kinase: The Important Structural Role of the P-Loop Lysine Protein Sci., 10, 2001
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1KBH
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![BU of 1kbh by Molmil](/molmil-images/mine/1kbh) | Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR | Descriptor: | CREB-BINDING PROTEIN, nuclear receptor coactivator | Authors: | Demarest, S.J, Martinez-Yamout, M, Chung, J, Chen, H, Xu, W, Dyson, H.J, Evans, R.M, Wright, P.E. | Deposit date: | 2001-11-06 | Release date: | 2002-02-06 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature, 415, 2002
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1K8K
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![BU of 1k8k by Molmil](/molmil-images/mine/1k8k) | Crystal Structure of Arp2/3 Complex | Descriptor: | ACTIN-LIKE PROTEIN 2, ACTIN-LIKE PROTEIN 3, ARP2/3 COMPLEX 16 KDA SUBUNIT, ... | Authors: | Robinson, R.C, Turbedsky, K, Kaiser, D.A, Higgs, H.N, Marchand, J.-B, Choe, S, Pollard, T.D. | Deposit date: | 2001-10-24 | Release date: | 2001-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of Arp2/3 Complex Science, 294, 2001
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1JTC
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![BU of 1jtc by Molmil](/molmil-images/mine/1jtc) | Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE (L44F) | Descriptor: | FORMIC ACID, acidic fibroblast growth factor | Authors: | Brych, S.R, Blaber, S.I, Logan, T.M, Blaber, M. | Deposit date: | 2001-08-20 | Release date: | 2001-12-19 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core
region of a beta-trefoil. Protein Sci., 10, 2001
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7C9I
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![BU of 7c9i by Molmil](/molmil-images/mine/7c9i) | Human gamma-secretase in complex with small molecule L-685,458 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, G, Zhou, R, Guo, X, Lei, J, Yan, C, Shi, Y. | Deposit date: | 2020-06-05 | Release date: | 2021-01-27 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184, 2021
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1JOW
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1K99
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1JK9
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![BU of 1jk9 by Molmil](/molmil-images/mine/1jk9) | Heterodimer between H48F-ySOD1 and yCCS | Descriptor: | SULFATE ION, ZINC ION, copper chaperone for superoxide dismutase, ... | Authors: | Lamb, A.L, Torres, A.S, O'Halloran, T.V, Rosenzweig, A.C. | Deposit date: | 2001-07-11 | Release date: | 2001-09-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Heterodimeric structure of superoxide dismutase in complex with its metallochaperone. Nat.Struct.Biol., 8, 2001
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1JQZ
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![BU of 1jqz by Molmil](/molmil-images/mine/1jqz) | Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag. | Descriptor: | FORMIC ACID, acidic fibroblast growth factor | Authors: | Brych, S.R, Blaber, S.I, Logan, T.M, Blaber, M. | Deposit date: | 2001-08-09 | Release date: | 2001-12-19 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core
region of a beta-trefoil. Protein Sci., 10, 2001
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1GII
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![BU of 1gii by Molmil](/molmil-images/mine/1gii) | HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR | Descriptor: | 1-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1-A]ISOINDOL-9-YL)-3-PYRIDIN-2-YL-UREA, CELL DIVISION PROTEIN KINASE 2 | Authors: | Ikuta, M, Nishimura, S. | Deposit date: | 2001-02-06 | Release date: | 2002-02-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein. J.Biol.Chem., 276, 2001
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