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2W8C	Plastocyanin variant with N-terminal Methionine - closed structure Descriptor: COPPER (II) ION, PLASTOCYANIN, ZINC ION Authors: Crowley, P.B, Matias, P.M, Khan, A.R. Deposit date: 2009-01-15 Release date: 2009-10-27 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Metal-Mediated Self-Assembly of a Beta-Sandwich Protein. Chemistry, 15, 2009
4DST	Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity Descriptor: 1,2-ETHANEDIOL, 2-(4,6-dichloro-2-methyl-1H-indol-3-yl)ethanamine, ACETATE ION, ... Authors: Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. Deposit date: 2012-02-19 Release date: 2012-04-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109, 2012
1NWH	Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae as a Tetrahedral Hemithioacetal Reaction Intermediate at 2.0 A Descriptor: Aspartate-semialdehyde dehydrogenase Authors: Blanco, J, Moore, R.A, Viola, R.E. Deposit date: 2003-02-06 Release date: 2003-11-04 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Capture of an Intermediate in the Catalytic Cycle of L-Aspartate-beta-Semialdehyde Dehydrogenase Proc.Natl.Acad.Sci.USA, 100, 2003
4DSO	Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, BENZAMIDINE, GLYCEROL, ... Authors: Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. Deposit date: 2012-02-19 Release date: 2012-04-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109, 2012
4DSU	Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity Descriptor: BENZIMIDAZOLE, GTPase KRas, isoform 2B, ... Authors: Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. Deposit date: 2012-02-19 Release date: 2012-04-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109, 2012
1A5Y	PROTEIN TYROSINE PHOSPHATASE 1B CYSTEINYL-PHOSPHATE INTERMEDIATE Descriptor: PROTEIN TYROSINE PHOSPHATASE 1B Authors: Pannifer, A.D.P, Flint, A.J, Tonks, N.K, Barford, D. Deposit date: 1998-02-19 Release date: 1998-06-17 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography. J.Biol.Chem., 273, 1998
2KGD	NMR Solution Structures of 3-oxo-butyl-ACP, an intermediate mimic from the actinorhodin polyketide synthase in Streptomyces coelicolor Descriptor: Actinorhodin polyketide synthase acyl carrier protein, N~3~-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-{2-[(3-oxobutyl)sulfanyl]ethyl}-beta-alaninamide Authors: Crump, M.P, Evans, S.E, Williams, C. Deposit date: 2009-03-08 Release date: 2009-04-14 Last modified: 2021-10-20 Method: SOLUTION NMR Cite: Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2). J.Mol.Biol., 389, 2009
1TBE	STRUCTURE OF TETRAUBIQUITIN SHOWS HOW MULTIUBIQUITIN CHAINS CAN BE FORMED Descriptor: TETRAUBIQUITIN Authors: Cook, W.J, Jeffrey, L.C, Kasperek, E, Pickart, C.M. Deposit date: 1993-10-14 Release date: 1994-01-31 Last modified: 2019-08-14 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure of tetraubiquitin shows how multiubiquitin chains can be formed. J.Mol.Biol., 236, 1994
2KGC	NMR Solution Structures of octanoyl ACP (a non-natural intermediate) from the actinorhodin polyketide synthase in Streptomyces coelicolor Descriptor: Actinorhodin polyketide synthase acyl carrier protein, S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioate Authors: Crump, M.P, Evans, S.E, Williams, C. Deposit date: 2009-03-08 Release date: 2009-04-14 Last modified: 2021-10-20 Method: SOLUTION NMR Cite: Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2). J.Mol.Biol., 389, 2009
7TYS	Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with Kir6.2-CTD in the up conformation Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Shyng, S.L, Sung, M.W, Driggers, C.M. Deposit date: 2022-02-14 Release date: 2022-08-31 Last modified: 2022-09-14 Method: ELECTRON MICROSCOPY (3.41 Å) Cite: Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
7U1E	CryoEM structure of the pancreatic ATP-sensitive potassium channel bound to ATP with Kir6.2-CTD in the down conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... Authors: Shyng, S.L, Sung, M.W, Driggers, C.M. Deposit date: 2022-02-21 Release date: 2022-08-31 Last modified: 2022-09-14 Method: ELECTRON MICROSCOPY (4.52 Å) Cite: Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
7TYT	Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with Kir6.2-CTD in the down conformation Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Shyng, S.L, Sung, M.W, Driggers, C.M. Deposit date: 2022-02-14 Release date: 2022-08-31 Last modified: 2022-09-14 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
7U1S	Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with SUR1-out conformation Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Shyng, S.L, Sung, M.W, Driggers, C.M. Deposit date: 2022-02-22 Release date: 2022-08-31 Last modified: 2022-09-14 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
