8F5Y
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![BU of 8f5y by Molmil](/molmil-images/mine/8f5y) | Crystal structure of pregnane X receptor ligand binding domain complexed with JQ1 | Descriptor: | (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, Nuclear receptor coactivator 1, Nuclear receptor subfamily 1 group I member 2 | Authors: | Huber, A.D, Poudel, S, Seetharaman, J, Miller, D.J, Chen, T. | Deposit date: | 2022-11-15 | Release date: | 2024-02-21 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR. Nucleic Acids Res., 52, 2024
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7FU5
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![BU of 7fu5 by Molmil](/molmil-images/mine/7fu5) | Crystal Structure of human cyclic GMP-AMP synthase | Descriptor: | (8S)-2-{[(3-fluoro[1,1'-biphenyl]-4-yl)methyl]amino}-5-propyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one, Cyclic GMP-AMP synthase, SULFATE ION, ... | Authors: | Leibrock, L, Benz, J, Groebke-Zbinden, K, Rudolph, M.G. | Deposit date: | 2023-02-08 | Release date: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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8OHI
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![BU of 8ohi by Molmil](/molmil-images/mine/8ohi) | Structure of the Fmoc-Tau-PAM4 Type 2 amyloid fibril | Descriptor: | Microtubule-associated protein tau | Authors: | Wilkinson, M, Louros, N, Tsaka, G, Ramakers, M, Morelli, C, Garcia, T, Gallardo, R.U, D'Haeyer, S, Goossens, V, Audenaert, D, Thal, D.R, Ranson, N.A, Radford, S.E, Rousseau, F, Schymkowitz, J. | Deposit date: | 2023-03-21 | Release date: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Local structural preferences in shaping tau amyloid polymorphism. Nat Commun, 15, 2024
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8OH2
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![BU of 8oh2 by Molmil](/molmil-images/mine/8oh2) | Structure of the Tau-PAM4 Type 1 amyloid fibril | Descriptor: | Microtubule-associated protein tau | Authors: | Wilkinson, M, Louros, N, Tsaka, G, Ramakers, M, Morelli, C, Garcia, T, Gallardo, R.U, D'Haeyer, S, Goossens, V, Audenaert, D, Thal, D.R, Ranson, N.A, Radford, S.E, Rousseau, F, Schymkowitz, J. | Deposit date: | 2023-03-20 | Release date: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Local structural preferences in shaping tau amyloid polymorphism. Nat Commun, 15, 2024
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8OHP
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![BU of 8ohp by Molmil](/molmil-images/mine/8ohp) | Structure of the Fmoc-Tau-PAM4 Type 3 amyloid fibril | Descriptor: | Microtubule-associated protein tau | Authors: | Wilkinson, M, Louros, N, Tsaka, G, Ramakers, M, Morelli, C, Garcia, T, Gallardo, R.U, D'Haeyer, S, Goossens, V, Audenaert, D, Thal, D.R, Ranson, N.A, Radford, S.E, Rousseau, F, Schymkowitz, J. | Deposit date: | 2023-03-21 | Release date: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Local structural preferences in shaping tau amyloid polymorphism. Nat Commun, 15, 2024
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8OI0
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![BU of 8oi0 by Molmil](/molmil-images/mine/8oi0) | Structure of the Fmoc-Tau-PAM4 Type 4 amyloid fibril | Descriptor: | Microtubule-associated protein tau | Authors: | Wilkinson, M, Louros, N, Tsaka, G, Ramakers, M, Morelli, C, Garcia, T, Gallardo, R.U, D'Haeyer, S, Goossens, V, Audenaert, D, Thal, D.R, Ranson, N.A, Radford, S.E, Rousseau, F, Schymkowitz, J. | Deposit date: | 2023-03-21 | Release date: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Local structural preferences in shaping tau amyloid polymorphism. Nat Commun, 15, 2024
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8OPB
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![BU of 8opb by Molmil](/molmil-images/mine/8opb) | |
8OT1
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![BU of 8ot1 by Molmil](/molmil-images/mine/8ot1) | |
8OT3
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![BU of 8ot3 by Molmil](/molmil-images/mine/8ot3) | |
8OT4
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![BU of 8ot4 by Molmil](/molmil-images/mine/8ot4) | |
8X36
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![BU of 8x36 by Molmil](/molmil-images/mine/8x36) | Neryl diphosphate synthase from Solanum lycopersicum complexed with DMSAPP, IPP, and magnesium ion (form B) | Descriptor: | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, DIMETHYLALLYL S-THIOLODIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Imaizumi, R, Matsuura, H, Yanai, T, Takeshita, K, Misawa, S, Yamaguchi, H, Sakai, N, Miyagi-Inoue, Y, Suenaga-Hiromori, M, Kataoka, K, Nakayama, T, Yamamoto, M, Takahashi, S, Yamashita, S. | Deposit date: | 2023-11-12 | Release date: | 2024-02-07 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural-Functional Correlations between Unique N-terminal Region and C-terminal Conserved Motif in Short-chain cis-Prenyltransferase from Tomato. Chembiochem, 25, 2024
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8X35
