3GDH

Methyltransferase domain of human Trimethylguanosine Synthase 1 (TGS1) bound to m7GTP and adenosyl-homocysteine (active form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001510	biological_process	RNA methylation
A	0008168	molecular_function	methyltransferase activity
A	0036261	biological_process	7-methylguanosine cap hypermethylation
B	0001510	biological_process	RNA methylation
B	0008168	molecular_function	methyltransferase activity
B	0036261	biological_process	7-methylguanosine cap hypermethylation
C	0001510	biological_process	RNA methylation
C	0008168	molecular_function	methyltransferase activity
C	0036261	biological_process	7-methylguanosine cap hypermethylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE MGP A 1

Chain	Residue
A	HOH2
A	SER671
A	VAL672
A	PRO674
A	SER763
A	PRO764
A	TRP766
A	GLY768
A	TYR771
A	ARG807
A	LYS836
A	HOH10
A	THR837
A	PGR855
A	HOH856
A	HOH857
A	HOH214
A	HOH223
A	HOH262
A	HOH312
A	LYS646
A	TYR647
A	PHE670

---

site_id	AC2
Number of Residues	25
Details	BINDING SITE FOR RESIDUE SAH A 854

Chain	Residue
A	HOH5
A	HOH26
A	HOH169
A	HOH170
A	HOH241
A	GLU667
A	SER671
A	VAL672
A	THR673
A	ALA697
A	PHE698
A	CYS699
A	GLY700
A	VAL701
A	GLY702
A	GLY703
A	ASN704
A	ASP719
A	ILE720
A	LYS724
A	GLY746
A	ASP747
A	PHE748
A	SER763
A	PRO765

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGR A 855

Chain	Residue
A	MGP1
A	TYR647
A	GLN650
A	LYS836

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGR A 4

Chain	Residue
A	GLU733
A	GLY736
A	ILE737
A	ALA738
A	ASP739

---

site_id	AC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE MGP B 2

Chain	Residue
B	HOH67
B	HOH96
B	LYS646
B	TYR647
B	PHE670
B	SER671
B	VAL672
B	PRO674
B	SER763
B	PRO764
B	TRP766
B	GLY768
B	TYR771
B	ARG807
B	LYS836
B	THR837
B	PGR855

---

site_id	AC6
Number of Residues	22
Details	BINDING SITE FOR RESIDUE SAH B 854

Chain	Residue
B	HOH65
B	HOH66
B	HOH99
B	HOH284
B	GLU667
B	SER671
B	THR673
B	ALA697
B	PHE698
B	CYS699
B	GLY700
B	VAL701
B	GLY702
B	GLY703
B	ASN704
B	ASP719
B	ILE720
B	LYS724
B	ASP747
B	PHE748
B	SER763
B	PRO765

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGR B 855

Chain	Residue
B	GLN650
B	LYS836
B	MGP2
B	LYS646
B	TYR647

---

site_id	AC8
Number of Residues	19
Details	BINDING SITE FOR RESIDUE MGP C 3

Chain	Residue
C	HOH115
C	HOH209
C	LYS646
C	TYR647
C	PHE670
C	SER671
C	VAL672
C	THR673
C	PRO674
C	SER763
C	PRO764
C	TRP766
C	GLY768
C	TYR771
C	ARG807
C	LYS834
C	LYS836
C	THR837
C	PGR855

---

site_id	AC9
Number of Residues	23
Details	BINDING SITE FOR RESIDUE SAH C 854

Chain	Residue
C	HOH117
C	HOH124
C	GLU667
C	SER671
C	VAL672
C	THR673
C	ALA697
C	PHE698
C	CYS699
C	GLY700
C	VAL701
C	GLY702
C	GLY703
C	ASN704
C	ASP719
C	ILE720
C	LYS724
C	GLY746
C	ASP747
C	PHE748
C	LEU749
C	SER763
C	PRO765

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGR C 855

Chain	Residue
C	MGP3
C	TYR647
C	GLN650
C	LYS836

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PGO C 856

Chain	Residue
C	HOH254
C	ALA732
C	GLU733
C	GLY736
C	ILE737
C	ALA738
C	ASP739

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19386620","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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