5MFX
| Zika NS3 helicase:RNA complex | Descriptor: | ACETATE ION, CITRATE ANION, Genome polyprotein, ... | Authors: | Jenkins, H.T, Ge, M, Chechik, M, Greive, S.J, Antson, A.A. | Deposit date: | 2016-11-18 | Release date: | 2017-01-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.598 Å) | Cite: | How Zika virus NS3 helicase grips the first
nucleotide of the leading RNA strand To Be Published
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3GDH
| Methyltransferase domain of human Trimethylguanosine Synthase 1 (TGS1) bound to m7GTP and adenosyl-homocysteine (active form) | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, R-1,2-PROPANEDIOL, S-1,2-PROPANEDIOL, ... | Authors: | Monecke, T, Dickmanns, A, Ficner, R. | Deposit date: | 2009-02-24 | Release date: | 2009-06-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1. Nucleic Acids Res., 37, 2009
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1O9H
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3ZNN
| IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN | Descriptor: | 4H-THIENO[3,2-B]PYROLE-5-CARBOXYLIC ACID, D-AMINO-ACID OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Hopkins, S.C, Heffernan, M.L.R, Saraswat, L.D, Bowen, C.A, Melnick, L, Hardy, L.W, Orsini, M.A, Allen, M.S, Koch, P, Spear, K.L, Foglesong, R.J, Soukri, M, Chytil, M, Fang, Q.K, Jones, S.W, Varney, M.A, Panatier, A, Oliet, S.H.R, Pollegioni, L, Piubelli, L, Molla, G, Nardini, M, Large, T.H. | Deposit date: | 2013-02-15 | Release date: | 2013-05-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural, Kinetic, and Pharmacodynamic Mechanisms of D-Amino Acid Oxidase Inhibition by Small Molecules. J.Med.Chem., 56, 2013
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3ZNP
| IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN | Descriptor: | 3-HYDROXY-2H-CHROMEN-2-ONE, D-AMINO-ACID OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Hopkins, S.C, Heffernan, M.L.R, Saraswat, L.D, Bowen, C.A, Melnick, L, Hardy, L.W, Orsini, M.A, Allen, M.S, Koch, P, Spear, K.L, Foglesong, R.J, Soukri, M, Chytil, M, Fang, Q.K, Jones, S.W, Varney, M.A, Panatier, A, Oliet, S.H.R, Pollegioni, L, Piubelli, L, Molla, G, Nardini, M, Large, T.H. | Deposit date: | 2013-02-15 | Release date: | 2013-05-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural, Kinetic, and Pharmacodynamic Mechanisms of D-Amino Acid Oxidase Inhibition by Small Molecules. J.Med.Chem., 56, 2013
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3ZNO
| IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN | Descriptor: | 4-(4-chlorophenethyl)-1H-pyrrole-2-carboxylic acid, D-AMINO-ACID OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Hopkins, S.C, Heffernan, M.L.R, Saraswat, L.D, Bowen, C.A, Melnick, L, Hardy, L.W, Orsini, M.A, Allen, M.S, Koch, P, Spear, K.L, Foglesong, R.J, Soukri, M, Chytil, M, Fang, Q.K, Jones, S.W, Varney, M.A, Panatier, A, Oliet, S.H.R, Pollegioni, L, Piubelli, L, Molla, G, Nardini, M, Large, T.H. | Deposit date: | 2013-02-15 | Release date: | 2013-05-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural, Kinetic, and Pharmacodynamic Mechanisms of D-Amino Acid Oxidase Inhibition by Small Molecules. J.Med.Chem., 56, 2013
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3ZNQ
| IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN | Descriptor: | 3-PHENETHYL-4H-FURO[3,2-B]PYRROLE-5-CARBOXYLIC ACID, D-AMINO-ACID OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Hopkins, S.C, Heffernan, M.L.R, Saraswat, L.D, Bowen, C.A, Melnick, L, Hardy, L.W, Orsini, M.A, Allen, M.S, Koch, P, Spear, K.L, Foglesong, R.J, Soukri, M, Chytil, M, Fang, Q.K, Jones, S.W, Varney, M.A, Panatier, A, Oliet, S.H.R, Pollegioni, L, Piubelli, L, Molla, G, Nardini, M, Large, T.H. | Deposit date: | 2013-02-15 | Release date: | 2013-05-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural, Kinetic, and Pharmacodynamic Mechanisms of D-Amino Acid Oxidase Inhibition by Small Molecules. J.Med.Chem., 56, 2013
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1Y95