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![BU of 8x35 by Molmil](/molmil-images/mine/8x35) | Neryl diphosphate synthase from Solanum lycopersicum complexed with DMSAPP, IPP, and magnesium ion (form A) | Descriptor: | 1,2-ETHANEDIOL, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Imaizumi, R, Matsuura, H, Yanai, T, Takeshita, K, Misawa, S, Yamaguchi, H, Sakai, N, Miyagi-Inoue, Y, Suenaga-Hiromori, M, Kataoka, K, Nakayama, T, Yamamoto, M, Takahashi, S, Yamashita, S. | Deposit date: | 2023-11-12 | Release date: | 2024-02-07 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural-Functional Correlations between Unique N-terminal Region and C-terminal Conserved Motif in Short-chain cis-Prenyltransferase from Tomato. Chembiochem, 25, 2024
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8X37
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![BU of 8x37 by Molmil](/molmil-images/mine/8x37) | Neryl diphosphate synthase from Solanum lycopersicum complexed with DMSAPP | Descriptor: | DIMETHYLALLYL S-THIOLODIPHOSPHATE, MAGNESIUM ION, Neryl-diphosphate synthase 1 | Authors: | Imaizumi, R, Matsuura, H, Yanai, T, Takeshita, K, Misawa, S, Yamaguchi, H, Sakai, N, Miyagi-Inoue, Y, Suenaga-Hiromori, M, Kataoka, K, Nakayama, T, Yamamoto, M, Takahashi, S, Yamashita, S. | Deposit date: | 2023-11-12 | Release date: | 2024-02-07 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Structural-Functional Correlations between Unique N-terminal Region and C-terminal Conserved Motif in Short-chain cis-Prenyltransferase from Tomato. Chembiochem, 25, 2024
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8AFX
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![BU of 8afx by Molmil](/molmil-images/mine/8afx) | Single particle structure of Atg18-WT | Descriptor: | Autophagy-related protein 18 | Authors: | Mann, D, Fromm, S, Martinez-Sanchez, A, Gopaldass, N, Mayer, A, Sachse, C. | Deposit date: | 2022-07-18 | Release date: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Cryo-EM structures of Atg18 oligomers reveal a tilted structural scaffold for Atg2 at the isolation membrane To Be Published
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8CGP
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![BU of 8cgp by Molmil](/molmil-images/mine/8cgp) | Insulin regulated aminopeptidase (IRAP) in complex with an allosteric aryl sulfonamide inhibitor | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Mpakali, A, Stratikos, E, Giastas, P. | Deposit date: | 2023-02-06 | Release date: | 2024-01-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase. J.Mol.Biol., 436, 2024
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8CNZ
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![BU of 8cnz by Molmil](/molmil-images/mine/8cnz) | mmLarE-[4Fe-4S] phased by Fe-SAD | Descriptor: | CHLORIDE ION, IODIDE ION, IRON/SULFUR CLUSTER, ... | Authors: | Pecqueur, L, Zecchin, P, Golinelli-Pimpaneau, B. | Deposit date: | 2023-02-24 | Release date: | 2024-01-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structure-based insights into the mechanism of [4Fe-4S]-dependent sulfur insertase LarE. Protein Sci., 33, 2024
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8CGW
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![BU of 8cgw by Molmil](/molmil-images/mine/8cgw) | Insulin-regulated aminopeptidase (IRAP) in complex with an allosteric benzopyran-based inhibitor | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Mpakali, A, Stratikos, E, Giastas, P. | Deposit date: | 2023-02-06 | Release date: | 2024-01-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase. J.Mol.Biol., 436, 2024
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8U1V
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8OGI
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![BU of 8ogi by Molmil](/molmil-images/mine/8ogi) | Structure of native human eosinophil peroxidase | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Pfanzagl, V, Obinger, C. | Deposit date: | 2023-03-20 | Release date: | 2024-01-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.547 Å) | Cite: | Posttranslational modification and heme cavity architecture of human eosinophil peroxidase-insights from first crystal structure and biochemical characterization. J.Biol.Chem., 299, 2023
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8OPC
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8OPG
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8OPJ
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8OTL
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![BU of 8otl by Molmil](/molmil-images/mine/8otl) | structure of InhA from Mycobacterium tuberculosis in complex with 5-(((4-(2-hydroxyphenoxy)benzyl)(octyl)amino)methyl)-2-phenoxyphenol | Descriptor: | 1,2-ETHANEDIOL, 5-[[octyl-[[4-(2-oxidanylphenoxy)phenyl]methyl]amino]methyl]-2-phenoxy-phenol, ACETATE ION, ... | Authors: | Tamhaev, R, Maveyraud, L, Chebaiki, M, Lherbet, C, Mourey, L. | Deposit date: | 2023-04-21 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.108 Å) | Cite: | Exploring the plasticity of the InhA substrate-binding site using new diaryl ether inhibitors. Bioorg.Chem., 143, 2023
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8OPD
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8OPL
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![BU of 8opl by Molmil](/molmil-images/mine/8opl) | |