PDB: 68717 resultsInfo pagesStatus searchChemie searchBIRD

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8V63	R207A mutant of human Slo1 in presence of EDTA - activated VSD Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL, Calcium-activated potassium channel subunit alpha-1, ... Authors: Pal, K, Kallure, G.S, Chowdhury, S. Deposit date: 2023-12-01 Release date: 2024-12-11 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (2.72 Å) Cite: R207A mutant of human Slo1 in presence of EDTA - activated VSD To Be Published
2QL1	Structural Characterization of a Mutated, ADCC-Enhanced Human Fc Fragment Descriptor: IGHM protein, ZINC ION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose Authors: Oganesyan, V, Wu, H, Dall'Acqua, W.F. Deposit date: 2007-07-12 Release date: 2008-04-01 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.534 Å) Cite: Structural characterization of a mutated, ADCC-enhanced human Fc fragment Mol.Immunol., 45, 2008
2QWL	Crystal structure of bovine hsc70 (1-394aa)in the ADP state Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock cognate 71 kDa protein, ... Authors: Jiang, J, Maes, E.G, Wang, L, Taylor, A.B, Hinck, A.P, Lafer, E.M, Sousa, R. Deposit date: 2007-08-10 Release date: 2007-12-18 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural basis of J cochaperone binding and regulation of Hsp70. Mol.Cell, 28, 2007
6NKV	Ternary complex crystal structure of DNA polymerase Beta with "hot-spot sequence" with beta-gamma CHF analogue of dGTP Descriptor: 2'-DEOXY-5'-O-[(R)-{[(R)-[(R)-FLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]GUANOSINE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... Authors: Batra, V.K, Wilson, S.H. Deposit date: 2019-01-07 Release date: 2020-01-08 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry, 59, 2020
2R23	Crystal structure of S25-2 Fab in complex with Kdo analogues Descriptor: D-glycero-alpha-D-talo-oct-2-ulopyranosonic acid-(2-4)-prop-2-en-1-yl 3-deoxy-alpha-D-manno-oct-2-ulopyranosidonic acid, Fab, antibody fragment (IgG1k), ... Authors: Brooks, C.L, Evans, S.V. Deposit date: 2007-08-24 Release date: 2008-12-30 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Exploration of specificity in germline monoclonal antibody recognition of a range of natural and synthetic epitopes. J.Mol.Biol., 377, 2008
6NVA	Crystal structure of Escherichia coli dihydrodipicolinate synthase and propionate covalently bound to K161. Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, GLYCEROL, SODIUM ION Authors: Thomas, L.M, Chooback, L. Deposit date: 2019-02-04 Release date: 2019-02-27 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Crystal structure of Escherichia coli dihydrodipicolinate synthase and propionate covalently bound to K161. To Be Published
6V28	Complex of double mutant (T89V,K162T) of E. coli L-asparaginase II with L-Asp Descriptor: GLYCEROL, IMIDAZOLE, L-asparaginase 2 Authors: Lubkowski, J, Wlodawer, A. Deposit date: 2019-11-22 Release date: 2020-05-20 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Mechanism of Catalysis by l-Asparaginase. Biochemistry, 59, 2020
4NY5	X-ray structure of the adduct formed between hen egg white lysozyme and NAMI-A Descriptor: CHLORIDE ION, Lysozyme C, RUTHENIUM ION, ... Authors: Messori, L, Merlino, A. Deposit date: 2013-12-10 Release date: 2014-03-26 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Ruthenium metalation of proteins: the X-ray structure of the complex formed between NAMI-A and hen egg white lysozyme. Dalton Trans, 43, 2014
