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8TUT	Merkel Cell Polyomavirus LTA NLSct bound to importin alpha 2 Descriptor: Importin subunit alpha-1, PRO-PRO-LYS-PRO-LYS-LYS-ASN-ARG-GLU Authors: Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.55 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8TUQ	STL Polyomavirus LTA NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Large T antigen Authors: Donnelly, C.M, Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8TUR	Merkel Cell Polyomavirus LTA bipartite NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Truncated large T antigen Authors: Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.15 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8TUS	WU Polyomavirus LTA NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Large T antigen Authors: Donnelly, C.M, Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
5XZX	Crystal structure of importin-alpha3 bound to the nuclear localization signal of Ran-binding protein 3 Descriptor: Importin subunit alpha-3, Ran-binding protein 3 Authors: Koyama, M, Matsuura, Y. Deposit date: 2017-07-14 Release date: 2017-08-09 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structure of importin-alpha 3 bound to the nuclear localization signal of Ran-binding protein 3 Biochem. Biophys. Res. Commun., 491, 2017
4B18	The crystal structure of human Importin alpha 5 with TERT NLS peptide Descriptor: IMPORTIN SUBUNIT ALPHA-1, TELOMERASE REVERSE TRANSCRIPTASE Authors: Kim, K.L, Yoo, J.H, Cho, H.S. Deposit date: 2012-07-08 Release date: 2013-09-04 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Akt-Mediated Phosphorylation Increases the Binding Affinity of Htert for Importin Alpha to Promote Nuclear Translocation. J.Cell.Sci., 128, 2015
5B56	Crystal structure of HIV-1 VPR C-Terminal domain and DIBB-M-Importin-Alpha2 complex Descriptor: Importin subunit alpha-1, Protein Vpr Authors: Miyatake, H, Sanjoh, A, Matusda, G, Murakami, T, Murakami, H, Hagiwara, K, Yokoyama, M, Sato, H, Miyamoto, Y, Dohmae, N, Aida, Y. Deposit date: 2016-04-25 Release date: 2016-06-01 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Molecular Mechanism of HIV-1 Vpr for Binding to Importin-alpha J.Mol.Biol., 428, 2016
8FK3	Adeno-Associated Virus Porcine Origin capsid protein basic regions in complex with Importin-alpha 2 Descriptor: Importin subunit alpha-1, VP1 Authors: Hoad, M, Forwood, J.K, Roby, J.A. Deposit date: 2022-12-20 Release date: 2023-03-01 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal. Viruses, 15, 2023
6BWB	Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 3 Descriptor: Importin subunit alpha-3, Protein W Authors: Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. Deposit date: 2017-12-14 Release date: 2018-07-04 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
6BWA	Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 2 Descriptor: Importin subunit alpha-3, Protein W Authors: Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. Deposit date: 2017-12-14 Release date: 2018-07-04 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
6BW9	Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 1 Descriptor: Importin subunit alpha-3, Protein W Authors: Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. Deposit date: 2017-12-14 Release date: 2018-07-04 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
5V5P	Structure of NLS2R of influenza A virus nucleoprotein bound to importin alpha Descriptor: Importin subunit alpha-1, Nucleoprotein Authors: Sankhala, R.S, Lokareddy, R.K, Cingolani, G. Deposit date: 2017-03-14 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin alpha isoforms. Sci Rep, 7, 2017
5V5O	Structure of NLS2K of influenza A virus nucleoprotein bound to importin alpha Descriptor: Importin subunit alpha-1, Nucleoprotein Authors: Sankhala, R.S, Lokareddy, R.K, Cingolani, G. Deposit date: 2017-03-14 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.243 Å) Cite: Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin alpha isoforms. Sci Rep, 7, 2017
3UL1	Mouse importin alpha: nucleoplasmin cNLS peptide complex Descriptor: Importin subunit alpha-2, Nucleoplasmin Authors: Marfori, M, Forwood, J.K, Lonhienne, T.G, Kobe, B. Deposit date: 2011-11-10 Release date: 2012-10-03 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Basis of High-Affinity Nuclear Localization Signal Interactions with Importin-alpha Traffic, 13, 2012
