2QKH

Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP

Summary for 2QKH

• Entry DOI: 10.2210/pdb2qkh/pdb
• Related PRD ID: PRD_900086
• Descriptor: Glucose-dependent insulinotropic polypeptide, Glucose-dependent insulinotropic polypeptide receptor, Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: gpcr, incretin, hormone-gpcr complex, extracellular domain, ligand binding domain, ecd, glugacon receptor family, hormone recognition fold, diabetes, helix formation, cleavage on pair of basic residues, polymorphism, alternative splicing, g-protein coupled receptor, glycoprotein, membrane, transducer, transmembrane, signaling protein-hormone complex, signaling protein/hormone
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 21782.85

Authors

Parthier, C.,Kleinschmidt, M.,Neumann, P.,Rudolph, R.,Manhart, S.,Schlenzig, D.,Fanghanel, J.,Rahfeld, J.-U.,Demuth, H.-U.,Stubbs, M.T. (deposition date: 2007-07-11, release date: 2007-08-14, Last modification date: 2020-07-29)

• Primary citation: Parthier, C.,Kleinschmidt, M.,Neumann, P.,Rudolph, R.,Manhart, S.,Schlenzig, D.,Fanghanel, J.,Rahfeld, J.-U.,Demuth, H.-U.,Stubbs, M.T.; Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor; Proc.Natl.Acad.Sci.Usa, 104:13942-13947, 2007; PubMed: 17715056; DOI: 10.1073/pnas.0706404104

Experimental method

X-RAY DIFFRACTION (1.9 Å)