2QKH

Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Glucose-dependent insulinotropic polypeptide	polymer	42	4990.6	1	UniProt (P09681) Pfam (PF00123)		Gastric inhibitory polypeptide, GIP
2	B (A)	Glucose-dependent insulinotropic polypeptide receptor	polymer	135	15391.0	1	UniProt (P48546) Pfam (PF02793)	Homo sapiens (human)	Gastric inhibitory polypeptide receptor, GIP-R
3	C (C)	Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose	branched		1251.2	1	In PDB BIRD (PRD_900086) GlyTouCan (G04274SM)		methyl-beta-cyclodextrin
4	D (A)	D(-)-TARTARIC ACID	non-polymer		150.1	1	Chemie (TAR)
5	E, F (B, A)	water	water		18.0	133	Chemie (HOH)

Sequence modifications

A: 24 - 138 (UniProt: P48546)

PDB	External Database	Details
Gly 4	-	expression tag
Ser 5	-	expression tag
Ser 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
His 12	-	expression tag
Ser 13	-	expression tag
Ser 14	-	expression tag
Gly 15	-	expression tag
Leu 16	-	expression tag
Val 17	-	expression tag
Pro 18	-	expression tag
Arg 19	-	expression tag
Gly 20	-	expression tag
Ser 21	-	expression tag
His 22	-	expression tag
Met 23	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	20381.6
Branched	Number of molecules	1
	Total formula weight	1251.2
Non-Polymers*	Number of molecules	1
	Total formula weight	150.1
All*	Total formula weight	21782.9

*Water molecules are not included.