3GDH

Methyltransferase domain of human Trimethylguanosine Synthase 1 (TGS1) bound to m7GTP and adenosyl-homocysteine (active form)

Summary for 3GDH

Entry DOI	10.2210/pdb3gdh/pdb
Descriptor	Trimethylguanosine synthase homolog, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, ... (6 entities in total)
Functional Keywords	m7g, cap, dimethyltransferase, usnrna, snorna, telomerase, cytoplasm, methyltransferase, nucleus, phosphoprotein, polymorphism, transcription, transcription regulation, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q96RS0
Total number of polymer chains	3
Total formula weight	83379.70
Authors	Monecke, T.,Dickmanns, A.,Ficner, R. (deposition date: 2009-02-24, release date: 2009-06-23, Last modification date: 2024-02-21)
Primary citation	Monecke, T.,Dickmanns, A.,Ficner, R. Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1. Nucleic Acids Res., 37:3865-3877, 2009 Cited by PubMed: 19386620 DOI: 10.1093/nar/gkp249 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation