5MUO
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![BU of 5muo by Molmil](/molmil-images/mine/5muo) | X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with propofol | Descriptor: | 2,6-BIS(1-METHYLETHYL)PHENOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Fourati, Z, Ruza, R.R, Delarue, M. | Deposit date: | 2017-01-13 | Release date: | 2018-02-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels. Cell Rep, 23, 2018
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5J0Z
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![BU of 5j0z by Molmil](/molmil-images/mine/5j0z) | Crystal structure of GLIC in complex with DHA | Descriptor: | ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ... | Authors: | Basak, S, Schmandt, N, Chakrapani, S. | Deposit date: | 2016-03-28 | Release date: | 2017-03-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel. Elife, 6, 2017
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6WEJ
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![BU of 6wej by Molmil](/molmil-images/mine/6wej) | Structure of cGMP-unbound WT TAX-4 reconstituted in lipid nanodiscs | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel, ... | Authors: | Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J. | Deposit date: | 2020-04-02 | Release date: | 2020-06-03 | Last modified: | 2020-07-22 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Nat.Struct.Mol.Biol., 27, 2020
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6WEL
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![BU of 6wel by Molmil](/molmil-images/mine/6wel) | Structure of cGMP-unbound F403V/V407A mutant TAX-4 reconstituted in lipid nanodiscs | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel, ... | Authors: | Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J. | Deposit date: | 2020-04-02 | Release date: | 2020-06-03 | Last modified: | 2020-07-22 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Nat.Struct.Mol.Biol., 27, 2020
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6WEK
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![BU of 6wek by Molmil](/molmil-images/mine/6wek) | Structure of cGMP-bound WT TAX-4 reconstituted in lipid nanodiscs | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CYCLIC GUANOSINE MONOPHOSPHATE, ... | Authors: | Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J. | Deposit date: | 2020-04-02 | Release date: | 2020-06-03 | Last modified: | 2020-07-22 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Nat.Struct.Mol.Biol., 27, 2020
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1WQK
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![BU of 1wqk by Molmil](/molmil-images/mine/1wqk) | Solution structure of APETx1, a specific peptide inhibitor of human Ether-a-go-go-related gene potassium channels from the venom of the sea anemone Anthopleura elegantissima: a new fold for an HERG toxin | Descriptor: | Toxin APETx1 | Authors: | Chagot, B, Diochot, S, Pimentel, C, Lazdunski, M, Darbon, H. | Deposit date: | 2004-09-30 | Release date: | 2005-03-08 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Solution structure of APETx1 from the sea anemone Anthopleura elegantissima: A new fold for an HERG toxin Proteins, 59, 2005
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8E59
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![BU of 8e59 by Molmil](/molmil-images/mine/8e59) | Human L-type voltage-gated calcium channel Cav1.3 in the presence of Amiodarone at 3.1 Angstrom resolution | Descriptor: | (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gao, S, Yao, X, Yan, N. | Deposit date: | 2022-08-20 | Release date: | 2022-12-07 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels. Cell, 185, 2022
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8E5B
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![BU of 8e5b by Molmil](/molmil-images/mine/8e5b) | Human L-type voltage-gated calcium channel Cav1.3 in the presence of Amiodarone and Sofosbuvir at 3.3 Angstrom resolution | Descriptor: | (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gao, S, Yao, X, Yan, N. | Deposit date: | 2022-08-20 | Release date: | 2022-12-07 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels. Cell, 185, 2022
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8E5A
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![BU of 8e5a by Molmil](/molmil-images/mine/8e5a) | Human L-type voltage-gated calcium channel Cav1.3 treated with 1.4 mM Sofosbuvir at 3.3 Angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gao, S, Yao, X, Yan, N. | Deposit date: | 2022-08-20 | Release date: | 2022-12-07 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels. Cell, 185, 2022
