7U1Q
 
 | | Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with SUR1-in conformation | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Shyng, S.L, Sung, M.W, Driggers, C.M. | | Deposit date: | 2022-02-21 | | Release date: | 2022-08-31 | | Last modified: | 2022-09-14 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
J.Mol.Biol., 434, 2022
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7UQR
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7V5C
 | | Cryo-EM structure of the mouse ABCB9 (ADP.BeF3-bound) | | Descriptor: | ABC-type oligopeptide transporter ABCB9, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | | Authors: | Park, J.G, Kim, S, Jang, E, Choi, S.H, Han, H, Kim, J.W, Ju, S, Min, D.S, Jin, M.S. | | Deposit date: | 2021-08-17 | | Release date: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase.
Nat Commun, 13, 2022
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7V5D
 | | Cryo-EM structure of the mouse ABCB9 (PG-bound) | | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, ABC-type oligopeptide transporter ABCB9 | | Authors: | Park, J.G, Kim, S, Jang, E, Choi, S.H, Han, H, Ju, S, Kim, J.W, Min, D.S, Jin, M.S. | | Deposit date: | 2021-08-17 | | Release date: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase.
Nat Commun, 13, 2022
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7VGF
 | | cryo-EM structure of AMP-PNP bound human ABCB7 | | Descriptor: | Iron-sulfur clusters transporter ABCB7, mitochondrial, MAGNESIUM ION, ... | | Authors: | Yan, Q, Yang, X, Shen, Y. | | Deposit date: | 2021-09-16 | | Release date: | 2022-02-16 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structure of AMP-PNP-bound human mitochondrial ATP-binding cassette transporter ABCB7.
J.Struct.Biol., 214, 2022
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7W02
 | | Cryo-EM structure of ATP-bound ABCA3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Xie, T, Zhang, Z.K, Yue, J, Gong, X. | | Deposit date: | 2021-11-17 | | Release date: | 2022-04-20 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structures of the human surfactant lipid transporter ABCA3.
Sci Adv, 8, 2022
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7W01
 | | Cryo-EM structure of nucleotide-free ABCA3 | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Xie, T, Zhang, Z.K, Yue, J, Gong, X. | | Deposit date: | 2021-11-17 | | Release date: | 2022-04-27 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structures of the human surfactant lipid transporter ABCA3.
Sci Adv, 8, 2022
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7VLS
 | | Structure of SUR2B in complex with MgATP/ADP and P1075 | | Descriptor: | 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Chen, L, Ding, D. | | Deposit date: | 2021-10-05 | | Release date: | 2022-05-18 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural identification of vasodilator binding sites on the SUR2 subunit.
Nat Commun, 13, 2022
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7VLT
 | | Structure of SUR2B in complex with Mg-ATP/ADP and levcromakalim | | Descriptor: | (3S,4R)-2,2-dimethyl-3-oxidanyl-4-(2-oxidanylidenepyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Chen, L, Ding, D. | | Deposit date: | 2021-10-05 | | Release date: | 2022-05-18 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural identification of vasodilator binding sites on the SUR2 subunit.
Nat Commun, 13, 2022
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7VZB
 | | Cryo-EM structure of C22:0-CoA bound human very long-chain fatty acid ABC transporter ABCD1 | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Peroxisomal Membrane Protein related,ATP-binding cassette sub-family D member 1, S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] docosanethioate | | Authors: | Chen, Z.P, Xu, D, Wang, L, Mao, Y.X, Yang, L, Cheng, M.T, Hou, W.T, Chen, Y.X, Zhou, C.Z. | | Deposit date: | 2021-11-15 | | Release date: | 2022-05-18 | | Last modified: | 2022-06-22 | | Method: | ELECTRON MICROSCOPY (3.59 Å) | | Cite: | Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1.
Nat Commun, 13, 2022
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7VX8
 | | Cryo-EM structure of ATP-bound human very long-chain fatty acid ABC transporter ABCD1 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Peroxisomal Membrane Protein related,ATP-binding cassette sub-family D member 1 | | Authors: | Chen, Z.P, Xu, D, Wang, L, Mao, Y.X, Yang, L, Cheng, M.T, Hou, W.T, Chen, Y.X, Zhou, C.Z. | | Deposit date: | 2021-11-12 | | Release date: | 2022-05-18 | | Last modified: | 2022-06-22 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1.
Nat Commun, 13, 2022
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7VLU
 | | Structure of SUR2A in complex with Mg-ATP/ADP and P1075 | | Descriptor: | 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Chen, L, Ding, D. | | Deposit date: | 2021-10-05 | | Release date: | 2022-05-18 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural identification of vasodilator binding sites on the SUR2 subunit.
Nat Commun, 13, 2022
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7VWC
 | | Cryo-EM structure of human very long-chain fatty acid ABC transporter ABCD1 | | Descriptor: | Peroxisomal Membrane Protein related,ATP-binding cassette sub-family D member 1, [(2R)-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-oxidanyl-propyl] octadecanoate | | Authors: | Chen, Z.P, Xu, D, Wang, L, Mao, Y.X, Yang, L, Cheng, M.T, Hou, W.T, Chen, Y.X, Zhou, C.Z. | | Deposit date: | 2021-11-10 | | Release date: | 2022-05-18 | | Last modified: | 2022-06-22 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1.