| HIV-1 Dis(Mal) Duplex Pb-Soaked | Descriptor: | 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3', LEAD (II) ION, MAGNESIUM ION | Authors: | Ennifar, E, Walter, P, Dumas, P. | Deposit date: | 2004-12-14 | Release date: | 2004-12-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A crystallographic study of the binding of 13 metal ions to two related RNA duplexes Nucleic Acids Res., 31, 2003
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4DHX
| ENY2:GANP complex | Descriptor: | 80 kDa MCM3-associated protein, Enhancer of yellow 2 transcription factor homolog | Authors: | Stewart, M, Jani, D. | Deposit date: | 2012-01-30 | Release date: | 2012-06-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export. Nucleic Acids Res., 40, 2012
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1O9G
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1MDG
| An Alternating Antiparallel Octaplex in an RNA Crystal Structure | Descriptor: | 5'-R(*UP*(BGM)GP*AP*GP*GP*U)-3', COBALT HEXAMMINE(III), SODIUM ION | Authors: | Pan, B.C, Xiong, Y, Shi, K, Sundaralingam, M. | Deposit date: | 2002-08-07 | Release date: | 2003-08-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | An Eight-Stranded Helical Fragment in RNA Crystal Structure: Implications for Tetraplex Interaction Structure, 11, 2003
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1Y73
| HIV-1 Dis(Mal) Duplex Pt-Soaked | Descriptor: | 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3', MAGNESIUM ION, PLATINUM (IV) ION | Authors: | Ennifar, E, Walter, P, Dumas, P. | Deposit date: | 2004-12-08 | Release date: | 2004-12-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A crystallographic study of the binding of 13 metal ions to two related RNA duplexes Nucleic Acids Res., 31, 2003
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1A1V
| HEPATITIS C VIRUS NS3 HELICASE DOMAIN COMPLEXED WITH SINGLE STRANDED SDNA | Descriptor: | DNA (5'-D(*UP*UP*UP*UP*UP*UP*UP*U)-3'), PROTEIN (NS3 PROTEIN), SULFATE ION | Authors: | Kim, J.L, Morgenstern, K.A, Griffith, J.P, Dwyer, M.D, Thomson, J.A, Murcko, M.A, Lin, C, Caron, P.R. | Deposit date: | 1997-12-17 | Release date: | 1999-01-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding. Structure, 6, 1998
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1Y6S
| HIV-1 DIS(Mal) duplex Ba-soaked | Descriptor: | 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3', BARIUM ION | Authors: | Ennifar, E, Walter, P, Dumas, P. | Deposit date: | 2004-12-07 | Release date: | 2004-12-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A crystallographic study of the binding of 13 metal ions to two related RNA duplexes Nucleic Acids Res., 31, 2003
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5ZH4
| CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-7 | Descriptor: | (3R)-6,8-dihydroxy-3-{[(2S,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, CHLORIDE ION, LYSINE, ... | Authors: | Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. | Deposit date: | 2018-03-11 | Release date: | 2018-06-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite J. Med. Chem., 61, 2018
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1Y6T
| HIV-1 Dis(Mal) Duplex Co Hexamine-Soaked | Descriptor: | 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3', COBALT (III) ION, SODIUM ION | Authors: | Ennifar, E, Walter, P, Dumas, P. | Deposit date: | 2004-12-07 | Release date: | 2004-12-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A crystallographic study of the binding of 13 metal ions to two related RNA duplexes Nucleic Acids Res., 31, 2003
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3LVJ
| Crystal Structure of E.coli IscS-TusA complex (form 1) | Descriptor: | Cysteine desulfurase, PYRIDOXAL-5'-PHOSPHATE, Sulfurtransferase tusA | Authors: | Shi, R, Proteau, A, Matte, A, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | Deposit date: | 2010-02-22 | Release date: | 2010-04-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.435 Å) | Cite: | Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions. Plos Biol., 8, 2010
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3AGV