7U1Q	Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with SUR1-in conformation Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Shyng, S.L, Sung, M.W, Driggers, C.M. Deposit date: 2022-02-21 Release date: 2022-08-31 Last modified: 2022-09-14 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
7U24	Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and glibenclamide with Kir6.2-CTD in the up conformation Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... Authors: Shyng, S.L, Sung, M.W, Driggers, C.M. Deposit date: 2022-02-23 Release date: 2022-08-31 Last modified: 2022-09-14 Method: ELECTRON MICROSCOPY (3.58 Å) Cite: Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
7U6Y	Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of glibenclamide and ATP with Kir6.2-CTD in the down conformation Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11 Authors: Shyng, S.L, Sung, M.W, Driggers, C.M. Deposit date: 2022-03-06 Release date: 2022-08-31 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (7.4 Å) Cite: Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
7U7M	Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of carbamazepine and ATP with Kir6.2-CTD in the up conformation Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11 Authors: Shyng, S.L, Sung, M.W, Driggers, C.M. Deposit date: 2022-03-07 Release date: 2022-08-31 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (5.2 Å) Cite: Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
7U2X	Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of carbamazepine and ATP with Kir6.2-CTD in the down conformation Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Shyng, S.L, Sung, M.W, Driggers, C.M. Deposit date: 2022-02-25 Release date: 2022-08-31 Last modified: 2022-09-14 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
1Q2S	Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate Descriptor: 5'-R(*AP*GP*CP*AP*CP*GP*GP*CP*UP*(PQ1)P*UP*AP*AP*AP*CP*CP*GP*UP*GP*C)-3', 9-DEAZAGUANINE, Queuine tRNA-ribosyltransferase, ... Authors: Xie, W, Liu, X, Huang, R.H. Deposit date: 2003-07-25 Release date: 2003-09-09 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate Nat.Struct.Biol., 10, 2003
2KG9	NMR Solution Structures of butyryl-ACP (a non-polar, non pathway intermediate) from the actinorhodin polyketide synthase in Streptomyces coelicolor Descriptor: Actinorhodin polyketide synthase acyl carrier protein, THIOBUTYRIC ACID S-{2-[3-(2-HYDROXY-3,3-DIMETHYL-4-PHOSPHONOOXY-BUTYRYLAMINO)-PROPIONYLAMINO]-ETHYL} ESTER Authors: Crump, M.P, Evans, S.E, Williams, C. Deposit date: 2009-03-07 Release date: 2009-04-14 Last modified: 2021-10-20 Method: SOLUTION NMR Cite: Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2). J.Mol.Biol., 389, 2009
7UAA	CryoEM structure of the pancreatic ATP-sensitive potassium channel in the ATP-bound state with Kir6.2-CTD in the up conformation Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11 Authors: Shyng, S.L, Sung, M.W, Driggers, C.M. Deposit date: 2022-03-11 Release date: 2022-08-31 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (5.7 Å) Cite: Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
7UQR	Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the apo form with Kir6.2-CTD in the down conformation Descriptor: ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11 Authors: Shyng, S.L, Sung, M.W, Driggers, C.M. Deposit date: 2022-04-20 Release date: 2022-08-31 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (4.55 Å) Cite: Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
4DSN	Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity Descriptor: 1,2-ETHANEDIOL, GTPase KRas, isoform 2B, ... Authors: Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. Deposit date: 2012-02-19 Release date: 2012-04-25 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109, 2012
2KGA	NMR Solution Structures of hexanoyl ACP (a non natural intermediate) from the actinorhodin polyketide synthase in Streptomyces coelicolor Descriptor: Actinorhodin polyketide synthase acyl carrier protein, S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] hexanethioate Authors: Crump, M.P, Evans, S.E, Williams, C. Deposit date: 2009-03-07 Release date: 2009-04-14 Last modified: 2021-10-20 Method: SOLUTION NMR Cite: Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2). J.Mol.Biol., 389, 2009
1NQ9	Crystal Structure of Antithrombin in the Pentasaccharide-Bound Intermediate State Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, ... Authors: Huntington, J.A, Johnson, D.J.D. Deposit date: 2003-01-21 Release date: 2003-09-30 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal Structure of Antithrombin in a Heparin-Bound Intermediate State Biochemistry, 42, 2003

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