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2AXK
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![BU of 2axk by Molmil](/molmil-images/mine/2axk) | Solution structure of discrepin, a scorpion venom toxin blocking K+ channels. | Descriptor: | discrepin | Authors: | Prochnicka-Chalufour, A, Corzo, G, Satake, H, Martin-Eauclaire, M.-F, Murgia, A.R, Prestipino, G, D'Suze, G, Possani, L.D, Delepierre, M. | Deposit date: | 2005-09-05 | Release date: | 2006-06-20 | Last modified: | 2019-12-25 | Method: | SOLUTION NMR | Cite: | Solution structure of discrepin, a new K+-channel blocking peptide from the alpha-KTx15 subfamily. Biochemistry, 45, 2006
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6O7C
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![BU of 6o7c by Molmil](/molmil-images/mine/6o7c) | |
5EIK
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![BU of 5eik by Molmil](/molmil-images/mine/5eik) | Structure of a Trimeric Intracellular Cation channel from C. elegans in the absence of Ca2+ | Descriptor: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ACETATE ION, DECYL-BETA-D-MALTOPYRANOSIDE, ... | Authors: | Hu, M.H, Yang, H.T, Liu, Z.F. | Deposit date: | 2015-10-30 | Release date: | 2016-10-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Pore architecture of TRIC channels and insights into their gating mechanism. Nature, 538, 2016
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5EGI
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![BU of 5egi by Molmil](/molmil-images/mine/5egi) | Structure of a Trimeric Intracellular Cation channel from C. elegans with bound Ca2+ | Descriptor: | CALCIUM ION, DECYL-BETA-D-MALTOPYRANOSIDE, Uncharacterized protein Y57A10A.10, ... | Authors: | Yang, H.T, Hu, M.H, Liu, Z.F. | Deposit date: | 2015-10-27 | Release date: | 2016-10-05 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Pore architecture of TRIC channels and insights into their gating mechanism. Nature, 538, 2016
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1JLZ
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![BU of 1jlz by Molmil](/molmil-images/mine/1jlz) | Solution Structure of a K+-Channel Blocker from the Scorpion Toxin of Tityus cambridgei | Descriptor: | Tityustoxin alpha-KTx | Authors: | Wang, I, Wu, S.-H, Chang, H.-K, Shieh, R.-C, Yu, H.-M, Chen, C. | Deposit date: | 2001-07-17 | Release date: | 2002-02-06 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution structure of a K(+)-channel blocker from the scorpion Tityus cambridgei. Protein Sci., 11, 2002
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3AT8
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![BU of 3at8 by Molmil](/molmil-images/mine/3at8) | |
3ATD
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![BU of 3atd by Molmil](/molmil-images/mine/3atd) | |
3ATA
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![BU of 3ata by Molmil](/molmil-images/mine/3ata) | |
3ATE
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![BU of 3ate by Molmil](/molmil-images/mine/3ate) | |
3KXD
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![BU of 3kxd by Molmil](/molmil-images/mine/3kxd) | |
3AT9
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![BU of 3at9 by Molmil](/molmil-images/mine/3at9) | |
3ATB
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3ATF
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![BU of 3atf by Molmil](/molmil-images/mine/3atf) | |
1U4E
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![BU of 1u4e by Molmil](/molmil-images/mine/1u4e) | Crystal Structure of Cytoplasmic Domains of GIRK1 channel | Descriptor: | G protein-activated inward rectifier potassium channel 1 | Authors: | Pegan, S, Arrabit, C, Zhou, W, Kwiatkowski, W, Slesinger, P.A, Choe, S. | Deposit date: | 2004-07-24 | Release date: | 2005-03-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification Nat.Neurosci., 8, 2005
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7O4H
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![BU of 7o4h by Molmil](/molmil-images/mine/7o4h) | |
4NVP
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![BU of 4nvp by Molmil](/molmil-images/mine/4nvp) | Structure of the cyclic nucleotide-binding domain of HCN4 channel complexed with 7-CH-cAMP | Descriptor: | (2S,4aR,6R,7R,7aS)-6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Authors: | Alfieri, A, Moroni, A. | Deposit date: | 2013-12-05 | Release date: | 2014-03-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Cyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels. Acs Chem.Biol., 9, 2014
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