Nat Commun, 13, 2022
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7VLR
 | | Structure of SUR2B in complex with Mg-ATP/ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Chen, L, Ding, D. | | Deposit date: | 2021-10-05 | | Release date: | 2022-05-18 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural identification of vasodilator binding sites on the SUR2 subunit.
Nat Commun, 13, 2022
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7V8M
 | | LolCDE-apo in nanodiscs | | Descriptor: | Lipoprotein-releasing system ATP-binding protein LolD, Lipoprotein-releasing system transmembrane protein LolC, Lipoprotein-releasing system transmembrane protein LolE | | Authors: | Luo, Q.S, Bei, W.W, Shi, H.G, Zhang, X.Z, Huang, Y.H. | | Deposit date: | 2021-08-23 | | Release date: | 2022-08-31 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Cryo-EM structures of LolCDE reveal the molecular mechanism of bacterial lipoprotein sorting in Escherichia coli.
Plos Biol., 20, 2022
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7V8I
 | | LolCD(E171Q)E with bound AMPPNP in nanodiscs | | Descriptor: | Lipoprotein-releasing system ATP-binding protein LolD, Lipoprotein-releasing system transmembrane protein LolC, Lipoprotein-releasing system transmembrane protein LolE, ... | | Authors: | Bei, W.W, Luo, Q.S, Shi, H.G, Zhang, X.Z, Huang, Y.H. | | Deposit date: | 2021-08-23 | | Release date: | 2022-08-31 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structures of LolCDE reveal the molecular mechanism of bacterial lipoprotein sorting in Escherichia coli.
Plos Biol., 20, 2022
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7VR5
 | | Crystal structure of CmABCB1 W114Y/W161Y/W363Y/W364Y/M391W (4WY/M391W) mutant | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DECYL-BETA-D-MALTOPYRANOSIDE, Probable ATP-dependent transporter ycf16 | | Authors: | Inoue, Y, Ogawa, H, Kato, H. | | Deposit date: | 2021-10-21 | | Release date: | 2022-09-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure-based alteration of tryptophan residues of the multidrug transporter CmABCB1 to assess substrate binding using fluorescence spectroscopy.
Protein Sci., 31, 2022
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7V8L
 | | LolCDE with bound RcsF in nanodiscs | | Descriptor: | (2R)-3-{[(2S)-3-HYDROXY-2-(PALMITOYLAMINO)PROPYL]THIO}PROPANE-1,2-DIYL DIHEXADECANOATE, Lipoprotein-releasing system ATP-binding protein LolD, Lipoprotein-releasing system transmembrane protein LolC, ... | | Authors: | Bei, W.W, Luo, Q.S, Shi, H.G, Zhang, X.Z, Huang, Y.H. | | Deposit date: | 2021-08-23 | | Release date: | 2022-09-21 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Cryo-EM structures of LolCDE reveal the molecular mechanism of bacterial lipoprotein sorting in Escherichia coli.
Plos Biol., 20, 2022
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7VFI
 | | Cryo-EM structure of the mouse TAPL (9mer-peptide bound) | | Descriptor: | ABC-type oligopeptide transporter ABCB9, ARG-ARG-TYR-GLN-LYS-SER-THR-GLU-LEU, CHOLESTEROL HEMISUCCINATE | | Authors: | Park, J.G, Kim, S, Jang, E, Choi, S.H, Han, H, Kim, J.W, Ju, S, Min, D.S, Jin, M.S. | | Deposit date: | 2021-09-13 | | Release date: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (3.98 Å) | | Cite: | The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase.
Nat Commun, 13, 2022
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7VFP
 | | Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with heme and single ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, ... | | Authors: | Li, J, Zheng, W, Gu, M, Zhang, K, Zhu, J.P. | | Deposit date: | 2021-09-13 | | Release date: | 2022-11-09 | | Method: | ELECTRON MICROSCOPY (4.03 Å) | | Cite: | Structures of the CcmABCD heme release complex at multiple states.
Nat Commun, 13, 2022
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7VFJ
 | | Cytochrome c-type biogenesis protein CcmABCD | | Descriptor: | Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, Heme exporter protein C, ... | | Authors: | Zhu, J.P, Zhang, K, Li, J, Zheng, W, Gu, M. | | Deposit date: | 2021-09-13 | | Release date: | 2022-11-09 | | Method: | ELECTRON MICROSCOPY (3.98 Å) | | Cite: | Structures of the CcmABCD heme release complex at multiple states.
Nat Commun, 13, 2022
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7VR1
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7W4O
 | | The structure of KATP H175K mutant in pre-open state | | Descriptor: | 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Chen, L, Wang, M. | | Deposit date: | 2021-11-28 | | Release date: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides.
Nat Commun, 13, 2022
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7W4P
 | | The structure of KATP H175K mutant in closed state | | Descriptor: | 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Chen, L, Wang, M. | | Deposit date: | 2021-11-28 | | Release date: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides.
Nat Commun, 13, 2022
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7W79
 | | Heme exporter HrtBA in complex with Mn-AMPPNP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, Putative ABC transport system integral membrane protein, ... | | Authors: | Hisano, T, Nakamura, H, Rahman, M.M, Tosha, T, Shirouzu, M, Shiro, Y. | | Deposit date: | 2021-12-04 | | Release date: | 2022-06-22 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural basis for heme detoxification by an ATP-binding cassette-type efflux pump in gram-positive pathogenic bacteria.
Proc.Natl.Acad.Sci.USA, 119, 2022
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