4NSM	crystal structure of the streptococcal collagen-like protein 2 globular domain from invasive M3-type group A Streptococcus Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Collagen-like protein SclB, SULFATE ION Authors: Berisio, R, Squeglia, F, Lukomski, S, Bachert, B. Deposit date: 2013-11-28 Release date: 2013-12-25 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.6 Å) Cite: The Crystal Structure of the Streptococcal Collagen-like Protein 2 Globular Domain from Invasive M3-type Group A Streptococcus Shows Significant Similarity to Immunomodulatory HIV Protein gp41. J.Biol.Chem., 289, 2014
9BLJ	Crystal structure of a serine protease inhibitor HPI from Hevea brasiliensis Descriptor: Protease inhibitor HPI Authors: Rodriguez-Romero, A, Hernandez-Santoyo, A. Deposit date: 2024-04-30 Release date: 2025-04-30 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Understanding the structure and function of HPI, a rubber tree serine protease inhibitor, and its interaction with subtilisin. Biochem.Biophys.Res.Commun., 763, 2025
6NX9	ECAII(D90T,K162T) MUTANT IN COMPLEX WITH CITRATE AT PH 7 Descriptor: ACETIC ACID, GLYCEROL, IMIDAZOLE, ... Authors: Lubkowski, J, Wlodawer, A. Deposit date: 2019-02-08 Release date: 2019-08-07 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Opportunistic complexes of E. coli L-asparaginases with citrate anions. Sci Rep, 9, 2019
6NN0	Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with 2'-deoxycytidine and fragment degradation product B9D Descriptor: 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, ATP-dependent dethiobiotin synthetase BioD, SULFATE ION, ... Authors: Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B. Deposit date: 2019-01-14 Release date: 2020-01-22 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.343 Å) Cite: Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with 2'-deoxycytidine and B9D To Be Published
9D18	Ca2+ bound open-inactivated hSlo1 + beta2N-beta4 channel in detergent-conformation 2 of inactivating domain Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL, ... Authors: Agarwal, S, Nimigean, C. Deposit date: 2024-08-07 Release date: 2025-03-05 Method: ELECTRON MICROSCOPY (2.88 Å) Cite: Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel. Nat Commun, 16, 2025
1GQB	HUMAN MIR-RECEPTOR, REPEAT 11 Descriptor: BROMIDE ION, CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR Authors: Von Buelow, R, Dauter, M, Dauter, Z, Rajashankar, K.R, Grimme, S, Schmidt, B, Von Figura, K, Uson, I. Deposit date: 2001-11-22 Release date: 2002-12-05 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Locating the Anomalous Scatterer Substructures in Halide and Sulfur Phasing Acta Crystallogr.,Sect.D, 59, 2003
9D19	Ca2+ bound open-inactivated hSlo1 + beta2N-beta4 channel in detergent-conformation 3 of inactivating domain Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL, ... Authors: Agarwal, S, Nimigean, C. Deposit date: 2024-08-07 Release date: 2025-03-05 Method: ELECTRON MICROSCOPY (2.88 Å) Cite: Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel. Nat Commun, 16, 2025
1HLZ	CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB(ALPHA) DNA-BINDING DOMAIN BOUND TO ITS COGNATE RESPONSE ELEMENT Descriptor: 5'-D(*CP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*CP*TP*AP*GP*GP*TP*CP*AP*G)-3', 5'-D(*CP*TP*GP*AP*CP*CP*TP*AP*GP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*G)-3', ORPHAN NUCLEAR RECEPTOR NR1D1, ... Authors: Sierk, M.L, Zhao, Q, Rastinejad, F. Deposit date: 2000-12-04 Release date: 2001-11-16 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: DNA Deformability as a Recognition Feature in the RevErb Response Element Biochemistry, 40, 2001
6OII	Structure of Aedes aegypti OBP22 in the complex with arachidonic acid Descriptor: 1,2-ETHANEDIOL, AAEL005772-PA, ARACHIDONIC ACID, ... Authors: Jones, D.N, Wang, J. Deposit date: 2019-04-09 Release date: 2019-05-08 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail. Sci Rep, 10, 2020