3UL0	Mouse importin alpha: mouse CBP80Y8D cNLS complex Descriptor: Importin subunit alpha-2, Nuclear cap-binding protein subunit 1 Authors: Marfori, M, Forwood, J.K, Lonhienne, T.G, Kobe, B. Deposit date: 2011-11-10 Release date: 2012-10-03 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis of High-Affinity Nuclear Localization Signal Interactions with Importin-alpha Traffic, 13, 2012
3UKY	Mouse importin alpha: yeast CBP80 cNLS complex Descriptor: Importin subunit alpha-2, Nuclear cap-binding protein complex subunit 1 Authors: Marfori, M, Forwood, J.K, Lonhienne, T.G, Kobe, B. Deposit date: 2011-11-10 Release date: 2012-10-03 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structural Basis of High-Affinity Nuclear Localization Signal Interactions with Importin-alpha Traffic, 13, 2012
3UKZ	Mouse importin alpha: mouse CBP80 cNLS complex Descriptor: Importin subunit alpha-2, Nuclear cap-binding protein subunit 1 Authors: Marfori, M, Forwood, J.K, Lonhienne, T.G, Kobe, B. Deposit date: 2011-11-10 Release date: 2012-10-03 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Basis of High-Affinity Nuclear Localization Signal Interactions with Importin-alpha Traffic, 13, 2012
6BW0	Nipah virus W protein C-terminus in complex with Importin alpha 1 Descriptor: Importin subunit alpha-1, Protein W Authors: Smith, K.M, Tsimbalyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. Deposit date: 2017-12-14 Release date: 2018-07-04 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
3TJ3	Structure of importin a5 bound to the N-terminus of Nup50 Descriptor: Importin subunit alpha-1, Nuclear pore complex protein Nup50 Authors: Pumroy, R, Nardozzi, J.D, Hart, D.J, Root, M.J, Cingolani, G. Deposit date: 2011-08-23 Release date: 2011-11-30 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.702 Å) Cite: Nucleoporin Nup50 stabilizes closed conformation of armadillo repeat 10 in importin alpha 5. J.Biol.Chem., 287, 2012
5W41	Zika MR766 NLS in complex with Importin alpha subunit-1 Descriptor: Importin subunit alpha-1, ZIKA MR766 NLS Authors: Jeffress, S, Smith, K.M, Forwood, J.K. Deposit date: 2017-06-08 Release date: 2018-06-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Zika virus NS5 forms supramolecular nuclear bodies that sequester importin alpha and modulate the host immune and pro-inflammatory response in neuronal cells. ACS Infect Dis, 2019
5VQI	Nuclear transport of the Neurospora crassa NIT2 transcription factor is mediated by Importin-alpha Descriptor: Importin subunit alpha, Nuclear localization sequence of NIT2 transcription factor (NIT2-NLS) Authors: Bernardes, N.E, Fontes, M.R.M. Deposit date: 2017-05-09 Release date: 2017-11-01 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.501 Å) Cite: Nuclear transport of the Neurospora crassa NIT-2 transcription factor is mediated by importin-alpha. Biochem. J., 474, 2017
7LFC	Structure of importin a3 bound to p50 NLS Descriptor: Importin subunit alpha-3, Nuclear factor NF-kappa-B p105 subunit Authors: Florio, T.J, Lokareddy, R.K, Cingolani, G. Deposit date: 2021-01-16 Release date: 2022-01-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
7LF4	Structure of importin a3 bound to the p50- and p65-NLSs Descriptor: Importin subunit alpha-3, Nuclear factor NF-kappa-B p105 subunit, Transcription factor p65 Authors: Florio, T.J, Lokareddy, R.K, Cingolani, G. Deposit date: 2021-01-15 Release date: 2022-01-19 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
7LET	Structure of importin a2 bound to the p50- and p65-NLSs Descriptor: Importin subunit alpha-1, Nuclear factor NF-kappa-B p105 subunit, Transcription factor p65 Authors: Florio, T.J, Lokareddy, R.K, Cingolani, G. Deposit date: 2021-01-15 Release date: 2022-01-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
7LEU	Structure of importin a2 bound to p65-NLS Descriptor: Importin subunit alpha-1, Transcription factor p65 Authors: Florio, T.J, Lokareddy, R.K, Cingolani, G. Deposit date: 2021-01-15 Release date: 2022-01-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.82 Å) Cite: Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022

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