| Crystal structure of a human IgG-aptamer complex | Descriptor: | 5'-R(*GP*GP*AP*GP*GP*(UFT)P*GP*(CFZ)P*(UFT)P*(CFZ)P*(CFZ)P*GP*AP*AP*A*GP*GP*AP*AP*(CFZ)P*(UFT)P*(CFZ)P*(CFZ)P*A)-3', CALCIUM ION, Ig gamma-1 chain C region, ... | Authors: | Nomura, Y, Sugiyama, S, Sakamoto, T, Miyakawa, S, Adachi, H, Takano, K, Murakami, S, Inoue, T, Mori, Y, Nakamura, Y, Matsumura, H. | Deposit date: | 2010-04-08 | Release date: | 2010-11-10 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Conformational plasticity of RNA for target recognition as revealed by the 2.15 A crystal structure of a human IgG-aptamer complex Nucleic Acids Res., 38, 2010
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5ZH3
| CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-6 | Descriptor: | (3S)-6,8-dihydroxy-3-{[(2R,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, LYSINE, Lysine-tRNA ligase | Authors: | Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. | Deposit date: | 2018-03-11 | Release date: | 2018-06-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.86 Å) | Cite: | Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite J. Med. Chem., 61, 2018
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3LVK
| Crystal Structure of E.coli IscS-TusA complex (form 2) | Descriptor: | Cysteine desulfurase, PYRIDOXAL-5'-PHOSPHATE, Sulfurtransferase tusA | Authors: | Shi, R, Proteau, A, Matte, A, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | Deposit date: | 2010-02-22 | Release date: | 2010-04-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.442 Å) | Cite: | Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions. Plos Biol., 8, 2010
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1PGL
| BEAN POD MOTTLE VIRUS (BPMV), MIDDLE COMPONENT | Descriptor: | 5'-R(*AP*GP*UP*CP*UP*C)-3', BEAN POD MOTTLE VIRUS LARGE (L) SUBUNIT, BEAN POD MOTTLE VIRUS SMALL (S) SUBUNIT | Authors: | Lin, T, Cavarelli, J, Johnson, J.E. | Deposit date: | 2003-05-28 | Release date: | 2003-11-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Evidence for assembly-dependent folding of protein and RNA in an icosahedral virus. Virology, 314, 2003
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5ZH5
| CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-2 | Descriptor: | (3S)-6,8-dihydroxy-3-{[(2R,6S)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, CHLORIDE ION, LYSINE, ... | Authors: | Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. | Deposit date: | 2018-03-11 | Release date: | 2018-06-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.08 Å) | Cite: | Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite J. Med. Chem., 61, 2018
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4OKE
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4OKJ
| Crystal structure of RNase AS from M tuberculosis | Descriptor: | 3'-5' exoribonuclease Rv2179c/MT2234.1, MAGNESIUM ION | Authors: | Romano, M, van de Weerd, R, Brouwer, F.C.C, Roviello, G.N, Lacroix, R, Sparrius, M, van den Brink-van Stempvoort, G, Maaskant, J.J, van der Sar, A.M, Appelmelk, B.J, Geurtsen, J.J, Berisio, R. | Deposit date: | 2014-01-22 | Release date: | 2014-05-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and Function of RNase AS, a Polyadenylate-Specific Exoribonuclease Affecting Mycobacterial Virulence In Vivo Structure, 22, 2014
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4OKK
| Crystal structure of RNase AS from M tuberculosis in complex with UMP | Descriptor: | 3'-5' exoribonuclease Rv2179c/MT2234.1, MAGNESIUM ION, URIDINE-5'-MONOPHOSPHATE | Authors: | Romano, M, van de Weerd, R, Brouwer, F.C.C, Roviello, G.N, Lacroix, R, Sparrius, M, van den Brink-van Stempvoort, G, Maaskant, J.J, van der Sar, A.M, Appelmelk, B.J, Geurtsen, J.J, Berisio, R. | Deposit date: | 2014-01-22 | Release date: | 2014-05-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structure and Function of RNase AS, a Polyadenylate-Specific Exoribonuclease Affecting Mycobacterial Virulence In Vivo Structure, 22, 2014
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