4RYU	Crystal Structure of C2 form of E112A Mutant of Stationary Phase Survival Protein (SurE) from Salmonella typhimurium Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 5'/3'-nucleotidase SurE, GLYCEROL, ... Authors: Mathiharan, Y.K, Murthy, M.R.N. Deposit date: 2014-12-17 Release date: 2015-09-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Insights into stabilizing interactions in the distorted domain-swapped dimer of Salmonella typhimurium survival protein. Acta Crystallogr. D Biol. Crystallogr., 71, 2015
6PTP	Joint X-ray/neutron structure of HIV-1 protease triple mutant (V32I,I47V,V82I) with tetrahedral intermediate mimic KVS-1 Descriptor: HIV-1 Protease, N~2~-[(2R,5S)-5-({(2S,3S)-2-[(N-acetyl-L-threonyl)amino]-3-methylpent-4-enoyl}amino)-2-butyl-4,4-dihydroxynonanoyl]-L-glutaminyl-L-argininamide Authors: Kovalevsky, A, Das, A. Deposit date: 2019-07-16 Release date: 2020-06-10 Last modified: 2023-10-25 Method: NEUTRON DIFFRACTION (1.85 Å), X-RAY DIFFRACTION Cite: Visualizing Tetrahedral Oxyanion Bound in HIV-1 Protease Using Neutrons: Implications for the Catalytic Mechanism and Drug Design. Acs Omega, 5, 2020
4O03	Crystal structure of Ca2+ bound prothrombin deletion mutant residues 146-167 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Prothrombin Authors: Pozzi, N, Chen, Z, Shropshire, D.B, Pelc, L.A, Di Cera, E. Deposit date: 2013-12-13 Release date: 2014-05-21 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (3.38 Å) Cite: The linker connecting the two kringles plays a key role in prothrombin activation. Proc.Natl.Acad.Sci.USA, 111, 2014
4RR6	N-terminal editing domain of threonyl-tRNA synthetase from Aeropyrum pernix with L-Ser3AA (snapshot 1) Descriptor: Probable threonine--tRNA ligase 2, SERINE-3'-AMINOADENOSINE Authors: Ahmad, S, Muthukumar, S, Yerabham, A.S.K, Kamarthapu, V, Sankaranarayanan, R. Deposit date: 2014-11-06 Release date: 2015-07-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Specificity and catalysis hardwired at the RNA-protein interface in a translational proofreading enzyme. Nat Commun, 6, 2015
2QTF	Crystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus Descriptor: ACETATE ION, CADMIUM ION, GTP-binding protein, ... Authors: Wu, H, Sun, L, Brouns, S.J, Fu, S, Rao, Z, Van der Oost, J. Deposit date: 2007-08-02 Release date: 2008-08-19 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus. To be Published
6NXZ	Crystal structure of trimethoprim-resistant type II dihydrofolate reductase in complex with a bisbenzimidazole inhibitor Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-[4-[(2~{R})-4-[4-(6-carboxy-1~{H}-benzimidazol-2-yl)phenoxy]-2-oxidanyl-butoxy]phenyl]-1~{H}-benzimidazole-5-carboxylic acid, Dihydrofolate reductase type 2, ... Authors: Yachnin, B.J, Berghuis, A.M. Deposit date: 2019-02-10 Release date: 2019-05-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues. Acs Omega, 4, 2019
2QKH	Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP Descriptor: Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, D(-)-TARTARIC ACID, Glucose-dependent insulinotropic polypeptide, ... Authors: Parthier, C, Kleinschmidt, M, Neumann, P, Rudolph, R, Manhart, S, Schlenzig, D, Fanghanel, J, Rahfeld, J.-U, Demuth, H.-U, Stubbs, M.T. Deposit date: 2007-07-11 Release date: 2007-08-14 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor Proc.Natl.Acad.Sci.Usa, 104, 2007
2QLQ	Crystal structure of SRC kinase domain with covalent inhibitor RL3 Descriptor: (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide, Proto-oncogene tyrosine-protein kinase Src Authors: Michalczyk, A, Rode, H.B, Gruetter, C, Rauh, D. Deposit date: 2007-07-13 Release date: 2008-03-11 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. Bioorg.Med.Chem., 16, 2008

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